Protein: K2C6A
Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK-6A) (Cytokeratin-6D) (CK-6D) (Keratin-6A) (K6A) (Type-II keratin Kb6) (allergen Hom s 5)

Gene: K2C6A, KRT6A
Organism: Homo sapiens
Interactions: 164
UniProt ID: P02538

Gene Ontology (top 5):
GO:0002009 - morphogenesis of an epithelium
GO:0005200 - structural constituent of cytoskeleton
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0008284 - positive regulation of cell population proliferation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

385236

K1C15
Keratin, type I cytoskeletal 15

8

20

High-throughput

0.976

High

300714

KRT38
Keratin, type I cuticular Ha8

6

20

High-throughput

0.958

High

385287

K1C40
Keratin, type I cytoskeletal 40

5

20

High-throughput

0.942

High

385230

K1C13
Keratin, type I cytoskeletal 13

5

20

High-throughput

0.929

High

385278

K1H1
Keratin, type I cuticular Ha1

4

20

High-throughput

0.921

High

385261

K1C17
Keratin, type I cytoskeletal 17

3

20

High-throughput

0.845

High

385215

K1C18
Keratin, type I cytoskeletal 18

3

20

High-throughput

0.843

High

385220

K1C19
Keratin, type I cytoskeletal 19

3

20

High-throughput

0.843

High

385222

K1C16
Keratin, type I cytoskeletal 16

3

20

High-throughput

0.843

High

300280

KRT34
Keratin, type I cuticular Ha4

2

20

High-throughput

0.783

High

300541

KRT36
Keratin, type I cuticular Ha6

2

20

High-throughput

0.783

High

385294

K1C28
Keratin, type I cytoskeletal 28

2

20

High-throughput

0.783

High

385295

K1C27
Keratin, type I cytoskeletal 27

2

20

High-throughput

0.783

High

385296

K1C26
Keratin, type I cytoskeletal 26

2

20

High-throughput

0.783

High

385297

K1C25
Keratin, type I cytoskeletal 25

2

20

High-throughput

0.783

High

385308

KRT35
Keratin, type I cuticular Ha5

2

20

High-throughput

0.783

High

385322

TRI54
Tripartite motif-containing protein 54

5

20

High-throughput

0.726

High

385319

KIFC3
Kinesin-like protein KIFC3

4

9

High-throughput

0.700

High

385243

TRI23
E3 ubiquitin-protein ligase TRIM23

2

7

High-throughput

0.654

High

169382

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

7

High-throughput

0.646

High

385262

GOGA2
Golgin subfamily A member 2

4

7

High-throughput

0.644

High

49876

A1A4E9
Keratin 13

1

20

High-throughput

0.626

High

385334

TFP11
Tuftelin-interacting protein 11

3

4

High-throughput

0.625

High

385210

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

20

High-throughput

0.621

High

341719

K2C75
Keratin, type II cytoskeletal 75

1

20

High-throughput

0.618

High

385028

K1C14
Keratin, type I cytoskeletal 14

1

20

High-throughput

0.618

High

385214

K2C6B
Keratin, type II cytoskeletal 6B

1

20

High-throughput

0.618

High

385216

K2C8
Keratin, type II cytoskeletal 8

1

20

High-throughput

0.618

High

385219

VIME
Vimentin

1

20

High-throughput

0.618

High

385221

K2C7
Keratin, type II cytoskeletal 7

1

20

High-throughput

0.618

High

385226

K2C3
Keratin, type II cytoskeletal 3

1

19

High-throughput

0.618

High

385229

K1C10
Keratin, type I cytoskeletal 10

1

20

High-throughput

0.618

High

385231

K2C5
Keratin, type II cytoskeletal 5

1

20

High-throughput

0.618

High

385235

DESM
Desmin

1

20

High-throughput

0.618

High

385241

K1C20
Keratin, type I cytoskeletal 20

1

20

High-throughput

0.618

High

385242

K22E
Keratin, type II cytoskeletal 2 epidermal

1

19

High-throughput

0.618

High

385245

PERI
Peripherin

1

20

High-throughput

0.618

High

385249

K2C6C
Keratin, type II cytoskeletal 6C

1

19

High-throughput

0.618

High

385260

K22O
Keratin, type II cytoskeletal 2 oral

1

20

High-throughput

0.618

High

385273

K2C72
Keratin, type II cytoskeletal 72

1

20

High-throughput

0.618

High

385281

K2C71
Keratin, type II cytoskeletal 71

1

20

High-throughput

0.618

High

385286

K2C79
Keratin, type II cytoskeletal 79

1

20

High-throughput

0.618

High

385292

K2C74
Keratin, type II cytoskeletal 74

1

20

High-throughput

0.618

High

385298

K2C1B
Keratin, type II cytoskeletal 1b

1

20

High-throughput

0.618

High

385300

K2C73
Keratin, type II cytoskeletal 73

1

20

High-throughput

0.618

High

385317

K1C12
Keratin, type I cytoskeletal 12

1

20

High-throughput

0.618

High

385331

KRT84
Keratin, type II cuticular Hb4

1

20

High-throughput

0.618

High

385253

GEM
GTP-binding protein GEM

2

5

High-throughput

0.606

High

385321

BEX2
Protein BEX2

2

1

High-throughput

0.606

High

385279

CC85B
Coiled-coil domain-containing protein 85B

1

1

High-throughput

