HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: ZRAN1 (Q9UGI0)
Ubiquitin thioesterase ZRANB1 (EC 3.4.19.12) (TRAF-binding domain-containing protein) (hTrabid) (Zinc finger Ran-binding domain-containing protein 1)
Gene: ZRANB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.983

Property	Details
Experiments	25752573, 25752577, 28190767, 19373254, 25527291, 35915203, 18281465, 20622874, 22157957, 23827681
Identification Methods	pull down, x-ray crystallography, enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, association, physical association, deubiquitination reaction

Property	Details
Interacting Pfam domains	OTU~ubiquitin, ubiquitin~zf-RanBP
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 708
+	Dr
		48762 F1QHN6_DANRE (229-685): 0: 555: 99.78		ZRN1B_DANRE (1-699): 0: 905: 77.45
+	Hs
		475915 UBC_HUMAN (1-685): 0: 846: 100.00		OTU7B_HUMAN (322-701): 2.32e-127: 400: 25.54
+	Hs
		476093 UBC_HUMAN (1-685): 0: 846: 100.00		OTU7A_HUMAN (322-701): 5.77e-122: 388: 26.33
+	Hs
		475332 UBC_HUMAN (1-685): 0: 846: 100.00		TNAP3_HUMAN (392-651): 2.48e-93: 308: 35.74
+	Hs
		924207 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		ZRAN1_HUMAN (1-697): 0: 987: 100.00
+	Hs
		476187 UBC_HUMAN (1-685): 0: 846: 100.00		RNF31_HUMAN (29-410): 7.77e-78: 271: 15.73
+	Mm
		476855 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		ZRAN1_MOUSE (1-697): 0: 989: 99.28
+	Hs
		275487 UBC_HUMAN (1-685): 0: 846: 100.00		CAN15_HUMAN (76-256): 3.1e-11: 69.2: 18.85
+	Dm
		1367032 Q9W418_DROME (229-685): 0: 557: 99.78		TRBID_DROME (2-140): 2.6e-16: 85: 28.48
+	Mm
		70741 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		OTU7B_MOUSE (322-701): 5.79e-124: 391: 25.78
+	Hs
		475060 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		OTU7B_HUMAN (322-701): 2.32e-127: 400: 25.54
+	Mm
		476820 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		TNAP3_MOUSE (392-651): 2.36e-92: 306: 36.10
+	Mm
		476959 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RNF31_MOUSE (8-410): 2.07e-87: 298: 14.99
+	Hs
		474920 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		TNAP3_HUMAN (392-651): 2.48e-93: 308: 35.74
+	Hs
		475133 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		RNF31_HUMAN (29-410): 7.77e-78: 271: 15.73
+	Mm
		477032 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		CAN15_MOUSE (76-256): 9.79e-12: 70.8: 19.15
+	Hs
		275486 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		CAN15_HUMAN (76-256): 3.1e-11: 69.2: 18.85