Protein: PTSS1
Phosphatidylserine synthase 1 (PSS-1) (PtdSer synthase 1) (EC 2.7.8.29) (Serine-exchange enzyme I)

Gene: PTSS1, PTDSS1
Organism: Homo sapiens
Interactions: 206
UniProt ID: P48651

Gene Ontology (top 5):
GO:0005789 - endoplasmic reticulum membrane
GO:0006659 - phosphatidylserine biosynthetic process
GO:0016020 - membrane
GO:0016740 - transferase activity
GO:0106245 - L-serine-phosphatidylethanolamine phosphatidyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

369173

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

216689

CREB3
Cyclic AMP-responsive element-binding protein 3

2

0

High-throughput

0.565

High

821535

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.559

High

665828

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

0

High-throughput

0.547

High

234199

PEPL
Periplakin

1

3

High-throughput

0.536

High

452209

HMOX1
Heme oxygenase 1

1

1

High-throughput

0.536

High

572316

LEG3
Galectin-3

1

1

High-throughput

0.536

High

611219

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

1

High-throughput

0.536

High

646142

STOM
Stomatin

1

2

High-throughput

0.536

High

821534

EPIPL
Epiplakin

1

4

High-throughput

0.536

High

821561

ACOX1
Peroxisomal acyl-coenzyme A oxidase 1

1

1

High-throughput

0.536

High

821577

MBOA5
Lysophospholipid acyltransferase 5

1

1

High-throughput

0.536

High

821593

RDHE2
Epidermal retinol dehydrogenase 2

1

1

High-throughput

0.536

High

821601

EVPL
Envoplakin

1

4

High-throughput

0.536

High

175343

LX15B
Polyunsaturated fatty acid lipoxygenase ALOX15B

1

0

High-throughput

0.513

High

383688

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

0

High-throughput

0.513

High

815749

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

0

High-throughput

0.513

High

816352

PPCE
Prolyl endopeptidase

1

0

High-throughput

0.513

High

821570

CAHM4
Calcium homeostasis modulator protein 4

1

0

High-throughput

0.513

High

821572

ATG9B
Autophagy-related protein 9B

1

0

High-throughput

0.513

High

821583

GDPD3
Lysophospholipase D GDPD3

1

0

High-throughput

0.513

High

821584

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

0

High-throughput

0.513

High

821603

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.513

High

821611

GSDMA
Gasdermin-A

1

0

High-throughput

0.513

High

821620

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

821639

NEUR2
Sialidase-2

1

0

High-throughput

0.513

High

560492

TSHR
Thyrotropin receptor

1

4

High-throughput

0.494

High

82392

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

4

High-throughput

0.489

High

128979

PLK4
Serine/threonine-protein kinase PLK4

1

1

High-throughput

0.489

High

198418

KLK10
Kallikrein-10

1

1

High-throughput

0.489

High

245799

CATL2
Cathepsin L2

1

1

High-throughput

0.489

High

260796

H2AY
Core histone macro-H2A.1

1

2

High-throughput

0.489

High

334352

AL1A1
Aldehyde dehydrogenase 1A1

1

1

High-throughput

0.489

High

376191

ANXA1
Annexin A1

1

1

High-throughput

0.489

High

396331

APOD
Apolipoprotein D

1

1

High-throughput

0.489

High

396705

S10A8
Protein S100-A8

1

7

High-throughput

0.489

High

431190

CATB
Cathepsin B

1

2

High-throughput

0.489

High

453956

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

1

High-throughput

0.489

High

533201

PLSL
Plastin-2

1

1

High-throughput

0.489

High

533965

ANXA8
Annexin A8

1

1

High-throughput

0.489

High

551636

DESP
Desmoplakin

1

4

High-throughput

0.489

High

596259

FILA
Filaggrin

1

4

High-throughput

0.489

High

600748

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

6

High-throughput

0.489

High

638940

S100P
Protein S100-P

1

8

High-throughput

0.489

High

667929

SPB3
Serpin B3

1

2

High-throughput

0.489

High

678423

S10A7
Protein S100-A7

1

8

High-throughput

0.489

High

707359

S10A3
Protein S100-A3

1

8

High-throughput

0.489

High

738733

SPB5
Serpin B5

1

2

High-throughput

0.489

High

814360

AL1A3
Retinaldehyde dehydrogenase 3

1

1

High-throughput

0.489

High

814919

LEG7
Galectin-7

1

1

High-throughput

0.489

High

820284

SPB4
Serpin B4

1

2

High-throughput

0.489

High

821530

KLK7
Kallikrein-7

1

1

High-throughput

0.489

High

821544

SRPK2
SRSF protein kinase 2

1

1

High-throughput

0.489

High

821547

NGAL
Neutrophil gelatinase-associated lipocalin

1

1

High-throughput

0.489

High

821552

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

1

High-throughput

0.489

High

821555

PKP1
Plakophilin-1

1

2

High-throughput

0.489

High

821562

PLEC
Plectin

1

2

High-throughput

0.489

High

821569

FILA2
Filaggrin-2

1

5

High-throughput

0.489

High

821580

CAN12
Calpain-12

1

1

High-throughput

0.489

High

821586

S1A7A
Protein S100-A7A

1

8

High-throughput

0.489

High

821596

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

1

High-throughput

0.489

High

821598

LRC15
Leucine-rich repeat-containing protein 15

