HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: SYNE2 (Q8WXH0)
Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2)
Gene: SYNE2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	27182664, 23314748
Identification Methods	proximity labelling technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0070062 - extracellular exosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 6885
+	Hs
		476576 UBC_HUMAN (1-685): 0: 846: 100.00		MACF1_HUMAN (279-2502): 1.13e-48: 197: 10.79
+	Hs
		475789 UBC_HUMAN (1-685): 0: 846: 100.00		PLEC_HUMAN (4832-6877): 3.53e-41: 172: 10.20
+	Mm
		477041 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		PLEC_MOUSE (3756-6188): 4.97e-48: 195: 9.31
+	Hs
		475141 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		CLMN_HUMAN (18-283): 7.62e-50: 198: 47.06
+	Hs
		397977 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		PLEC_HUMAN (4832-6877): 3.53e-41: 172: 10.20
+	Rn
		1144216 UBC_RAT (1-108): 1.27e-29: 127: 90.74		Q6XD99_RAT (5850-6832): 8.12e-19: 98.4: 12.16
+	Mm
		476949 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		DYST_MOUSE (5912-6875): 2.15e-12: 77.2: 8.60
+	Rn
		1144315 UBC_RAT (1-108): 1.27e-29: 127: 90.74		ACTN1_RAT (4678-5164): 6.48e-11: 71.7: 11.11
+	Mm
		476860 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		ACTN1_MOUSE (4678-5164): 2.82e-10: 69.8: 10.92
+	Hs
		397748 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		ACTN1_HUMAN (4678-5164): 1.7e-10: 70.6: 10.92
+	Hs
		475070 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		SYNE3_HUMAN (4445-5053): 1.36e-10: 70.7: 13.84