HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: WDR48 (Q8TAF3)
WD repeat-containing protein 48 (USP1-associated factor 1) (WD repeat endosomal protein) (p80)
Gene: WDR48

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.585

Property	Details
Experiments	26388029, 30576655
Identification Methods	x-ray crystallography, enzymatic study
Interaction Type	association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 677
+	Dm
		477542 UBIQP_DROME (1-610): 0: 752: 99.84		FBXW7_DROME (61-402): 7.05e-82: 284: 23.62
+	Hs
		476181 UBC_HUMAN (1-685): 0: 846: 100.00		SNR40_HUMAN (202-466): 3.02e-53: 188: 15.13
+	Hs
		475563 UBC_HUMAN (1-685): 0: 846: 100.00		WDR5_HUMAN (244-509): 1.61e-43: 161: 13.70
+	Hs
		196947 UBC_HUMAN (1-685): 0: 846: 100.00		PRP4_HUMAN (238-427): 5.8e-22: 101: 7.87
+	Hs
		476547 UBC_HUMAN (1-685): 0: 846: 100.00		FBW1B_HUMAN (11-282): 1.55e-18: 91.3: 28.68
+	Hs
		476151 UBC_HUMAN (1-685): 0: 846: 100.00		FBXW7_HUMAN (330-498): 9.76e-09: 60.4: 10.06
+	Sc
		477239 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		TAF5_YEAST (25-229): 2.78e-36: 147: 18.45
+	At
		187391 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		O22826_ARATH (286-532): 1.01e-20: 95.9: 11.29
+	At
		1091956 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		GPLPB_ARATH (44-241): 3.04e-13: 73.2: 28.18
+	At
		1092188 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		GPLPC_ARATH (44-241): 1.37e-12: 71.2: 27.27
+	Hs
		903105 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		WDR5_HUMAN (244-509): 1.61e-43: 161: 13.70
+	Hs
		863401 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		COPA_HUMAN (203-395): 9.79e-18: 90.1: 16.50
+	Mm
		476899 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		TBL3_MOUSE (47-276): 8.1e-20: 96.3: 24.19
+	Rn
		102492 UBC_RAT (1-108): 1.27e-29: 127: 90.74		G3V6T1_RAT (203-387): 8.11e-19: 93.5: 14.66
+	Rn
		925834 UBC_RAT (1-108): 1.27e-29: 127: 90.74		LIS1_RAT (327-569): 5.7e-15: 79.3: 9.76
+	Hs
		397862 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		COPA_HUMAN (203-395): 9.79e-18: 90.1: 16.50
+	Hs
		397828 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		LIS1_HUMAN (327-569): 6.18e-15: 79.3: 9.76