HitPredict

Interactor 1: UBA6 (A0AVT1)
Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2)
Gene: UBA6

Interactor 2: UB2G2 (P60604)
Ubiquitin-conjugating enzyme E2 G2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G2) (Ubiquitin carrier protein G2) (Ubiquitin-protein ligase G2)
Gene: UBE2G2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	17597759
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1052 Hs			1 165
+	Hs
		48104 UBA6_HUMAN (1-1052): 0: 1156: 100.00		UB2D1_HUMAN (4-164): 3.3e-73: 217: 36.03
+	Hs
		48107 UBA6_HUMAN (1-1052): 0: 1156: 100.00		UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03
+	Hs
		48106 UBA6_HUMAN (1-1052): 0: 1156: 100.00		UB2D3_HUMAN (4-164): 1.16e-71: 213: 34.78
+	Hs
		607190 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D4_HUMAN (4-164): 2.75e-74: 220: 36.03
+	Hs
		607026 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D1_HUMAN (4-164): 3.3e-73: 217: 36.03
+	Hs
		607050 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03
+	Hs
		607039 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D3_HUMAN (4-164): 1.16e-71: 213: 34.78
+	Hs
		607038 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2G2_HUMAN (1-165): 5.88e-71: 212: 100.00
+	Hs
		607054 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UBE2B_HUMAN (1-162): 5.98e-71: 212: 38.89
+	Hs
		607046 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2G1_HUMAN (4-164): 2.51e-69: 208: 50.00
+	Hs
		607023 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UBE2A_HUMAN (1-162): 1.72e-67: 203: 38.89
+	Oc
		1100193 UBA1_RABIT (1-1045): 0: 1139: 41.11		UB2R2_RABIT (4-158): 9.21e-45: 149: 50.00
+	Hs
		607099 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2R2_HUMAN (4-158): 9.21e-45: 149: 50.00
+	Hs
		607022 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2R1_HUMAN (4-159): 1.54e-43: 145: 49.08
+	Sp
		293848 UBA1_SCHPO (26-1043): 0: 995: 40.25		UBC4_SCHPO (4-163): 5.27e-71: 212: 34.38
+	Sp
		116506 UBA1_SCHPO (26-1043): 0: 995: 40.25		UBC7_SCHPO (1-165): 4.56e-70: 210: 66.87
+	Sp
		293852 UBA1_SCHPO (26-1043): 0: 995: 40.25		UBC15_SCHPO (9-151): 3.2e-55: 173: 56.64
+	Sp
		293847 UBA1_SCHPO (26-1043): 0: 995: 40.25		UBC2_SCHPO (1-162): 3.8e-36: 124: 37.65
+	Sc
		539443 UBA1_YEAST (24-1046): 0: 979: 40.52		UBC3_YEAST (4-162): 3.31e-37: 130: 44.79
+	Sc
		410211 UBA1_YEAST (24-1046): 0: 979: 40.52		UBC2_YEAST (1-162): 1.08e-33: 118: 37.65