HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: PSMD1 (Q99460)
26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112)
Gene: PSMD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.840

Property	Details
Experiments	24743594, 28190767, 33141564
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PC_rep~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 953
+	Hs
		475701 UBC_HUMAN (1-685): 0: 846: 100.00		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	At
		221381 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		PSD1A_ARATH (1-950): 0: 1219: 48.81
+	Sp
		251843 UBI4P_SCHPO (305-685): 1.76e-151: 445: 95.80		RPN2_SCHPO (1-953): 0: 1042: 43.67
+	At
		1092259 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		PSD1B_ARATH (1-950): 0: 1202: 48.70
+	Hs
		924124 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	Mm
		476785 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		PSMD1_MOUSE (1-953): 0: 1308: 99.06
+	Rn
		292216 UBC_RAT (1-108): 1.27e-29: 127: 90.74		PSMD1_RAT (1-953): 0: 1304: 98.64
+	Hs
		398072 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	Sc
		477186 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		RPN2_YEAST (2-953): 0: 984: 40.26
+	At
		1091720 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		PSD2B_ARATH (8-796): 0: 741: 17.37
+	At
		1092336 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		PSD2A_ARATH (8-796): 0: 738: 17.61
+	Hs
		923974 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Mm
		476933 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		PSMD2_MOUSE (8-796): 0: 800: 18.73
+	Hs
		397947 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Sc
		477264 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		RPN1_YEAST (8-604): 4.59e-149: 468: 15.96
+	Ce
		477558 UBIQ1_CAEEL (1-229): 5.97e-87: 292: 98.25		Q9GZH5_CAEEL (615-798): 1.13e-53: 204: 18.00