Protein: TLE1
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)

Gene: TLE1
Organism: Homo sapiens
Interactions: 209
UniProt ID: Q04724

Gene Ontology (top 5):
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005667 - transcription regulator complex
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1047796

TLE2
Transducin-like enhancer protein 2

5

17

Small-scale

0.924

High

1047797

TLE3
Transducin-like enhancer protein 3

5

17

High-throughput

0.912

High

1047798

TLE4
Transducin-like enhancer protein 4

5

18

Small-scale

0.912

High

1047802

TLE5
TLE family member 5

4

16

Small-scale

0.887

High

1047795

TLE1
Transducin-like enhancer protein 1

3

17

Small-scale

0.875

High

1047799

HME1
Homeobox protein engrailed-1

5

20

Small-scale

0.716

High

1047816

HES1
Transcription factor HES-1

5

20

Small-scale

0.711

High

639597

SAT1
Diamine acetyltransferase 1

1

1

High-throughput

0.698

High

783146

ARL3
ADP-ribosylation factor-like protein 3

1

7

High-throughput

0.698

High

1047822

PA1B3
Platelet-activating factor acetylhydrolase IB subunit alpha1

1

3

High-throughput

0.698

High

1047827

EZH2
Histone-lysine N-methyltransferase EZH2

1

18

Small-scale

0.691

High

937620

FOXG1
Forkhead box protein G1

4

20

Small-scale

0.680

High

330129

VENTX
Homeobox protein VENTX

3

20

High-throughput

0.669

High

1047854

HES6
Transcription cofactor HES-6

3

20

Small-scale

0.669

High

224981

TLX3
T-cell leukemia homeobox protein 3

3

20

Small-scale

0.661

High

665253

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

1

High-throughput

0.656

High

1047815

GRB7
Growth factor receptor-bound protein 7

1

10

High-throughput

0.656

High

1047884

TBX20
T-box transcription factor TBX20

3

20

High-throughput

0.656

High

979538

H4
Histone H4

1

8

Small-scale

0.647

High

1047810

HDAC1
Histone deacetylase 1

2

20

Small-scale

0.639

High

1047820

DAZP2
DAZ-associated protein 2

3

1

High-throughput

0.639

High

820529

IL6RB
Interleukin-6 receptor subunit beta

1

5

Small-scale

0.637

High

1047882

LEF1
Lymphoid enhancer-binding factor 1

2

20

Small-scale

0.635

High

337924

SIX6
Homeobox protein SIX6

2

20

Small-scale

0.626

High

886264

ARL4D
ADP-ribosylation factor-like protein 4D

1

5

High-throughput

0.625

High

725244

TLX1
T-cell leukemia homeobox protein 1

2

20

Small-scale

0.624

High

405439

KITH
Thymidine kinase, cytosolic

2

1

High-throughput

0.620

High

331745

MTMR5
Myotubularin-related protein 5

1

3

High-throughput

0.618

High

822626

VHL
von Hippel-Lindau disease tumor suppressor

1

1

High-throughput

0.618

High

1047843

RHG24
Rho GTPase-activating protein 24

1

6

High-throughput

0.618

High

226537

TLX2
T-cell leukemia homeobox protein 2

2

20

High-throughput

0.614

High

938435

PAX9
Paired box protein Pax-9

2

20

High-throughput

0.614

High

1047805

RIPP1
Protein ripply1

2

19

High-throughput

0.611

High

1047817

HLX
H2.0-like homeobox protein

2

20

High-throughput

0.611

High

1047834

RIPP2
Protein ripply2

2

19

High-throughput

0.611

High

1047888

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

2

20

Small-scale

0.611

High

587452

TFE2
Transcription factor E2-alpha

2

8

Small-scale

0.602

High

1047818

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.601

High

1047839

MAEA
E3 ubiquitin-protein transferase MAEA

2

3

High-throughput

0.601

High

1047842

FXL14
F-box/LRR-repeat protein 14

2

5

High-throughput

0.601

High

241461

PRKN
E3 ubiquitin-protein ligase parkin

2

14

High-throughput

0.601

High

1047886

FOXA2
Hepatocyte nuclear factor 3-beta

2

20

Small-scale

0.601

High

289137

PRDM1
PR domain zinc finger protein 1

2

6

Small-scale

0.595

High

142953

NFIB
Nuclear factor 1 B-type

2

20

High-throughput

0.584

High

473932

NFIC
Nuclear factor 1 C-type

2

20

High-throughput

0.584

High

872234

SOX2
Transcription factor SOX-2

2

20

Small-scale

0.584

High

1047806

NFIA
Nuclear factor 1 A-type

2

20

High-throughput

0.584

High

1029805

RUNX1
Runt-related transcription factor 1

1

10

Small-scale

0.582

High

1047812

RUNX3