1

1

High-throughput

0.489

High

821606

S10AG
Protein S100-A16

1

8

High-throughput

0.489

High

821610

CPNS2
Calpain small subunit 2

1

3

High-throughput

0.489

High

821612

SRPK1
SRSF protein kinase 1

1

1

High-throughput

0.489

High

821622

S10AE
Protein S100-A14

1

7

High-throughput

0.489

High

821629

CALL5
Calmodulin-like protein 5

1

1

High-throughput

0.489

High

821640

PKP3
Plakophilin-3

1

2

High-throughput

0.489

High

821550

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

0

High-throughput

0.479

High

436201

RHOC
Rho-related GTP-binding protein RhoC

1

5

High-throughput

0.479

High

506921

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.479

High

527343

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

545258

RAC2
Ras-related C3 botulinum toxin substrate 2

1

5

High-throughput

0.479

High

718613

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

821533

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

821537

CDC42
Cell division control protein 42 homolog

1

6

High-throughput

0.479

High

821538

RHOA
Transforming protein RhoA

1

6

High-throughput

0.479

High

821542

RAC1
Ras-related C3 botulinum toxin substrate 1

1

6

High-throughput

0.479

High

821548

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.479

High

821568

TM41B
Transmembrane protein 41B

1

1

High-throughput

0.479

High

821573

RNF43
E3 ubiquitin-protein ligase RNF43

1

1

High-throughput

0.479

High

821609

DNJC1
DnaJ homolog subfamily C member 1

1

2

High-throughput

0.479

High

821618

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.479

High

294516

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

298271

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

304065

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

High-throughput

0.458

High

319758

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

322326

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

390115

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

390766

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

795065

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

821541

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

821551

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.458

High

821560

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

821566

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.458

High

821604

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

821608

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

821613

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

821625

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

821626

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

821628

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

821630

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

821632

SEC63
Translocation protein SEC63 homolog

1

0

High-throughput

0.458

High

120343

RHOD
Rho-related GTP-binding protein RhoD

1

8

High-throughput

0.437

High

205165

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

779004

CCNF
Cyclin-F

1

1

High-throughput

0.437

High

821532

RND2
Rho-related GTP-binding protein RhoN

1

7

High-throughput

0.437

High

821563

RHOH
Rho-related GTP-binding protein RhoH

1

6

High-throughput

0.437

High

821565

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

1

High-throughput

0.437

High

821576

TECT3
Tectonic-3

1

2

High-throughput

0.437

High

821581

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

821585

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

821594

DHB11
Estradiol 17-beta-dehydrogenase 11

1

1

High-throughput

0.437

High

821600

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

821607

TECT2
Tectonic-2

1

2

High-throughput

0.437

High

821619

RHOJ
Rho-related GTP-binding protein RhoJ

1

6

High-throughput

0.437

High

821621

RHOF
Rho-related GTP-binding protein RhoF

1

7

High-throughput

0.437

High

821638

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.437

High

484270

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

0

High-throughput

0.426

High

821595

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.426

High

87549

C9JUP7
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.407

High

353504

IGKC
Immunoglobulin kappa constant

1

4

High-throughput

0.407

High

353652

IGHG1
Immunoglobulin heavy constant gamma 1

1

4

High-throughput

0.407

High

353764

IGHG2
Immunoglobulin heavy constant gamma 2

1

4

High-throughput

0.407

High

474413

IGLC6
Immunoglobulin lambda constant 6

1

4

High-throughput

0.407

High

153005

IMPA2
Inositol monophosphatase 2

1

0

High-throughput

0.279

Low

271829

CREG1
Protein CREG1

1

0

High-throughput

0.279

Low

304937

DUS14
Dual specificity protein phosphatase 14

1

0

High-throughput

0.279

Low

315465

G6PE
GDH/6PGL endoplasmic bifunctional protein [Includes: Hexose-6-phosphate dehydrogenase

