HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.916

Property	Details
Experiments	19111555, 18680311, 24039852, 17244534
Identification Methods	x-ray crystallography, pull down, nuclear magnetic resonance
Interaction Type	association, direct interaction

Property	Details
Interacting Pfam domains	SH3_9~ubiquitin
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 665
+	Hs
		476640 UBC_HUMAN (1-685): 0: 846: 100.00		CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22
+	Hs
		475592 UBC_HUMAN (1-685): 0: 846: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		476483 UBC_HUMAN (1-685): 0: 846: 100.00		ITSN2_HUMAN (30-455): 2.08e-26: 117: 15.30
+	Hs
		475816 UBC_HUMAN (1-685): 0: 846: 100.00		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Hs
		475936 UBC_HUMAN (1-685): 0: 846: 100.00		DNMBP_HUMAN (104-607): 3.03e-16: 85.1: 15.82
+	Hs
		208981 UBC_HUMAN (1-685): 0: 846: 100.00		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Hs
		476095 UBC_HUMAN (1-685): 0: 846: 100.00		SH3R3_HUMAN (197-627): 1.12e-12: 73.6: 12.19
+	Hs
		475981 UBC_HUMAN (1-685): 0: 846: 100.00		SH3R1_HUMAN (241-599): 5.37e-12: 71.2: 13.28
+	Xl
		1155575 Q7SY79_XENLA (77-685): 0: 744: 99.84		SH3R1_XENLA (228-495): 1.9e-11: 69.3: 14.44
+	Hs
		557653 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		923946 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Rn
		924996 UBC_RAT (1-108): 1.27e-29: 127: 90.74		GRB2_RAT (2-158): 6.97e-33: 128: 19.91
+	Hs
		474986 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Mm
		477062 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		ITSN1_MOUSE (120-519): 1.9e-19: 95.5: 14.11
+	Mm
		70590 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		B2RR82_MOUSE (203-394): 1.76e-16: 85.9: 15.54