HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: OTUD4 (Q01804)
OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1)
Gene: OTUD4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	28190767, 29576527, 38803224, 25944111, 23827681
Identification Methods	pull down, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	OTU~ubiquitin
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 1114
+	Mm
		70601 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		OTUD4_MOUSE (1-1114): 0: 1741: 87.19
+	Dm
		477516 UBIQP_DROME (1-610): 0: 752: 99.84		OTU_DROME (9-341): 8.92e-101: 340: 26.57
+	Hs
		475884 UBC_HUMAN (1-685): 0: 846: 100.00		OTUD3_HUMAN (22-253): 4.74e-63: 221: 24.60
+	Hs
		476196 UBC_HUMAN (1-685): 0: 846: 100.00		OTUD5_HUMAN (2-212): 3.8e-54: 201: 20.71
+	Hs
		475896 UBC_HUMAN (1-685): 0: 846: 100.00		OTU1_HUMAN (34-239): 1.93e-53: 192: 18.69
+	Hs
		475969 UBC_HUMAN (1-685): 0: 846: 100.00		OTU6A_HUMAN (18-168): 4.32e-46: 169: 22.29
+	Hs
		476050 UBC_HUMAN (1-685): 0: 846: 100.00		OTU6B_HUMAN (15-155): 8.25e-43: 159: 19.62
+	Hs
		475894 UBC_HUMAN (1-685): 0: 846: 100.00		OTUD1_HUMAN (21-198): 2.43e-37: 149: 23.66
+	Sc
		477333 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		OTU1_YEAST (34-237): 7.33e-47: 172: 18.05
+	Mm
		476788 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		OTUD5_MOUSE (2-212): 1.53e-55: 205: 21.17
+	Rn
		1104201 UBC_RAT (1-108): 1.27e-29: 127: 90.74		OTU1_RAT (34-239): 1.15e-52: 190: 18.22
+	Hs
		398002 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		OTU1_HUMAN (34-239): 1.93e-53: 192: 18.69