HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: OTUB1 (Q96FW1)
Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1)
Gene: OTUB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.98	1.00	0.994

Property	Details
Experiments	25872870, 28190767, 29576527, 27182664, 33141564, 34049206, 34642328, 36114200, 38803224, 17550899, 22325355, 24071738, 23287719, 25527291, 25752577, 25723849, 26752685, 25590432, 27066941, 26876099 and 13 others more... 27256865, 32049508, 30718280, 35210618, 36822329, 24361330, 19211026, 20622874, 23562397, 23955022, 18954305, 23827681, 11689694
Identification Methods	pull down, proximity labelling technology, affinity chromatography technology, enzymatic study, x-ray crystallography, unspecified method
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Peptidase_C65~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0070062 - extracellular exosome
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 271
+	Hs
		476180 UBC_HUMAN (1-685): 0: 846: 100.00		OTUB2_HUMAN (47-270): 1.25e-104: 305: 47.77
+	Mm
		476861 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		OTUB1_MOUSE (1-271): 3.18e-150: 422: 99.63
+	Rn
		71344 UBC_RAT (1-108): 1.27e-29: 127: 90.74		OTUB1_RAT (1-271): 3.18e-150: 422: 99.63
+	Hs
		171499 UBD_HUMAN (155-304): 5.41e-28: 112: 32.05		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00
+	Hs
		475135 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00