HitPredict

Interactor 1: DC8L2 (P0C7V8)
DDB1- and CUL4-associated factor 8-like protein 2 (WD repeat-containing protein 42C)
Gene: DCAF8L2

Interactor 2: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 35487060
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CPSF_A~WD40, MMS1_N~WD40
Common GO terms	GO:0005737 - cytoplasm GO:0080008 - Cul4-RING E3 ubiquitin ligase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 631 Hs			1 1140
+	Hs
		1082225 DCAF8_HUMAN (1-631): 8.69e-125: 383: 64.56		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Mm
		1112284 DCAF8_MOUSE (2-631): 4.76e-122: 375: 63.23		DDB1_MOUSE (1-1140): 0: 1422: 99.65
+	Mm
		1112266 WDR82_MOUSE (213-543): 1.04e-63: 214: 20.72		DDB1_MOUSE (1-1140): 0: 1422: 99.65
+	Hs
		1082263 WDR5B_HUMAN (358-627): 6.66e-50: 178: 12.13		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Hs
		1082281 WDTC1_HUMAN (453-631): 8.39e-38: 151: 31.67		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Mm
		1112265 WDTC1_MOUSE (453-631): 4.21e-37: 149: 31.67		DDB1_MOUSE (1-1140): 0: 1422: 99.65
+	Hs
		245605 TBL1X_HUMAN (400-630): 2.8e-32: 133: 12.92		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Hs
		1082217 DCAF6_HUMAN (450-610): 1.2e-30: 129: 33.54		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Mm
		1112305 DCAF6_MOUSE (450-610): 3.02e-31: 131: 33.54		DDB1_MOUSE (1-1140): 0: 1422: 99.65
+	Zm
		37968 B4FRU9_MAIZE (183-624): 5.51e-90: 288: 30.63		A0A1D6ME60_MAIZE (3-1140): 0: 1244: 52.57
+	At
		1340744 Q9M1E5_ARATH (183-631): 2.16e-85: 276: 29.67		DDB1A_ARATH (2-1140): 0: 1255: 52.09
+	At
		221833 Q9M1E5_ARATH (183-631): 2.16e-85: 276: 29.67		DDB1B_ARATH (3-1140): 0: 1248: 50.92
+	Hs
		903254 WDR5_HUMAN (459-581): 1.29e-17: 86.4: 19.36		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Hs
		1082327 SNR40_HUMAN (115-295): 7.24e-16: 81.5: 14.37		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Hs
		1016284 TBL3_HUMAN (95-255): 1.16e-14: 79.6: 9.70		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Hs
		1073094 FBXW7_HUMAN (118-390): 2.4e-44: 170: 15.94		SF3B3_HUMAN (3-1126): 0: 1102: 21.33
+	Hs
		1073168 NLE1_HUMAN (503-627): 5.85e-18: 89: 16.41		SF3B3_HUMAN (3-1126): 0: 1102: 21.33
+	Sp
		143270 IQW1_SCHPO (460-595): 1.03e-41: 163: 34.04		DDB1_SCHPO (5-1140): 0: 835: 24.39
+	Hs
		197009 PRP4_HUMAN (316-618): 4.25e-45: 169: 10.58		CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87
+	Hs
		1014208 NLE1_HUMAN (503-627): 5.85e-18: 89: 16.41		CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87