1

0

High-throughput

0.279

Low

329489

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.279

Low

344648

CO3
Complement C3

1

0

High-throughput

0.279

Low

358988

CRYAB
Alpha-crystallin B chain

1

0

High-throughput

0.279

Low

363432

A1AG1
Alpha-1-acid glycoprotein 1

1

0

High-throughput

0.279

Low

363738

ALBU
Albumin

1

0

High-throughput

0.279

Low

364535

TRFE
Serotransferrin

1

0

High-throughput

0.279

Low

364779

HEMO
Hemopexin

1

0

High-throughput

0.279

Low

396207

ARGI1
Arginase-1

1

0

High-throughput

0.279

Low

413858

GELS
Gelsolin

1

0

High-throughput

0.279

Low

428567

INVO
Involucrin

1

0

High-throughput

0.279

Low

507551

PIM1
Serine/threonine-protein kinase pim-1

1

0

High-throughput

0.279

Low

542234

PLAK
Junction plakoglobin

1

0

High-throughput

0.279

Low

546827

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.279

Low

559020

H15
Histone H1.5

1

0

High-throughput

0.279

Low

572114

SAP3
Ganglioside GM2 activator

1

0

High-throughput

0.279

Low

577482

IL1RA
Interleukin-1 receptor antagonist protein

1

0

High-throughput

0.279

Low

588410

TYPH
Thymidine phosphorylase

1

0

High-throughput

0.279

Low

648477

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

656044

PSB8
Proteasome subunit beta type-8

1

0

High-throughput

0.279

Low

683052

CASPE
Caspase-14

1

0

High-throughput

0.279

Low

793669

CACP
Carnitine O-acetyltransferase

1

0

High-throughput

0.279

Low

821529

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

821531

PLCD1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

1

0

High-throughput

0.279

Low

821539

NPC2
NPC intracellular cholesterol transporter 2

1

0

High-throughput

0.279

Low

821545

NTH
Endonuclease III-like protein 1

1

0

High-throughput

0.279

Low

821546

PHLD
Phosphatidylinositol-glycan-specific phospholipase D

1

0

High-throughput

0.279

Low

821549

DIAC
Di-N-acetylchitobiase

1

0

High-throughput

0.279

Low

821553

ASAH1
Acid ceramidase

1

0

High-throughput

0.279

Low

821556

TRI29
Tripartite motif-containing protein 29

1

0

High-throughput

0.279

Low

821564

CYTM
Cystatin-M

1

0

High-throughput

0.279

Low

821567

PA24E
Cytosolic phospholipase A2 epsilon

1

0

High-throughput

0.279

Low

821574

HPHL1
Ferroxidase HEPHL1

1

0

High-throughput

0.279

Low

821575

SAPL1
Proactivator polypeptide-like 1 [Cleaved into: Saposin A-like; Saposin B-Val-like; Saposin B-like; Saposin C-like; Saposin D-like]

1

0

High-throughput

0.279

Low

821578

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.279

Low

821582

FBX50
F-box only protein 50

1

0

High-throughput

0.279

Low

821587

LYG2
Lysozyme g-like protein 2

1

0

High-throughput

0.279

Low

821588

DSG4
Desmoglein-4

1

0

High-throughput

0.279

Low

821591

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

821599

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low

821602

DNSL2
Deoxyribonuclease-1-like 2

1

0

High-throughput

0.279

Low

821617

RNAS7
Ribonuclease 7

1

0

High-throughput

0.279

Low

821624

PDLI7
PDZ and LIM domain protein 7

1

0

High-throughput

0.279

Low

821633

PCYOX
Prenylcysteine oxidase 1

1

0

High-throughput

0.279

Low

821634

DPP2
Dipeptidyl peptidase 2

1

0

High-throughput

0.279

Low

821635

CBPA4
Carboxypeptidase A4

1

0

High-throughput

0.279

Low

821636

CLC4K
C-type lectin domain family 4 member K

1

0

High-throughput

0.279

Low

821637

PADI3
Protein-arginine deiminase type-3

1

0

High-throughput

0.279

Low

821641

CRBG1
Beta/gamma crystallin domain-containing protein 1

1

0

High-throughput

0.279

Low

821642

FCGBP
IgGFc-binding protein

1

0

High-throughput

0.279

Low

821536

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

High-throughput

0.261

Low

47754

RBM47
RNA-binding protein 47

1

0

High-throughput

0.249

Low

122560

MEN1
Menin

1

0

High-throughput

0.249

Low

226820

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.249

Low

552199

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

650638

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

669923

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.249

Low

719940

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

821528

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

821540

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

821543

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

821557

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

821559

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.249

Low

821579

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

821590

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.249

Low

821592

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.249

Low

821597

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

821605

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

821614

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.249

Low

821615

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.249

Low

821616

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

High-throughput

0.249

Low

821623

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.249

Low

821627

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.249

Low

821631

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

821554

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.232

Low

821558

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.232

Low

821571

H37
Histone H3-7

1

0

High-throughput

0.232

Low

821589

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024