Protein: DDX42
ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125)

Gene: DDX42
Organism: Homo sapiens
Interactions: 198
UniProt ID: Q86XP3

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1294104

SPF45
Splicing factor 45

2

13

High-throughput

0.776

High

207579

DHX15
ATP-dependent RNA helicase DHX15

2

9

High-throughput

0.767

High

1294111

DDX23
Probable ATP-dependent RNA helicase DDX23

2

17

High-throughput

0.754

High

316298

RECQ5
ATP-dependent DNA helicase Q5

1

17

High-throughput

0.698

High

1005470

RBM6
RNA-binding protein 6

1

13

High-throughput

0.691

High

1148518

SF3B4
Splicing factor 3B subunit 4

3

9

High-throughput

0.664

High

775181

FUS
RNA-binding protein FUS

3

17

High-throughput

0.656

High

1148614

SF3A2
Splicing factor 3A subunit 2

3

4

Small-scale

0.656

High

848791

MAGAA
Melanoma-associated antigen 10

3

6

High-throughput

0.650

High

480209

RU1C
U1 small nuclear ribonucleoprotein C

2

3

High-throughput

0.625

High

1149119

SF3A1
Splicing factor 3A subunit 1

2

2

High-throughput

0.625

High

285349

EED
Polycomb protein EED

1

18

High-throughput

0.618

High

684299

DDX6
Probable ATP-dependent RNA helicase DDX6

1

15

High-throughput

0.618

High

854884

RECQ1
ATP-dependent DNA helicase Q1

1

15

High-throughput

0.618

High

1088429

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

10

High-throughput

0.618

High

1128049

DHX8
ATP-dependent RNA helicase DHX8

1

8

High-throughput

0.618

High

1132804

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

10

High-throughput

0.618

High

1226996

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.618

High

1250011

WDR82
WD repeat-containing protein 82

1

12

High-throughput

0.618

High

1254489

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.618

High

1294122

DCA13
DDB1- and CUL4-associated factor 13

1

10

High-throughput

0.618

High

1294123

DDX56
Probable ATP-dependent RNA helicase DDX56

1

17

High-throughput

0.618

High

1294130

RUVB2
RuvB-like 2

1

1

High-throughput

0.618

High

1294131

RUVB1
RuvB-like 1

1

1

High-throughput

0.618

High

285985

SF3B1
Splicing factor 3B subunit 1

2

3

Small-scale

0.611

High

542104

TOP1
DNA topoisomerase 1

2

3

High-throughput

0.611

High

1126984

RBM39
RNA-binding protein 39

2

12

High-throughput

0.611

High

1160195

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

2

8

High-throughput

0.611

High

129234

MEN1
Menin

2

3

High-throughput

0.584

High

520181

ANDR
Androgen receptor

2

18

High-throughput

0.584

High

558249

XRCC6
X-ray repair cross-complementing protein 6

2

5

High-throughput

0.584

High

904897

MECP2
Methyl-CpG-binding protein 2

2

11

High-throughput

0.584

High

1271720

MEPCE
7SK snRNA methylphosphate capping enzyme

2

4

High-throughput

0.584

High

1294115

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

2

4

High-throughput

0.584

High

436697

KPCB
Protein kinase C beta type

2

3

High-throughput

0.571

High

531101

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

2

High-throughput

0.571

High

1242415

RHGBA
Rho GTPase-activating protein 11A

2

5

High-throughput

0.571

High

1294086

SH2D3
SH2 domain-containing protein 3C

2

6

High-throughput

0.571

High

163996

NDC80
Kinetochore protein NDC80 homolog

1

1

High-throughput

0.536

High

251615

CCNT1
Cyclin-T1

1

3

High-throughput

0.536

High

298408

DNJC8
DnaJ homolog subfamily C member 8

1

2

High-throughput

0.536

High

324967

HEXI1
Protein HEXIM1

1

4

High-throughput

0.536

High

335872

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

2

High-throughput

0.536

High

424523

PAI2
Plasminogen activator inhibitor 2

1

2

High-throughput

0.536

High

471877

RU2B
U2 small nuclear ribonucleoprotein B''