0.582

High

385256

NCALD
Neurocalcin-delta

2

0

High-throughput

0.580

High

385338

UBQL2
Ubiquilin-2

2

0

High-throughput

0.580

High

226658

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

6

High-throughput

0.573

High

385244

NUP62
Nuclear pore glycoprotein p62

2

5

High-throughput

0.553

High

385302

TXLNB
Beta-taxilin

2

20

High-throughput

0.553

High

385265

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

2

High-throughput

0.541

High

385211

ALBU
Albumin

1

3

High-throughput

0.536

High

385227

CFTR
Cystic fibrosis transmembrane conductance regulator

1

17

High-throughput

0.536

High

385267

CUL1
Cullin-1

1

20

High-throughput

0.536

High

385268

CUL2
Cullin-2

1

20

High-throughput

0.536

High

385275

FL2D
Pre-mRNA-splicing regulator WTAP

1

6

High-throughput

0.536

High

385299

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

14

High-throughput

0.536

High

385310

CSN5
COP9 signalosome complex subunit 5

1

16

High-throughput

0.536

High

385311

CUL5
Cullin-5

1

20

High-throughput

0.536

High

385318

TCHP
Trichoplein keratin filament-binding protein

1

11

Small-scale

0.527

High

385293

POGZ
Pogo transposable element with ZNF domain

1

2

High-throughput

0.515

High

215479

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.513

High

246378

KDM1A
Lysine-specific histone demethylase 1A

1

3

High-throughput

0.508

High

385342

WASC3
WASH complex subunit 3

1

2

High-throughput

0.494

High

385218

PDIA1
Protein disulfide-isomerase

1

0

High-throughput

0.493

High

104274

F5H3M2
Kinesin-like protein

1

9

High-throughput

0.483

High

385285

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

14

High-throughput

0.481

High

131274

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

11

Small-scale

0.479

High

141263

DDX3X
ATP-dependent RNA helicase DDX3X

1

6

Small-scale

0.479

High

209422

SERA
D-3-phosphoglycerate dehydrogenase

1

6

Small-scale

0.479

High

247591

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

271802

OBSL1
Obscurin-like protein 1

1

8

High-throughput

0.479

High

285023

EED
Polycomb protein EED

1

11

High-throughput

0.479

High

302300

RNF8
E3 ubiquitin-protein ligase RNF8

1

15

High-throughput

0.479

High

323072

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

High-throughput

0.479

High

324388

HEXI1
Protein HEXIM1

1

19

High-throughput

0.479

High

348924

LATS1
Serine/threonine-protein kinase LATS1

1

6

High-throughput

0.479

High

370873

MYC
Myc proto-oncogene protein

1

12

High-throughput

0.479

High

385212

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

8

High-throughput

0.479

High

385213

MYCN
N-myc proto-oncogene protein

1

12

High-throughput

0.479

High

385217

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

3

Small-scale

0.479

High

385223

F16P1
Fructose-1,6-bisphosphatase 1

1

4

High-throughput

0.479

High

385224

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

7

High-throughput

0.479

High

385228

ITA4
Integrin alpha-4

1

3

High-throughput

0.479

High

385232

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

9

Small-scale

0.479

High

385233

DESP
Desmoplakin

1

20

Small-scale

0.479

High

385239

CBL
E3 ubiquitin-protein ligase CBL

1

12

High-throughput

0.479

High

385240

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.479

High

385246

EPS15
Epidermal growth factor receptor substrate 15

1

13

High-throughput

0.479

High

385247

CRK
Adapter molecule crk

1

20

High-throughput

0.479

High

385248

YAP1
Transcriptional coactivator YAP1

1

18

High-throughput

0.479

High

385250

MECP2
Methyl-CpG-binding protein 2

1

6

High-throughput

0.479

High

385254

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.479

High

385257

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

9

High-throughput

0.479

High

385258

GRB2
Growth factor receptor-bound protein 2

1

18

High-throughput

0.479

High

385264

TFCP2
Alpha-globin transcription factor CP2

1

4

High-throughput

0.479

High

385266

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

High-throughput

0.479

High

385269

DX39B
Spliceosome RNA helicase DDX39B

1

20

High-throughput

0.479

High

385271

DCTN1
Dynactin subunit 1

1

16

High-throughput

0.479

High

385272

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.479

High

385276

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

385277

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

15

High-throughput

0.479

High

385280

EZH2
