HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: TIF1B (Q13263)
Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)
Gene: TRIM28

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	16196087, 31028095, 20864041
Identification Methods	affinity chromatography technology, x-ray crystallography, enzymatic study
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	ubiquitin~zf-RING_5
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 835
+	Hs
		175634 UBC_HUMAN (1-685): 0: 846: 100.00		TRI18_HUMAN (56-644): 5.73e-67: 237: 13.78
+	Hs
		475374 UBC_HUMAN (1-685): 0: 846: 100.00		PML_HUMAN (29-609): 1.21e-57: 214: 14.00
+	Hs
		475423 UBC_HUMAN (1-685): 0: 846: 100.00		TRI23_HUMAN (38-421): 2.37e-56: 205: 14.42
+	Hs
		476427 UBC_HUMAN (1-685): 0: 846: 100.00		TRI36_HUMAN (50-425): 1.95e-52: 197: 14.87
+	Hs
		476330 UBC_HUMAN (1-685): 0: 846: 100.00		TRIM5_HUMAN (113-541): 7.42e-50: 185: 13.04
+	Hs
		475328 UBC_HUMAN (1-685): 0: 846: 100.00		RO52_HUMAN (104-502): 1.58e-48: 180: 12.94
+	Xl
		1186351 Q7SY79_XENLA (77-685): 0: 744: 99.84		NF7B_XENLA (9-446): 9.38e-52: 193: 12.70
+	Dr
		91588 F1QHN6_DANRE (229-685): 0: 555: 99.78		E7F1U3_DANRE (37-628): 1.73e-59: 218: 16.56
+	Hs
		923976 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Rn
		139629 UBC_RAT (1-108): 1.27e-29: 127: 90.74		TIF1B_RAT (57-835): 4.06e-159: 486: 94.87
+	Hs
		1029457 OASL_HUMAN (1-153): 6.51e-17: 86.3: 29.11		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		668577 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		PML_HUMAN (29-609): 1.21e-57: 214: 14.00
+	Hs
		734585 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		TRI23_HUMAN (38-421): 2.37e-56: 205: 14.42
+	Hs
		170323 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		TIF1A_HUMAN (404-808): 1.31e-52: 200: 21.55
+	Mm
		476823 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		PML_MOUSE (48-609): 1.25e-55: 208: 16.15
+	Rn
		88684 UBC_RAT (1-108): 1.27e-29: 127: 90.74		TRIM2_RAT (109-628): 4.38e-52: 196: 14.63
+	Hs
		475200 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		TRI36_HUMAN (50-425): 1.95e-52: 197: 14.87
+	Hs
		475177 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		TRIM5_HUMAN (113-541): 7.42e-50: 185: 13.04