HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: R144A (P50876)
E3 ubiquitin-protein ligase RNF144A (EC 2.3.2.31) (RING finger protein 144A) (UbcM4-interacting protein 4) (Ubiquitin-conjugating enzyme 7-interacting protein 4)
Gene: RNF144A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	28943312
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	IBR~ubiquitin
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane GO:0010008 - endosome membrane GO:0016567 - protein ubiquitination
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 292
+	Hs
		475976 UBC_HUMAN (1-685): 0: 846: 100.00		R144B_HUMAN (3-285): 2.41e-87: 264: 54.77
+	Hs
		475939 UBC_HUMAN (1-685): 0: 846: 100.00		RN19B_HUMAN (13-276): 3.98e-73: 240: 25.54
+	Hs
		476630 UBC_HUMAN (1-685): 0: 846: 100.00		ARI1_HUMAN (14-229): 1.58e-64: 213: 27.35
+	Hs
		312458 UBC_HUMAN (1-685): 0: 846: 100.00		ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53
+	Hs
		476496 UBC_HUMAN (1-685): 0: 846: 100.00		AKIB1_HUMAN (20-227): 2.36e-61: 211: 23.85
+	Hs
		476187 UBC_HUMAN (1-685): 0: 846: 100.00		RNF31_HUMAN (19-218): 8.15e-50: 178: 23.04
+	Dm
		477528 UBIQP_DROME (1-610): 0: 752: 99.84		LUBEL_DROME (19-225): 2.33e-55: 194: 22.22
+	Hs
		476460 UBC_HUMAN (1-685): 0: 846: 100.00		RN216_HUMAN (17-219): 3.83e-12: 68.6: 27.54
+	Dm
		1214032 Q9W418_DROME (229-685): 0: 557: 99.78		LUBEL_DROME (19-225): 2.33e-55: 194: 22.22
+	Sc
		477225 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		HEL1_YEAST (11-221): 5.64e-54: 185: 21.56
+	At
		1092233 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		Q9M1E9_ARATH (13-229): 2.64e-51: 175: 22.97
+	Hs
		475069 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		RN19B_HUMAN (13-276): 3.98e-73: 240: 25.54
+	Hs
		475094 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		CUL9_HUMAN (9-223): 4.72e-62: 214: 24.78
+	Hs
		312457 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53
+	Mm
		476959 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RNF31_MOUSE (19-218): 2.3e-49: 177: 23.26
+	Hs
		475133 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		RNF31_HUMAN (19-218): 8.15e-50: 178: 23.04
+	Mm
		476729 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RN216_MOUSE (17-219): 1.81e-12: 69.3: 27.54