HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: ANC2 (Q9UJX6)
Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2)
Gene: ANAPC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	31350353
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ANAPC2~ubiquitin, Cullin~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 822
+	Hs
		475729 UBC_HUMAN (1-685): 0: 846: 100.00		CUL4A_HUMAN (244-806): 1.6e-151: 464: 16.42
+	Hs
		475730 UBC_HUMAN (1-685): 0: 846: 100.00		CUL4B_HUMAN (244-812): 1.06e-144: 451: 16.06
+	Hs
		475726 UBC_HUMAN (1-685): 0: 846: 100.00		CUL1_HUMAN (171-811): 5.04e-137: 426: 13.85
+	Hs
		475728 UBC_HUMAN (1-685): 0: 846: 100.00		CUL3_HUMAN (243-808): 2.97e-135: 421: 14.93
+	Hs
		475727 UBC_HUMAN (1-685): 0: 846: 100.00		CUL2_HUMAN (270-802): 8.7e-120: 381: 12.77
+	Sp
		142914 UBI4P_SCHPO (305-685): 1.76e-151: 445: 95.80		CUL1_SCHPO (158-806): 2.07e-111: 359: 13.06
+	At
		1091919 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		CUL1_ARATH (154-808): 3.92e-121: 384: 13.56
+	At
		1352191 RUB1_ARATH (457-609): 8.21e-49: 169: 78.43		CUL3A_ARATH (242-808): 3e-156: 475: 15.33
+	At
		1321116 RUB1_ARATH (457-609): 8.21e-49: 169: 78.43		CUL3B_ARATH (242-808): 7.45e-149: 456: 15.64
+	Hs
		923984 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		CUL4A_HUMAN (244-806): 1.6e-151: 464: 16.42
+	Hs
		923985 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		CUL4B_HUMAN (244-812): 1.06e-144: 451: 16.06
+	Rn
		71349 UBC_RAT (1-108): 1.27e-29: 127: 90.74		B2RYJ3_RAT (244-804): 2.53e-151: 463: 16.98
+	Hs
		923983 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		CUL3_HUMAN (243-808): 2.97e-135: 421: 14.93
+	Hs
		475024 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		CUL4B_HUMAN (244-812): 1.06e-144: 451: 16.06
+	At
		1277343 RUB1_ARATH (457-609): 8.21e-49: 169: 78.43		CUL1_ARATH (154-808): 3.92e-121: 384: 13.56
+	Rn
		70071 UBC_RAT (1-108): 1.27e-29: 127: 90.74		B1WBY1_RAT (171-811): 4.78e-137: 426: 13.85
+	At
		1247030 RUB2_ARATH (457-608): 1.43e-47: 166: 78.29		CUL1_ARATH (154-808): 3.92e-121: 384: 13.56
+	Rn
		78188 UBC_RAT (1-108): 1.27e-29: 127: 90.74		CUL3_RAT (243-808): 2.62e-135: 422: 14.93
+	Mm
		477034 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		CUL3_MOUSE (243-808): 4e-135: 421: 14.93
+	Mm
		477001 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		CUL2_MOUSE (169-802): 2.12e-123: 390: 11.53