Protein: OSTP
Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin)

Gene: OSTP, SPP1
Organism: Homo sapiens
Interactions: 98
UniProt ID: P10451

Gene Ontology (top 5):
GO:0001649 - osteoblast differentiation
GO:0005125 - cytokine activity
GO:0005178 - integrin binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

226685

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

5

1

Small-scale

0.664

High

522249

BAG6
Large proline-rich protein BAG6

3

2

Small-scale

0.654

High

522278

FA20C
Extracellular serine/threonine protein kinase FAM20C

3

1

Small-scale

0.624

High

522298

UBQL4
Ubiquilin-4

2

1

Small-scale

0.613

High

522256

NCS1
Neuronal calcium sensor 1

2

1

High-throughput

0.606

High

223978

GET3
ATPase GET3

2

0

High-throughput

0.580

High

522286

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

2

1

High-throughput

0.553

High

410549

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

0

High-throughput

0.551

High

522244

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

1

Small-scale

0.536

High

522234

PEPD
Xaa-Pro dipeptidase

1

0

High-throughput

0.518

High

522253

CCR8
C-C chemokine receptor type 8

1

0

High-throughput

0.518

High

431670

ITB1
Integrin beta-1

1

1

Small-scale

0.501

High

522238

ITB5
Integrin beta-5

1

1

Small-scale

0.501

High

522251

MAP1B
Microtubule-associated protein 1B

1

3

Small-scale

0.481

High

447964

ITAV
Integrin alpha-V

1

0

Small-scale

0.480

High

522241

IBP5
Insulin-like growth factor-binding protein 5

1

0

Small-scale

0.480

High

522248

CASP3
Caspase-3

1

1

Small-scale

0.471

High

522265

CASP8
Caspase-8

1

1

Small-scale

0.471

High

333285

SNAPN
SNARE-associated protein Snapin

1

0

Small-scale

0.460

High

345293

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

Small-scale

0.460

High

359907

NB5R3
NADH-cytochrome b5 reductase 3

1

0

Small-scale

0.460

High

387215

APOA1
Apolipoprotein A-I

1

0

High-throughput

0.460

High

391549

FRIH
Ferritin heavy chain

1

0

Small-scale

0.460

High

457188

TBB5
Tubulin beta chain

1

0

Small-scale

0.460

High

522235

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.460

High

522237

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

0

Small-scale

0.460

High

522239

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

0

Small-scale

0.460

High

522242

DNJB1
DnaJ homolog subfamily B member 1

1

0

Small-scale

0.460

High

522245

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

Small-scale

0.460

High

522250

RL5
Large ribosomal subunit protein uL18

1

0

Small-scale

0.460

High

522257

RS13
Small ribosomal subunit protein uS15

1

0

Small-scale

0.460

High

522258

EF1A1
Elongation factor 1-alpha 1

1

0

Small-scale

0.460

High

522259

HBA
Hemoglobin subunit alpha

1

0

Small-scale

0.460

High

522264

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

Small-scale

0.460

High

522274

CE162
Centrosomal protein of 162 kDa

1

0

Small-scale

0.460

High

522277

PLD3
5'-3' exonuclease PLD3

1

0

Small-scale

0.460

High

522283

NICA
Nicastrin

1

0

Small-scale

0.460

High

522285

CSN5
COP9 signalosome complex subunit 5

1

0

Small-scale

0.460

High

522289

CKLF3
CKLF-like MARVEL transmembrane domain-containing protein 3

1

0

Small-scale

0.460

High

522300

CC50A
Cell cycle control protein 50A

1

0

Small-scale

0.460

High

522302

C1RL
Complement C1r subcomponent-like protein

1

0

Small-scale

0.460

High

522308

NCKP1
Nck-associated protein 1

1

0

Small-scale

0.460

High

522309

AMOL2
Angiomotin-like protein 2

1

0

Small-scale

0.460

High

522310

RPGF2
Rap guanine nucleotide exchange factor 2

1

0

Small-scale

0.460

High

136794

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.458

High

486887

PARP1
Poly [ADP-ribose] polymerase 1

1

0

Small-scale

0.458

High

522284

RSCA1
Regulatory solute carrier protein family 1 member 1

1

0

Small-scale

0.458

High

522288

FA20A
Pseudokinase FAM20A

1

1

Small-scale

0.445

High

