HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.710

Property	Details
Experiments	24039852
Identification Methods	pull down, x-ray crystallography
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	SH3_1~ubiquitin, SH3_9~ubiquitin
Common GO terms	GO:0005886 - plasma membrane GO:0031982 - vesicle GO:0070062 - extracellular exosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 639
+	Hs
		476167 UBC_HUMAN (1-685): 0: 846: 100.00		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		208981 UBC_HUMAN (1-685): 0: 846: 100.00		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Hs
		475592 UBC_HUMAN (1-685): 0: 846: 100.00		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		476095 UBC_HUMAN (1-685): 0: 846: 100.00		SH3R3_HUMAN (5-625): 1.58e-17: 88.8: 13.36
+	Hs
		475936 UBC_HUMAN (1-685): 0: 846: 100.00		DNMBP_HUMAN (113-602): 4.85e-17: 87.7: 15.23
+	Hs
		476483 UBC_HUMAN (1-685): 0: 846: 100.00		ITSN2_HUMAN (1-63): 2.7e-12: 72.2: 34.92
+	Hs
		475816 UBC_HUMAN (1-685): 0: 846: 100.00		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64
+	Hs
		923946 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Rn
		924996 UBC_RAT (1-108): 1.27e-29: 127: 90.74		GRB2_RAT (112-328): 1.9e-40: 148: 18.27
+	Hs
		474986 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		557653 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Mm
		70590 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		B2RR82_MOUSE (1-63): 6.9e-12: 71.1: 34.92
+	Mm
		477062 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		ITSN1_MOUSE (1-55): 4.64e-10: 65.3: 41.82