HitPredict

Interactor 1: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Interactor 2: RN166 (Q96A37)
E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING finger protein 166) (RING-type E3 ubiquitin transferase RNF166)
Gene: RNF166

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ubiquitin~zf-RING_UBOX
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 229 Hs			1 237
+	Mm
		476671 UBB_MOUSE (1-228): 1.3e-95: 283: 100.00		RO52_MOUSE (15-165): 5.11e-31: 120: 18.54
+	Hs
		475253 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		TRAF6_HUMAN (8-235): 8.66e-29: 114: 17.83
+	Hs
		475011 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		TRAF2_HUMAN (15-186): 9.47e-27: 109: 20.65
+	Hs
		475177 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		TRIM5_HUMAN (21-166): 6.19e-25: 103: 20.53
+	Hs
		476160 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		RN166_HUMAN (1-237): 6.66e-64: 200: 100.00
+	Mm
		476977 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		RN138_MOUSE (21-237): 2.08e-44: 150: 31.25
+	Hs
		476111 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		RN138_HUMAN (21-237): 4.61e-45: 152: 30.83
+	Rn
		88507 UBC_RAT (1-181): 2.6e-61: 206: 96.13		D3Z9G0_RAT (15-215): 9.63e-32: 123: 20.29
+	Mm
		476831 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		RO52_MOUSE (15-165): 5.11e-31: 120: 18.54
+	Hs
		476188 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		RN125_HUMAN (6-236): 1.1e-41: 143: 30.67
+	Mm
		476826 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		TRAF4_MOUSE (17-212): 1.03e-28: 114: 18.50
+	Hs
		475680 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		TRI26_HUMAN (19-174): 1.05e-34: 131: 18.24
+	Rn
		78208 UBC_RAT (1-181): 2.6e-61: 206: 96.13		B5DFH7_RAT (15-186): 1.64e-25: 105: 19.57
+	Hs
		129527 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		TRAF5_HUMAN (12-237): 8.71e-31: 120: 21.21
+	Hs
		475328 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		RO52_HUMAN (19-166): 8.73e-31: 120: 20.95
+	Hs
		475309 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		RAG1_HUMAN (30-149): 1.21e-28: 115: 28.23
+	Hs
		476299 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		TRAF4_HUMAN (17-212): 3.54e-28: 112: 18.50
+	Hs
		475684 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		TRAF2_HUMAN (15-186): 9.47e-27: 109: 20.65
+	Hs
		476330 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		TRIM5_HUMAN (21-166): 6.19e-25: 103: 20.53
+	Hs
		475842 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		RN151_HUMAN (24-172): 3.71e-22: 93: 24.05