Runt-related transcription factor 3

1

10

Small-scale

0.582

High

285229

EED
Polycomb protein EED

1

18

Small-scale

0.575

High

1047819

SUZ12
Polycomb protein SUZ12

1

1

Small-scale

0.575

High

1040480

HHEX
Hematopoietically-expressed homeobox protein HHEX

1

20

Small-scale

0.573

High

1047852

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

2

Small-scale

0.573

High

1047866

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

4

Small-scale

0.573

High

1047880

HESX1
Homeobox expressed in ES cells 1

1

20

Small-scale

0.561

High

583539

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

10

Small-scale

0.554

High

1047837

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.553

High

1047864

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.553

High

935715

MFAP4
Microfibril-associated glycoprotein 4

2

7

High-throughput

0.549

High

127935

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

2

High-throughput

0.541

High

459556

PROF1
Profilin-1

1

1

High-throughput

0.541

High

588516

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.541

High

627640

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

2

High-throughput

0.541

High

772150

MSX2
Homeobox protein MSX-2

1

20

High-throughput

0.541

High

842953

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

7

High-throughput

0.541

High

895481

SPB9
Serpin B9

1

3

High-throughput

0.541

High

916085

NKX25
Homeobox protein Nkx-2.5

1

20

High-throughput

0.541

High

937721

FOXA1
Hepatocyte nuclear factor 3-alpha

1

20

High-throughput

0.541

High

938010

FOXA3
Hepatocyte nuclear factor 3-gamma

1

20

High-throughput

0.541

High

938528

CCL18
C-C motif chemokine 18

1

3

High-throughput

0.541

High

974117

RUXG
Small nuclear ribonucleoprotein G

1

19

High-throughput

0.541

High

1015185

ERH
Enhancer of rudimentary homolog

1

1

High-throughput

0.541

High

1047833

CELF3
CUGBP Elav-like family member 3

1

3

High-throughput

0.541

High

1047844

RNF10
E3 ubiquitin-protein ligase RNF10

1

5

High-throughput

0.541

High

1047850

FUBP1
Far upstream element-binding protein 1

1

15

High-throughput

0.541

High

1047859

BTBD2
BTB/POZ domain-containing protein 2

1

4

High-throughput

0.541

High

1047860

BARH1
BarH-like 1 homeobox protein

1

20

High-throughput

0.541

High

587059

ITF2
Transcription factor 4

1

8

Small-scale

0.536

High

216149

TBX1
T-box transcription factor TBX1

1

20

High-throughput

0.536

High

604642

UBF1
Nucleolar transcription factor 1

1

20

Small-scale

0.536

High

624539

HME2
Homeobox protein engrailed-2

1

20

High-throughput

0.536

High

943467

DSCR6
Protein ripply3

1

19

High-throughput

0.536

High

944797

PCBP3
Poly(rC)-binding protein 3

1

11

High-throughput

0.536

High

1047811

CUL4B
Cullin-4B

1

20

Small-scale

0.536

High

1047814

RUNX2
Runt-related transcription factor 2

1

10

Small-scale

0.536

High

1047840

ARMC8
Armadillo repeat-containing protein 8

1

7

High-throughput

0.536

High

1047857

FOXB1
Forkhead box protein B1

1

20

High-throughput

0.536

High

1047867

HES4
Transcription factor HES-4

1

20

High-throughput

0.536

High

1047863

HIPK2
Homeodomain-interacting protein kinase 2

1

17

Small-scale

0.527

High

158692

UTY
Histone demethylase UTY

1

19

Small-scale

0.527

High

333895

SIX3
Homeobox protein SIX3

1

20

Small-scale

0.527

High

446522

DPOLB
DNA polymerase beta

1

0

High-throughput

0.518

High

702423

PEX2
Peroxisome biogenesis factor 2

1

0

High-throughput

0.518

High

940482

DPOE2
DNA polymerase epsilon subunit 2

1

0

High-throughput

0.518

High

1040470

GSTM4
Glutathione S-transferase Mu 4

1

0

High-throughput

0.518

High

1047855

MPH6
M-phase phosphoprotein 6

1

0

High-throughput

0.518

High

1047835

GFI1B
Zinc finger protein Gfi-1b

1

6

Small-scale

0.515

High

705314

GRN
Progranulin

1

4

High-throughput

0.515

High

1047878

ATX10
Ataxin-10

1

2

High-throughput

0.515

High

1047887

RNF11
RING finger protein 11

1

6

High-throughput

0.515

High

788638

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

1032738

SATB1
DNA-binding protein SATB1

1

