HitPredict

Interactor 1: GRAB (P10144)
Granzyme B (EC 3.4.21.79) (C11) (CTLA-1) (Cathepsin G-like 1) (CTSGL1) (Cytotoxic T-lymphocyte proteinase 2) (Lymphocyte protease) (Fragmentin-2) (Granzyme-2) (Human lymphocyte protein) (HLP) (SECT) (T-cell serine protease 1-3E)
Gene: GZMB

Interactor 2: TBA1A (Q71U36)
Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain]
Gene: TUBA1A

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	17283187, 16495481
Identification Methods	enzymatic study, protease assay
Interaction Type	direct interaction, protein cleavage

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 247 Hs			1 451
+	Hs
		714751 TRY3_HUMAN (8-245): 1.09e-107: 314: 34.86		TBA1B_HUMAN (1-440): 0: 715: 99.55
+	Hs
		595562 GRAH_HUMAN (1-246): 3.12e-98: 288: 71.55		TBA1C_HUMAN (1-451): 0: 726: 98.00
+	Hs
		1309527 KLK11_HUMAN (15-245): 6.75e-95: 281: 36.82		TBA1C_HUMAN (1-451): 0: 726: 98.00
+	Hs
		595527 GRAH_HUMAN (1-246): 3.12e-98: 288: 71.55		TBA4A_HUMAN (1-450): 0: 717: 96.00
+	Hs
		589996 TRYB2_HUMAN (21-241): 5.01e-94: 278: 30.86		TBA1C_HUMAN (1-451): 0: 726: 98.00
+	Hs
		439340 CATG_HUMAN (1-247): 4.54e-99: 290: 57.09		TBA1A_HUMAN (1-440): 0: 713: 100.00
+	Hs
		933554 KLK6_HUMAN (1-245): 6.02e-97: 285: 33.33		TBA4A_HUMAN (1-450): 0: 717: 96.00
+	Hs
		595544 GRAH_HUMAN (1-246): 3.12e-98: 288: 71.55		TBA1A_HUMAN (1-440): 0: 713: 100.00
+	Hs
		1309491 KLK15_HUMAN (14-246): 3.6e-92: 273: 33.20		TBA1C_HUMAN (1-451): 0: 726: 98.00
+	Hs
		933653 KLK11_HUMAN (15-245): 6.75e-95: 281: 36.82		TBA4A_HUMAN (1-450): 0: 717: 96.00
+	Hs
		933221 PRSS8_HUMAN (13-244): 6.64e-94: 280: 29.76		TBA1B_HUMAN (1-440): 0: 715: 99.55
+	Hs
		1175223 KLK11_HUMAN (15-245): 6.75e-95: 281: 36.82		TBA1A_HUMAN (1-440): 0: 713: 100.00
+	Hs
		589995 TRYB2_HUMAN (21-241): 5.01e-94: 278: 30.86		TBA1A_HUMAN (1-440): 0: 713: 100.00
+	Hs
		933613 KLK15_HUMAN (14-246): 3.6e-92: 273: 33.20		TBA4A_HUMAN (1-450): 0: 717: 96.00
+	Hs
		1175174 KLK15_HUMAN (14-246): 3.6e-92: 273: 33.20		TBA1A_HUMAN (1-440): 0: 713: 100.00
+	Hs
		427973 CATG_HUMAN (1-247): 4.54e-99: 290: 57.09		TBB5_HUMAN (1-439): 0: 695: 40.77
+	Hs
		428017 GRAH_HUMAN (1-246): 3.12e-98: 288: 71.55		TBB5_HUMAN (1-439): 0: 695: 40.77
+	Hs
		428014 TRYB2_HUMAN (21-241): 5.01e-94: 278: 30.86		TBB5_HUMAN (1-439): 0: 695: 40.77
+	Hs
		589991 TRYB2_HUMAN (21-241): 5.01e-94: 278: 30.86		TBB4B_HUMAN (1-437): 0: 693: 40.50
+	Mm
		371482 CFAD_MOUSE (5-241): 2.87e-44: 151: 33.33		TBA1B_MOUSE (1-440): 0: 715: 99.55