1

15

High-throughput

0.536

High

478110

SNRPA
U1 small nuclear ribonucleoprotein A

1

11

High-throughput

0.536

High

574356

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

2

High-throughput

0.536

High

659252

SP100
Nuclear autoantigen Sp-100

1

10

High-throughput

0.536

High

685633

U2AF2
Splicing factor U2AF 65 kDa subunit

1

20

High-throughput

0.536

High

973758

RUXE
Small nuclear ribonucleoprotein E

1

1

High-throughput

0.536

High

973968

RUXF
Small nuclear ribonucleoprotein F

1

4

High-throughput

0.536

High

1065282

SSRP1
FACT complex subunit SSRP1

1

9

High-throughput

0.536

High

1105333

SF3B2
Splicing factor 3B subunit 2

1

1

High-throughput

0.536

High

1147941

SF3B3
Splicing factor 3B subunit 3

1

2

High-throughput

0.536

High

1294112

SF3B5
Splicing factor 3B subunit 5

1

1

High-throughput

0.536

High

1294121

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.536

High

1294133

SF3B6
Splicing factor 3B subunit 6

1

12

High-throughput

0.536

High

868366

CDX1
Homeobox protein CDX-1

1

2

High-throughput

0.515

High

788704

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

884157

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

974599

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.513

High

1088698

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.513

High

1212413

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.513

High

1274023

PHF5A
PHD finger-like domain-containing protein 5A

1

0

High-throughput

0.513

High

175724

SR140
U2 snRNP-associated SURP motif-containing protein

1

9

High-throughput

0.508

High

1294129

PRP19
Pre-mRNA-processing factor 19

1

11

High-throughput

0.508

High

422489

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

1028269

MDM2
E3 ubiquitin-protein ligase Mdm2

1

2

Small-scale

0.501

High

339527

ACSL3
Fatty acid CoA ligase Acsl3

1

0

High-throughput

0.493

High

1294125

DJB11
DnaJ homolog subfamily B member 11

1

0

High-throughput

0.493

High

1294094

FBX25
F-box only protein 25

1

0

Small-scale

0.480

High

129760

CBX4
E3 SUMO-protein ligase CBX4

1

3

High-throughput

0.479

High

134790

SAP18
Histone deacetylase complex subunit SAP18

1

4

High-throughput

0.479

High

157574

CTRO
Citron Rho-interacting kinase

1

11

High-throughput

0.479

High

212272

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

1

High-throughput

0.479

High

227603

SPOP
Speckle-type POZ protein

1

3

High-throughput

0.479

High

242184

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.479

High

247372

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

7

High-throughput

0.479

High

247987

NUPR1
Nuclear protein 1

1

5

High-throughput

0.479

High

252256

CCNT2
Cyclin-T2

1

3

High-throughput

0.479

High

260143

BRD4
Bromodomain-containing protein 4

1

10

High-throughput

0.479

High

272297

OBSL1
Obscurin-like protein 1

1

4

High-throughput

0.479

High

280704

PR40A
Pre-mRNA-processing factor 40 homolog A

1

14

High-throughput

0.479

High

318506

TOX4
TOX high mobility group box family member 4

1

10

High-throughput

0.479

High

324305

ARHGF
Rho guanine nucleotide exchange factor 15

1

1

High-throughput

0.479

High

372473

MYC
Myc proto-oncogene protein

1

8

High-throughput

0.479

High

385922

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

10

High-throughput

0.479

High

412206

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.479

High

425560

ISG15
Ubiquitin-like protein ISG15

1

5

High-throughput

0.479

High

437253

K2C8
Keratin, type II cytoskeletal 8

1

3

High-throughput

0.479

High

476744

RSSA
Small ribosomal subunit protein uS2

1

2

High-throughput

0.479

High

565418

ITA4
Integrin alpha-4

1

6

High-throughput

0.479

High

566740

PDIA4
Protein disulfide-isomerase A4

1

1

High-throughput

0.479

High

589078

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

598129

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

1

High-throughput

0.479

High

606894

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.479

High

634856

HXA5
Homeobox protein Hox-A5

1

2

High-throughput

0.479

High

655259

SFPQ
Splicing factor, proline- and glutamine-rich

1

11

High-throughput

0.479

High

675569

TYY1
Transcriptional repressor protein YY1

1

6

High-throughput

0.479

High

695865

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

714240

PML
Protein PML

1

13

High-throughput

0.479

High

768578

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

791505

SYUA
Alpha-synuclein

1

3

High-throughput

0.479

High

799267

BRCA1
Breast cancer type 1 susceptibility protein

1

13

High-throughput

0.479

High

809710

RS19
Small ribosomal subunit protein eS19

1

2

High-throughput

0.479

High

831014

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

877163

KC1D
Casein kinase I isoform delta

1

2

High-throughput

0.479

High

885829

KC1E
Casein kinase I isoform epsilon

1

3

High-throughput

0.479

High

889142

RBM25
RNA-binding protein 25

1

3

High-throughput

0.479

High

897891

CDK9
Cyclin-dependent kinase 9

1

8

High-throughput

0.479

High

935550

MFAP1
Microfibrillar-associated protein 1

1

1

High-throughput

0.479

High

937810

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.479

High

967836

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

5

High-throughput

0.479

High

973227

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

978597

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

979927

H4
Histone H4

1

4

High-throughput

0.479

High

998502

H31
Histone H3.1

1

8

High-throughput

0.479

High

1004787

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

1050470

UBE3A
Ubiquitin-protein ligase E3A

1

7

High-throughput

0.479

High

1058504

CKAP4
Cytoskeleton-associated protein 4

1

7

High-throughput

0.479

High

1067482

EP300
Histone acetyltransferase p300

1

9

High-throughput

0.479

High

1083398

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

2

High-throughput

0.479

High

1086373

AKP13
A-kinase anchor protein 13

1

1

