HitPredict

Interactor 1: IL8 (P10145)
Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (Emoctakin) (Granulocyte chemotactic protein 1) (GCP-1) (Monocyte-derived neutrophil chemotactic factor) (MDNCF) (Monocyte-derived neutrophil-activating peptide) (MONAP) (Neutrophil-activating protein 1) (NAP-1) (Protein 3-10C) (T-cell chemotactic factor) [Cleaved into: MDNCF-a (GCP/IL-8 protein IV) (IL8/NAP1 form I); Interleukin-8 ((Ala-IL-8)77) (GCP/IL-8 protein II) (IL-8(1-77)) (IL8/NAP1 form II) (MDNCF-b); IL-8(5-77); IL-8(6-77) ((Ser-IL-8)72) (GCP/IL-8 protein I) (IL8/NAP1 form III) (Lymphocyte-derived neutrophil-activating factor) (LYNAP) (MDNCF-c) (Neutrophil-activating factor) (NAF); IL-8(7-77) (GCP/IL-8 protein V) (IL8/NAP1 form IV); IL-8(8-77) (GCP/IL-8 protein VI) (IL8/NAP1 form V); IL-8(9-77) (GCP/IL-8 protein III) (IL8/NAP1 form VI)]
Gene: CXCL8

Interactor 2: CXCR1 (P25024)
C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181)
Gene: CXCR1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.978

Property	Details
Experiments	10368283, 8550564, 9553055, 10206993, 9725262, 9195914, 8245475, 12628493, 8662882, 1840701, 8702798, 9485196
Identification Methods	x-ray crystallography, biochemical, affinity chromatography technology, competition binding, saturation binding, nuclear magnetic resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0007186 - G protein-coupled receptor signaling pathway GO:0019722 - calcium-mediated signaling GO:0030593 - neutrophil chemotaxis GO:0031623 - receptor internalization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 99 Hs			1 350
+	Mm
		291525 CXCL9_MOUSE (4-91): 4.77e-25: 92.5: 32.58		CXCR3_MOUSE (1-335): 2.34e-77: 243: 37.39
+	Hs
		217751 CXL13_HUMAN (23-99): 3.53e-25: 92.5: 31.17		CXCR3_HUMAN (1-349): 6.16e-77: 242: 37.61
+	Mm
		291524 CXL10_MOUSE (1-95): 2.97e-24: 89.8: 22.92		CXCR3_MOUSE (1-335): 2.34e-77: 243: 37.39
+	Hs
		364107 CXL10_HUMAN (3-94): 5.69e-22: 84: 21.51		CCR3_HUMAN (33-346): 2.05e-79: 248: 31.56
+	Hs
		625736 CXCL5_HUMAN (14-96): 2.17e-26: 95.5: 31.33		CXCR1_HUMAN (1-340): 2.74e-73: 232: 100.00
+	Hs
		364105 CXL10_HUMAN (3-94): 5.69e-22: 84: 21.51		CXCR3_HUMAN (1-349): 6.16e-77: 242: 37.61
+	Mm
		500672 CXCL2_MOUSE (16-99): 7.01e-26: 94: 40.48		CXCR2_MOUSE (3-339): 5.77e-73: 232: 69.23
+	Hs
		364041 CXCL7_HUMAN (28-99): 1.43e-24: 91.3: 45.83		CXCR1_HUMAN (1-340): 2.74e-73: 232: 100.00
+	Hs
		448987 GROA_HUMAN (27-99): 1.72e-24: 90.5: 42.47		CXCR1_HUMAN (1-340): 2.74e-73: 232: 100.00
+	Hs
		625737 CXCL6_HUMAN (21-96): 3.83e-24: 89.8: 30.26		CXCR1_HUMAN (1-340): 2.74e-73: 232: 100.00
+	Mm
		522397 GROA_MOUSE (26-95): 1.26e-23: 87.8: 50.00		CXCR2_MOUSE (3-339): 5.77e-73: 232: 69.23
+	Hs
		486185 IL8_HUMAN (1-99): 1.26e-30: 105: 100.00		CXCR2_HUMAN (1-349): 3.91e-65: 212: 75.07
+	Hs
		217747 CXL13_HUMAN (23-99): 3.53e-25: 92.5: 31.17		CXCR5_HUMAN (12-349): 1.84e-67: 218: 33.24
+	Hs
		625748 CXCL5_HUMAN (14-96): 2.17e-26: 95.5: 31.33		CXCR2_HUMAN (1-349): 3.91e-65: 212: 75.07
+	Hs
		217753 CXL13_HUMAN (23-99): 3.53e-25: 92.5: 31.17		ACKR4_HUMAN (3-349): 7.98e-66: 213: 28.82
+	Hs
		364042 CXCL7_HUMAN (28-99): 1.43e-24: 91.3: 45.83		CXCR2_HUMAN (1-349): 3.91e-65: 212: 75.07
+	Hs
		448988 GROA_HUMAN (27-99): 1.72e-24: 90.5: 42.47		CXCR2_HUMAN (1-349): 3.91e-65: 212: 75.07
+	Hs
		587767 CXCL2_HUMAN (23-99): 1.44e-24: 90.5: 40.26		CXCR2_HUMAN (1-349): 3.91e-65: 212: 75.07
+	Hs
		625758 CXCL6_HUMAN (21-96): 3.83e-24: 89.8: 30.26		CXCR2_HUMAN (1-349): 3.91e-65: 212: 75.07
+	Hs
		587786 CXCL3_HUMAN (30-99): 7.58e-24: 89: 41.43		CXCR2_HUMAN (1-349): 3.91e-65: 212: 75.07