HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: CBLB (Q13191)
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
Gene: CBLB

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.965

Property	Details
Experiments	30659753, 31699778, 19880507, 19285159, 18596201, 16007098, 14661060
Identification Methods	unspecified method, pull down, enzymatic study, protein array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cbl_N3~ubiquitin, ubiquitin~zf-C3HC4
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016567 - protein ubiquitination
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 982
+	Hs
		475339 UBC_HUMAN (1-685): 0: 846: 100.00		CBL_HUMAN (25-976): 0: 675: 47.10
+	Hs
		476560 UBC_HUMAN (1-685): 0: 846: 100.00		CBLC_HUMAN (29-497): 0: 585: 44.65
+	Mm
		476784 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		CBLB_MOUSE (1-982): 0: 873: 95.12
+	Hs
		475943 UBC_HUMAN (1-685): 0: 846: 100.00		OTOG_HUMAN (342-681): 8.12e-10: 65.4: 10.41
+	Hs
		610336 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		CBL_HUMAN (25-976): 0: 675: 47.10
+	Rn
		88778 UBC_RAT (1-108): 1.27e-29: 127: 90.74		D3ZV15_RAT (25-931): 0: 647: 48.11
+	At
		1092118 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		Q9LIE8_ARATH (415-980): 4.44e-20: 98.6: 11.07
+	Rn
		1144063 UBC_RAT (1-108): 1.27e-29: 127: 90.74		SYNJ1_RAT (687-978): 9.27e-09: 62: 10.51