HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: BRE1A (Q5VTR2)
E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A)
Gene: RNF20

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17550899
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ubiquitin~zf-C3HC4
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 975
+	Hs
		475417 UBC_HUMAN (1-685): 0: 846: 100.00		MYH9_HUMAN (235-957): 1.06e-32: 139: 11.26
+	Hs
		475291 UBC_HUMAN (1-685): 0: 846: 100.00		MYH1_HUMAN (1-596): 3.5e-23: 109: 12.48
+	At
		1091974 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		BRE1B_ARATH (45-974): 3.82e-68: 247: 19.98
+	Hs
		256207 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		BRE1B_HUMAN (1-974): 4.61e-62: 230: 56.49
+	Hs
		397813 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		MYH9_HUMAN (235-957): 1.06e-32: 139: 11.26
+	Hs
		148651 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		CTRO_HUMAN (49-890): 9.97e-15: 81.5: 14.94
+	Mm
		476828 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		MYH10_MOUSE (574-929): 7.35e-14: 78.7: 12.92
+	Hs
		64575 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		MYH7B_HUMAN (1-624): 4.62e-17: 89.1: 11.62
+	Mm
		476930 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		MYH9_MOUSE (1-355): 3.58e-12: 72.9: 10.31
+	Hs
		397814 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		MYH10_HUMAN (604-944): 1.39e-12: 74.4: 10.85
+	Hs
		398052 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		MY18A_HUMAN (326-919): 1.43e-10: 67.7: 15.69
+	Hs
		148861 OASL_HUMAN (1-153): 6.51e-17: 86.3: 29.11		CTRO_HUMAN (49-890): 9.97e-15: 81.5: 14.94