522260

MAP1A
Microtubule-associated protein 1A

1

3

Small-scale

0.439

High

522266

ZN638
Zinc finger protein 638

1

1

Small-scale

0.439

High

522291

TTC1
Tetratricopeptide repeat protein 1

1

2

Small-scale

0.439

High

522301

KCIP1
A-type potassium channel modulatory protein KCNIP1

1

1

Small-scale

0.439

High

522252

MEOX2
Homeobox protein MOX-2

1

0

High-throughput

0.299

High

522236

DRD2
D(2) dopamine receptor

1

0

High-throughput

0.282

High

522246

PE2R4
Prostaglandin E2 receptor EP4 subtype

1

0

High-throughput

0.282

High

522282

CTBL1
Beta-catenin-like protein 1

1

0

High-throughput

0.282

High

522297

PDLI7
PDZ and LIM domain protein 7

1

0

High-throughput

0.282

High

160042

CHD1
Chromodomain-helicase-DNA-binding protein 1

1

0

Small-scale

0.251

Low

184001

S22A1
Solute carrier family 22 member 1

1

0

Small-scale

0.251

Low

190698

MPPD1
Metallophosphoesterase domain-containing protein 1

1

0

Small-scale

0.251

Low

221230

DCX
Neuronal migration protein doublecortin

1

0

Small-scale

0.251

Low

344387

TBCD8
TBC1 domain family member 8

1

0

Small-scale

0.251

Low

424340

HMGN1
Non-histone chromosomal protein HMG-14

1

0

Small-scale

0.251

Low

430969

LA
Lupus La protein

1

0

Small-scale

0.251

Low

522240

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

0

Small-scale

0.251

Low

522243

RL13
Large ribosomal subunit protein eL13

1

0

Small-scale

0.251

Low

522247

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

Small-scale

0.251

Low

522254

SC24C
Protein transport protein Sec24C

1

0

Small-scale

0.251

Low

522255

RL15
Large ribosomal subunit protein eL15

1

0

Small-scale

0.251

Low

522263

S39A6
Zinc transporter ZIP6

1

0

Small-scale

0.251

Low

522268

BRD3
Bromodomain-containing protein 3

1

0

Small-scale

0.251

Low

522270

RM23
Large ribosomal subunit protein uL23m

1

0

Small-scale

0.251

Low

522271

GRAP1
GRIP1-associated protein 1

1

0

Small-scale

0.251

Low

522272

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

0

Small-scale

0.251

Low

522273

C2D1B
Coiled-coil and C2 domain-containing protein 1B

1

0

Small-scale

0.251

Low

522275

Z804A
Zinc finger protein 804A

1

0

Small-scale

0.251

Low

522276

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

0

Small-scale

0.251

Low

522279

DSEL
Dermatan-sulfate epimerase-like protein

1

0

Small-scale

0.251

Low

522280

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

Small-scale

0.251

Low

522281

COMD1
COMM domain-containing protein 1

1

0

Small-scale

0.251

Low

522287

CMIP5
Ciliary microtubule inner protein 5

1

0

Small-scale

0.251

Low

522290

RANB9
Ran-binding protein 9

1

0

Small-scale

0.251

Low

522292

EPAS1
Endothelial PAS domain-containing protein 1

1

0

Small-scale

0.251

Low

522293

TM168
Transmembrane protein 168

1

0

Small-scale

0.251

Low

522294

RIMS4
Regulating synaptic membrane exocytosis protein 4

1

0

Small-scale

0.251

Low

522295

UBP42
Ubiquitin carboxyl-terminal hydrolase 42

1

0

Small-scale

0.251

Low

522296

LRRC4
Leucine-rich repeat-containing protein 4

1

0

Small-scale

0.251

Low

522303

PEMT
Phosphatidylethanolamine N-methyltransferase

1

0

Small-scale

0.251

Low

522304

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

0

Small-scale

0.251

Low

522305

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

Small-scale

0.251

Low

522306

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

1

0

Small-scale

0.251

Low

522307

AFF4
AF4/FMR2 family member 4

1

0

Small-scale

0.251

Low

522261

TRAF3
TNF receptor-associated factor 3

1

0

Small-scale

0.249

Low

522262

SKP2
S-phase kinase-associated protein 2

1

0

Small-scale

0.249

Low

522267

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.249

Low

522269

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

522299

ABCF3
ATP-binding cassette sub-family F member 3

1

0

High-throughput

0.238

Low

132784

PK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025