HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: CBLC (Q9ULV8)
E3 ubiquitin-protein ligase CBL-C (EC 2.3.2.27) (RING finger protein 57) (RING-type E3 ubiquitin transferase CBL-C) (SH3-binding protein CBL-3) (SH3-binding protein CBL-C) (Signal transduction protein CBL-C)
Gene: CBLC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	14661060
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Cbl_N3~ubiquitin, ubiquitin~zf-C3HC4_3
Common GO terms	GO:0005886 - plasma membrane GO:0016567 - protein ubiquitination
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 474
+	Hs
		475700 UBC_HUMAN (1-685): 0: 846: 100.00		CBLB_HUMAN (4-471): 0: 704: 41.18
+	Hs
		475339 UBC_HUMAN (1-685): 0: 846: 100.00		CBL_HUMAN (11-473): 0: 695: 42.14
+	Hs
		476198 UBC_HUMAN (1-685): 0: 846: 100.00		RN185_HUMAN (344-450): 1.35e-30: 119: 28.44
+	Hs
		476274 UBC_HUMAN (1-685): 0: 846: 100.00		RNF5_HUMAN (345-450): 3.86e-29: 114: 21.30
+	Hs
		475759 UBC_HUMAN (1-685): 0: 846: 100.00		HLTF_HUMAN (326-403): 7.6e-19: 91.8: 22.50
+	Xl
		1140135 Q7SY79_XENLA (77-685): 0: 744: 99.84		Q5XGX4_XENLA (343-450): 5.67e-31: 119: 28.18
+	Hs
		610336 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		CBL_HUMAN (11-473): 0: 695: 42.14
+	Mm
		476784 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		CBLB_MOUSE (4-471): 0: 707: 41.18
+	Rn
		88778 UBC_RAT (1-108): 1.27e-29: 127: 90.74		D3ZV15_RAT (13-473): 0: 688: 43.73
+	Dm
		1215068 Q9W418_DROME (229-685): 0: 557: 99.78		Q8IR26_DROME (329-449): 4.25e-29: 117: 22.76
+	Dm
		1215070 R9PY16_DROME (457-685): 5.07e-80: 258: 90.39		Q8IR26_DROME (329-449): 4.25e-29: 117: 22.76
+	Dm
		1375478 R9PY16_DROME (457-685): 5.07e-80: 258: 90.39		Q9VXP1_DROME (329-449): 4.43e-29: 117: 22.76
+	Xl
		1140130 Q6GMC1_XENLA (609-684): 7.23e-41: 148: 100.00		Q5XGX4_XENLA (343-450): 5.67e-31: 119: 28.18
+	Hs
		924117 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		RN185_HUMAN (344-450): 1.35e-30: 119: 28.44
+	Mm
		476948 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RN185_MOUSE (344-450): 1.78e-31: 121: 28.44
+	Hs
		475137 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		RN185_HUMAN (344-450): 1.35e-30: 119: 28.44