Protein: HCFC2
Host cell factor 2 (HCF-2) (C2 factor)

Gene: HCFC2
Organism: Homo sapiens
Interactions: 94
UniProt ID: Q9Y5Z7

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1458479

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

9

7

Small-scale

0.751

High

965377

WDR5
WD repeat-containing protein 5

7

4

Small-scale

0.746

High

1145571

RBBP5
Retinoblastoma-binding protein 5

7

8

Small-scale

0.741

High

1364746

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

5

5

Small-scale

0.712

High

1041631

KMT2A
Histone-lysine N-methyltransferase 2A

4

20

Small-scale

0.702

High

230476

CREB3
Cyclic AMP-responsive element-binding protein 3

4

3

High-throughput

0.691

High

905522

HCFC1
Host cell factor 1

4

17

Small-scale

0.691

High

571645

IRF2
Interferon regulatory factor 2

3

4

High-throughput

0.675

High

129602

MEN1
Menin

4

1

Small-scale

0.672

High

175957

SET1A
Histone-lysine N-methyltransferase SETD1A

3

20

High-throughput

0.667

High

1308622

NUDC3
NudC domain-containing protein 3

3

14

High-throughput

0.667

High

1338720

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

3

13

High-throughput

0.667

High

1430670

THAP2
THAP domain-containing protein 2

3

9

High-throughput

0.667

High

1454065

CXXC1
CXXC-type zinc finger protein 1

3

13

High-throughput

0.667

High

1462042

KMT2B
Histone-lysine N-methyltransferase 2B

3

20

High-throughput

0.667

High

1454744

KANL3
KAT8 regulatory NSL complex subunit 3

3

1

High-throughput

0.650

High

1023925

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

3

3

High-throughput

0.643

High

186149

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

2

5

High-throughput

0.628

High

538182

HSP7C
Heat shock cognate 71 kDa protein

2

4

High-throughput

0.628

High

610961

TCPA
T-complex protein 1 subunit alpha

2

7

High-throughput

0.628

High

821640

TCPZ
T-complex protein 1 subunit zeta

2

10

High-throughput

0.628

High

876242

TCPE
T-complex protein 1 subunit epsilon

2

9

High-throughput

0.628

High

882238

TCPG
T-complex protein 1 subunit gamma

2

8

High-throughput

0.628

High

899646

TCPD
T-complex protein 1 subunit delta

2

8

High-throughput

0.628

High

1007360

TCPB
T-complex protein 1 subunit beta

2

9

High-throughput

0.628

High

1363726

TCPW
T-complex protein 1 subunit zeta-2

2

11

High-throughput

0.628

High

1407652

TCPH
T-complex protein 1 subunit eta

2

9

High-throughput

0.628

High

1413336

DIDO1
Death-inducer obliterator 1

2

15

High-throughput

0.628

High

997215

TBA4A
Tubulin alpha-4A chain

2

0

High-throughput

0.602

High

1192020

TBB8
Tubulin beta-8 chain

2

0

High-throughput

0.602

High

1491373

NF2L3
Nuclear factor erythroid 2-related factor 3

2

6

High-throughput

0.601

High

397333

ESR1
Estrogen receptor

2

8

High-throughput

0.571

High

1367701

ESR2
Estrogen receptor beta

2

8

High-throughput

0.571

High

1307824

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

2

Small-scale

0.561

High

841095

HELZ
Probable helicase with zinc finger domain

2

2

High-throughput

0.552

High

899298

TCPQ
T-complex protein 1 subunit theta

1

8

High-throughput

0.536

High

995373

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.536

High

1028147

IRF9
Interferon regulatory factor 9

1

4

High-throughput

0.536

High

1092953

STRN3
Striatin-3

1

9

High-throughput

0.536

High

1152399

ZN174
Zinc finger protein 174

1

2

High-throughput

0.536

High

1163318

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.536

High

1228224

CR3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3

1

4

High-throughput

0.536

High

1328574

NGEF
Ephexin-1

1

6

High-throughput

0.536

High

1371219

GLMN
Glomulin

1

3

High-throughput

0.536

High

1397728

ZN597
Zinc finger protein 597

1

2

High-throughput

0.536

High

1453294

UBIP1
Upstream-binding protein 1

1

1

High-throughput

0.536

High