0

High-throughput

0.513

High

616303

RCC1
Regulator of chromosome condensation

1

5

High-throughput

0.508

High

627955

ANXA7
Annexin A7

1

4

High-throughput

0.508

High

808029

CDN1A
Cyclin-dependent kinase inhibitor 1

1

2

High-throughput

0.508

High

891476

GSK3B
Glycogen synthase kinase-3 beta

1

8

High-throughput

0.508

High

959319

RAP1B
Ras-related protein Rap-1b

1

6

High-throughput

0.508

High

994996

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.508

High

1047826

T22D1
TSC22 domain family protein 1

1

19

High-throughput

0.508

High

443321

CDK1
Cyclin-dependent kinase 1

1

4

Small-scale

0.501

High

481249

HMGB1
High mobility group protein B1

1

20

Small-scale

0.501

High

764684

CTNB1
Catenin beta-1

1

11

Small-scale

0.501

High

976887

ERR3
Estrogen-related receptor gamma

1

20

Small-scale

0.501

High

380420

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

2

High-throughput

0.494

High

962932

CH10
10 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.494

High

228235

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.486

High

939612

BID
BH3-interacting domain death agonist

1

0

High-throughput

0.486

High

1047801

B2CL1
Bcl-2-like protein 1

1

0

High-throughput

0.486

High

1047829

SMN
Survival motor neuron protein

1

0

High-throughput

0.486

High

62705

A4PIW0
Fusion protein SYT-SSX2

1

4

Small-scale

0.484

High

194552

KDM6A
Lysine-specific demethylase 6A

1

18

Small-scale

0.481

High

928265

ATN1
Atrophin-1

1

20

High-throughput

0.481

High

181500

TBXT
T-box transcription factor T

1

20

High-throughput

0.479

High

209989

CRX
Cone-rod homeobox protein

1

20

High-throughput

0.479

High

216931

KLF4
Krueppel-like factor 4

1

20

High-throughput

0.479

High

239941

SOX15
Transcription factor SOX-15

1

20

High-throughput

0.479

High

259832

BRD4
Bromodomain-containing protein 4

1

14

High-throughput

0.479

High

277091

PROP1
Homeobox protein prophet of Pit-1

1

20

Small-scale

0.479

High

370640

FOS
Protein c-Fos

1

12

High-throughput

0.479

High

395963

ESR1
Estrogen receptor

1

20

High-throughput

0.479

High

519966

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

538388

EGR2
E3 SUMO-protein ligase EGR2

1

7

High-throughput

0.479

High

540844

ERG
Transcriptional regulator ERG

1

19

High-throughput

0.479

High

581645

MYOD1
Myoblast determination protein 1

1

8

High-throughput

0.479

High

590407

GATA1
Erythroid transcription factor

1

20

High-throughput

0.479

High

662215

PAX7
Paired box protein Pax-7

1

20

High-throughput

0.479

High

662405

GATA2
Endothelial transcription factor GATA-2

1

20

High-throughput

0.479

High

662558

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

20

High-throughput

0.479

High

685162

PAX6
Paired box protein Pax-6

1

20

High-throughput

0.479

High

703123

TEAD1
Transcriptional enhancer factor TEF-1

1

3

High-throughput

0.479

High

775826

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.479

High

776057

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.479

High

776175

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

833920

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

837039

ELK3
ETS domain-containing protein Elk-3

1

20

High-throughput

0.479

High

846901

ETV4
ETS translocation variant 4

1

20

High-throughput

0.479

High

873075

SOX9
Transcription factor SOX-9

1

20

High-throughput

0.479

High

877510

LHX1
LIM/homeobox protein Lhx1

1

11

High-throughput

0.479

High

877771

TNNI2
Troponin I, fast skeletal muscle

1

3

High-throughput

0.479

High

885223

HXA1
Homeobox protein Hox-A1

1

18

High-throughput

0.479

High

895705

LHX2
LIM/homeobox protein Lhx2

1

12

High-throughput

0.479

High

942092

SOX10
Transcription factor SOX-10

1

20

High-throughput

0.479

High

942429

GSC
Homeobox protein goosecoid

1

20

High-throughput

0.479

High

944632

KLF3
Krueppel-like factor 3

1

18

High-throughput

0.479

High

1037783

IRF8
Interferon regulatory factor 8

1

3

High-throughput

0.479

High

1040040

PAX2
Paired box protein Pax-2

1

20

High-throughput

0.479