High-throughput

0.479

High

1088901

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

1092459

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

2

High-throughput

0.479

High

1096741

RFA4
Replication protein A 30 kDa subunit

1

7

High-throughput

0.479

High

1097404

CBX3
Chromobox protein homolog 3

1

3

High-throughput

0.479

High

1106996

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.479

High

1109165

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

12

High-throughput

0.479

High

1111085

SNW1
SNW domain-containing protein 1

1

5

High-throughput

0.479

High

1121818

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

2

High-throughput

0.479

High

1124643

SRC8
Src substrate cortactin

1

1

High-throughput

0.479

High

1134974

CUL7
Cullin-7

1

7

High-throughput

0.479

High

1144401

NONO
Non-POU domain-containing octamer-binding protein

1

14

High-throughput

0.479

High

1205068

FA76B
Protein FAM76B

1

1

High-throughput

0.479

High

1213063

RHG21
Rho GTPase-activating protein 21

1

4

High-throughput

0.479

High

1241267

TAF2
Transcription initiation factor TFIID subunit 2

1

1

High-throughput

0.479

High

1251332

DJC14
DnaJ homolog subfamily C member 14

1

1

High-throughput

0.479

High

1276439

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1281548

SLN11
Schlafen family member 11

1

1

High-throughput

0.479

High

1289433

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

1294085

SMC5
Structural maintenance of chromosomes protein 5

1

5

High-throughput

0.479

High

1294087

NGEF
Ephexin-1

1

5

High-throughput

0.479

High

1294088

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

6

High-throughput

0.479

High

1294091

RB15B
Putative RNA-binding protein 15B

1

10

High-throughput

0.479

High

1294093

FA76A
Protein FAM76A

1

1

High-throughput

0.479

High

1294095

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

4

High-throughput

0.479

High

1294097

ATX2L
Ataxin-2-like protein

1

5

High-throughput

0.479

High

1294098

PSPC1
Paraspeckle component 1

1

14

High-throughput

0.479

High

1294099

TOPB1
DNA topoisomerase 2-binding protein 1

1

7

High-throughput

0.479

High

1294100

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

6

High-throughput

0.479

High

1294101

RBP56
TATA-binding protein-associated factor 2N

1

13

High-throughput

0.479

High

1294102

CSN5
COP9 signalosome complex subunit 5

1

10

High-throughput

0.479

High

1294106

CDC5L
Cell division cycle 5-like protein

1

4

High-throughput

0.479

High

1294108

ANM1
Protein arginine N-methyltransferase 1

1

5

High-throughput

0.479

High

1294116

NSRP1
Nuclear speckle splicing regulatory protein 1

1

1

High-throughput

0.479

High

1294118

PKHA4
Pleckstrin homology domain-containing family A member 4

1

15

High-throughput

0.479

High

1294120

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

2

High-throughput

0.479

High

1294126

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1294127

VAV3
Guanine nucleotide exchange factor VAV3

1

5

High-throughput

0.479

High

1294117

TMX1
Thioredoxin-related transmembrane protein 1

1

2

High-throughput

0.470

High

217474

E41L2
Band 4.1-like protein 2

1

0

High-throughput

0.458

High

228308

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.458

High

359684

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.458

High

867801

IF1AX
Eukaryotic translation initiation factor 1A, X-chromosomal

1

0

High-throughput

0.458

High

871968

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

0

High-throughput

0.458

High

954711

SEM1
26S proteasome complex subunit SEM1

1

0

Small-scale

0.458

High

980897

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

992606

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.458

High

1248035

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

0

High-throughput

0.458

High

1277840

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.458

High

1294090

PR38A
Pre-mRNA-splicing factor 38A

1

0

High-throughput

0.458

High

1294092

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.458

High

1294096

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

0

High-throughput

0.458

High

1294105

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

0

High-throughput

0.458

High

1294107

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.458

High

1294110

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.458

High

1294113

NUSAP
Nucleolar and spindle-associated protein 1

1

0

High-throughput

0.458

High

1294119

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1294124

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1294128

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.458

High

1294132

RCL1
RNA 3'-terminal phosphate cyclase-like protein

1

0

High-throughput

0.458

High

1294134

SPIN1
Spindlin-1

1

0

High-throughput

0.458

High

530039

TAU
Microtubule-associated protein tau

1

9

High-throughput

0.445

High

911632

NCBP2
Nuclear cap-binding protein subunit 2

1

15

High-throughput

0.445

High

1150757

SF01
Splicing factor 1

1

9

High-throughput

0.445

High

1209348

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

1234849

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.445

High

1292257

S2611
Sodium-independent sulfate anion transporter

1

2

High-throughput

0.445

High

1294114

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

1142322

PDIA6
Protein disulfide-isomerase A6

1

1

High-throughput

0.437

High

1258053

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

2

Small-scale

0.437

High

1155073

UT2
Urea transporter 2

1

0

High-throughput

0.426

High

1294089

S35G3
Solute carrier family 35 member G3

1

0

High-throughput

0.426

High

619849

VCAM1
Vascular cell adhesion protein 1

1

3

High-throughput

0.407

High

1294103

S41A3
Solute carrier family 41 member 3

1

1

High-throughput

0.407

High

720501

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.249

Low

1294109

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025