Histone-lysine N-methyltransferase EZH2

1

9

High-throughput

0.479

High

385283

LARP7
La-related protein 7

1

11

High-throughput

0.479

High

385284

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

6

High-throughput

0.479

High

385288

PRP8
Pre-mRNA-processing-splicing factor 8

1

8

High-throughput

0.479

High

385289

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

7

High-throughput

0.479

High

385291

MEPCE
7SK snRNA methylphosphate capping enzyme

1

11

High-throughput

0.479

High

385304

PAPD5
Terminal nucleotidyltransferase 4B

1

3

High-throughput

0.479

High

385305

TNIP2
TNFAIP3-interacting protein 2

1

4

High-throughput

0.479

High

385306

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

High-throughput

0.479

High

385307

TITIN
Titin

1

13

High-throughput

0.479

High

385309

HDAC2
Histone deacetylase 2

1

12

High-throughput

0.479

High

385312

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

7

Small-scale

0.479

High

385314

AP2M1
AP-2 complex subunit mu

1

8

High-throughput

0.479

High

385315

RNF31
E3 ubiquitin-protein ligase RNF31

1

16

High-throughput

0.479

High

385323

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.479

High

385326

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

385327

RN208
RING finger protein 208

1

20

Small-scale

0.479

High

385328

ATG5
Autophagy protein 5

1

3

High-throughput

0.479

High

385329

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

10

High-throughput

0.479

High

385330

ANLN
Anillin

1

11

High-throughput

0.479

High

385332

RNF12
E3 ubiquitin-protein ligase RLIM

1

15

High-throughput

0.479

High

385335

HDAC6
Protein deacetylase HDAC6

1

13

High-throughput

0.479

High

385337

ZRAN1
Ubiquitin thioesterase ZRANB1

1

12

High-throughput

0.479

High

385339

FZR1
Fizzy-related protein homolog

1

9

High-throughput

0.479

High

176114

PER2
Period circadian protein homolog 2

1

0

Small-scale

0.458

High

297389

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

High-throughput

0.458

High

345236

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

362553

EGFR
Epidermal growth factor receptor

1

7

Small-scale

0.445

High

379177

IGHG1
Immunoglobulin heavy constant gamma 1

1

8

High-throughput

0.445

High

385225

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.445

High

385237

VCAM1
Vascular cell adhesion protein 1

1

6

High-throughput

0.445

High

385255

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

385259

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

6

High-throughput

0.445

High

385263

LG3BP
Galectin-3-binding protein

1

8

High-throughput

0.445

High

385270

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

6

High-throughput

0.445

High

385325

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

High-throughput

0.445

High

385324

TSG10
Testis-specific gene 10 protein

1

8

High-throughput

0.439

High

105072

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

293020

CD123
Translation initiation factor eIF2 assembly protein

1

8

High-throughput

0.437

High

385234

TIMP2
Metalloproteinase inhibitor 2

1

6

High-throughput

0.437

High

385238

EFNA1
Ephrin-A1

1

20

High-throughput

0.437

High

385251

EFNA3
Ephrin-A3

1

20

High-throughput

0.437

High

385252

EFNA4
Ephrin-A4

1

20

High-throughput

0.437

High

385274

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

2

High-throughput

0.437

High

385282

MINY4
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

1

3

Small-scale

0.437

High

385290

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

385316

DIRA2
GTP-binding protein Di-Ras2

1

2

Small-scale

0.437

High

385320

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

6

High-throughput

0.437

High

385333

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

3

High-throughput

0.437

High

385336

KS6B2
Ribosomal protein S6 kinase beta-2

1

6

High-throughput

0.437

High

385340

PHTF1
Protein PHTF1

1

9

High-throughput

0.437

High

385341

AAR2
Protein AAR2 homolog

1

6

High-throughput

0.437

High

874

SIM26
Small integral membrane protein 26

1

6

High-throughput

0.407

High

109141

G4U4J3
Terminal nucleotidyltransferase 4B

1

3

High-throughput

0.407

High

385301

SULF2
Extracellular sulfatase Sulf-2

1

9

High-throughput

0.407

High

385303

MOT11
Monocarboxylate transporter 11

1

3

High-throughput

0.407

High

385313

PP14B
Protein phosphatase 1 regulatory subunit 14B

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025