1491002

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

3

High-throughput

0.536

High

1234718

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

1

0

High-throughput

0.513

High

1413548

RAMAC
RNA guanine-N7 methyltransferase activating subunit

1

0

High-throughput

0.513

High

1356149

THAP3
THAP domain-containing protein 3

1

9

High-throughput

0.489

High

1372434

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

1

High-throughput

0.489

High

1087640

GRSF1
G-rich sequence factor 1

1

4

Small-scale

0.481

High

71488

P20L1
PHD finger protein 20-like protein 1

1

5

High-throughput

0.479

High

161529

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

194634

KDM6A
Lysine-specific demethylase 6A

1

6

High-throughput

0.479

High

219760

FOXO3
Forkhead box protein O3

1

6

Small-scale

0.479

High

224404

BUB3
Mitotic checkpoint protein BUB3

1

7

High-throughput

0.479

High

283160

PSIP1
PC4 and SFRS1-interacting protein

1

1

High-throughput

0.479

High

284906

TADA3
Transcriptional adapter 3

1

1

High-throughput

0.479

High

675741

TYY1
Transcriptional repressor protein YY1

1

2

High-throughput

0.479

High

739050

ELF1
ETS-related transcription factor Elf-1

1

5

High-throughput

0.479

High

783462

TRI23
E3 ubiquitin-protein ligase TRIM23

1

1

High-throughput

0.479

High

913825

ZN131
Zinc finger protein 131

1

2

High-throughput

0.479

High

928374

ATN1
Atrophin-1

1

13

High-throughput

0.479

High

980624

H4
Histone H4

1

3

High-throughput

0.479

High

1130614

NCOA6
Nuclear receptor coactivator 6

1

6

High-throughput

0.479

High

1152770

ELF2
ETS-related transcription factor Elf-2

1

5

High-throughput

0.479

High

1250062

WDR82
WD repeat-containing protein 82

1

12

High-throughput

0.479

High

1257188

PAXI1
PAX-interacting protein 1

1

6

High-throughput

0.479

High

1276125

KANL1
KAT8 regulatory NSL complex subunit 1

1

1

High-throughput

0.479

High

1315083

ZZZ3
ZZ-type zinc finger-containing protein 3

1

3

High-throughput

0.479

High

1338287

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.479

High

1339075

NUP43
Nucleoporin Nup43

1

11

High-throughput

0.479

High

1388786

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

4

Small-scale

0.479

High

1390200

MCRS1
Microspherule protein 1

1

1

High-throughput

0.479

High

1415303

PHF20
PHD finger protein 20

1

12

High-throughput

0.479

High

1420489

DPY30
Protein dpy-30 homolog

1

1

High-throughput

0.479

High

1435972

KAT8
Histone acetyltransferase KAT8

1

1

High-throughput

0.479

High

1436250

CSR2B
Cysteine-rich protein 2-binding protein

1

5

High-throughput

0.479

High

1437171

KANL2
KAT8 regulatory NSL complex subunit 2

1

1

High-throughput

0.479

High

1449173

MBIP1
MAP3K12-binding inhibitory protein 1

1

2

High-throughput

0.479

High

1454813

RERE
Arginine-glutamic acid dipeptide repeats protein

1

9

High-throughput

0.479

High

1461538

ZN608
Zinc finger protein 608

1

3

High-throughput

0.479

High

1461650

YETS2
YEATS domain-containing protein 2

1

10

High-throughput

0.479

High

1462559

SET1B
Histone-lysine N-methyltransferase SETD1B

1

20

High-throughput

0.479

High

1490540

NUDC
Nuclear migration protein nudC

1

14

High-throughput

0.479

High

612338

ARF4
ADP-ribosylation factor 4

1

0

High-throughput

0.458

High

1352874

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1460499

CNOT7
CCR4-NOT transcription complex subunit 7

1

0

High-throughput

0.458

High

373634

MYC
Myc proto-oncogene protein

1

9

High-throughput

0.445

High

1393270

SENP5
Sentrin-specific protease 5

1

2

High-throughput

0.445

High

1413144

THAP7
THAP domain-containing protein 7

1

9

High-throughput

0.445

High

571545

GLU2B
Glucosidase 2 subunit beta

1

0

High-throughput

0.279

Low

1366106

K0232
Uncharacterized protein KIAA0232

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025