High

1045195

TF65
Transcription factor p65

1

7

Small-scale

0.479

High

1047800

PAX8
Paired box protein Pax-8

1

20

High-throughput

0.479

High

1047807

FOXI1
Forkhead box protein I1

1

20

High-throughput

0.479

High

1047808

FOXL1
Forkhead box protein L1

1

20

High-throughput

0.479

High

1047809

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

3

Small-scale

0.479

High

1047813

KLF5
Krueppel-like factor 5

1

19

High-throughput

0.479

High

1047821

EEA1
Early endosome antigen 1

1

20

High-throughput

0.479

High

1047823

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

1

3

High-throughput

0.479

High

1047824

IRF4
Interferon regulatory factor 4

1

3

High-throughput

0.479

High

1047825

SSXT
Protein SSXT

1

8

Small-scale

0.479

High

1047828

SSX2
Protein SSX2

1

2

Small-scale

0.479

High

1047830

TBR1
T-box brain protein 1

1

20

High-throughput

0.479

High

1047831

ISX
Intestine-specific homeobox

1

20

High-throughput

0.479

High

1047836

LHX8
LIM/homeobox protein Lhx8

1

11

High-throughput

0.479

High

1047845

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

1047846

SP7
Transcription factor Sp7

1

16

High-throughput

0.479

High

1047848

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

4

High-throughput

0.479

High

1047849

LHX4
LIM/homeobox protein Lhx4

1

12

High-throughput

0.479

High

1047856

FEV
Protein FEV

1

16

High-throughput

0.479

High

1047858

SOX7
Transcription factor SOX-7

1

20

High-throughput

0.479

High

1047861

FOXQ1
Forkhead box protein Q1

1

20

High-throughput

0.479

High

1047865

SOX17
Transcription factor SOX-17

1

20

High-throughput

0.479

High

1047868

GCM1
Chorion-specific transcription factor GCMa

1

2

High-throughput

0.479

High

1047870

SIX2
Homeobox protein SIX2

1

20

High-throughput

0.479

High

1047872

PLS4
Phospholipid scramblase 4

1

1

High-throughput

0.479

High

1047876

VSX1
Visual system homeobox 1

1

20

High-throughput

0.479

High

1047879

LHX3
LIM/homeobox protein Lhx3

1

12

High-throughput

0.479

High

1047883

ELF5
ETS-related transcription factor Elf-5

1

20

High-throughput

0.479

High

1047877

RERE
Arginine-glutamic acid dipeptide repeats protein

1

14

High-throughput

0.457

High

62699

A4PIV8
Fusion protein SYT-SSX1

1

4

Small-scale

0.445

High

188248

HDAC3
Histone deacetylase 3

1

20

Small-scale

0.445

High

553175

KCRB
Creatine kinase B-type

1

1

High-throughput

0.445

High

977120

YPEL5
Protein yippee-like 5

1

2

High-throughput

0.445

High

1047841

UN45B
Protein unc-45 homolog B

1

16

High-throughput

0.445

High

1047875

GID8
Glucose-induced degradation protein 8 homolog

1

3

High-throughput

0.445

High

1047851

APH1A
Gamma-secretase subunit APH-1A

1

2

High-throughput

0.439

High

974929

TYB4
Thymosin beta-4

1

0

High-throughput

0.438

High

1047873

ZF64B
Zinc finger protein 64

1

0

High-throughput

0.438

High

1047803

GOGA2
Golgin subfamily A member 2

1

20

High-throughput

0.437

High

1047804

FGL1
Fibrinogen-like protein 1

1

7

High-throughput

0.437

High

1047832

PRC2B
Protein PRRC2B

1

20

High-throughput

0.437

High

1047869

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

9

High-throughput

0.437

High

1047871

STAR7
StAR-related lipid transfer protein 7, mitochondrial

1

3

High-throughput

0.437

High

1047874

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

4

High-throughput

0.437

High

1047847

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

High-throughput

0.426

High

1047862

FXYD6
FXYD domain-containing ion transport regulator 6

1

0

High-throughput

0.282

High

1047881

CRCT1
Cysteine-rich C-terminal protein 1

1

0

High-throughput

0.282

High

1047885

PCDA4
Protocadherin alpha-4

1

0

High-throughput

0.282

High

1047853

IFT43
Intraflagellar transport protein 43 homolog

1

0

High-throughput

0.279

Low

458908

HEXB
Beta-hexosaminidase subunit beta

1

0

High-throughput

0.268

Low

1047838

K0408
Uncharacterized protein KIAA0408

1

0

High-throughput

0.265

Low

211679

LEU1
Leukemia-associated protein 1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025