HitPredict

Interactor 1: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Interactor 2: P55G (Q92569)
Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK)
Gene: PIK3R3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0010628 - positive regulation of gene expression
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 920 Hs			1 461
+	Hs
		337320 ANDR_HUMAN (1-920): 0: 966: 100.00		ABL1_HUMAN (3-461): 1.02e-93: 308: 16.12
+	Hs
		487153 ANDR_HUMAN (1-920): 0: 966: 100.00		P85A_HUMAN (48-455): 9.1e-92: 295: 79.17
+	Hs
		129177 ANDR_HUMAN (1-920): 0: 966: 100.00		P85B_HUMAN (56-453): 2.19e-87: 283: 74.12
+	Hs
		487203 ANDR_HUMAN (1-920): 0: 966: 100.00		ABL2_HUMAN (324-459): 5.26e-21: 98.5: 25.36
+	Hs
		411564 ANDR_HUMAN (1-920): 0: 966: 100.00		LCK_HUMAN (309-458): 5.54e-21: 97.3: 25.95
+	Hs
		442764 ANDR_HUMAN (1-920): 0: 966: 100.00		HCK_HUMAN (310-458): 1.43e-19: 93.1: 26.75
+	Hs
		433225 ANDR_HUMAN (1-920): 0: 966: 100.00		YES_HUMAN (317-459): 6.84e-19: 91.2: 23.72
+	Hs
		487088 ANDR_HUMAN (1-920): 0: 966: 100.00		SRC_HUMAN (323-459): 8.26e-19: 90.8: 24.14
+	Hs
		454790 ANDR_HUMAN (1-920): 0: 966: 100.00		FGR_HUMAN (323-459): 2.54e-18: 89.2: 26.21
+	Hs
		487245 ANDR_HUMAN (1-920): 0: 966: 100.00		BLK_HUMAN (285-458): 2.65e-18: 89.2: 23.50
+	Hs
		433537 ANDR_HUMAN (1-920): 0: 966: 100.00		LYN_HUMAN (298-458): 6.17e-18: 88.1: 24.85
+	Hs
		147479 ANDR_HUMAN (1-920): 0: 966: 100.00		SOCS6_HUMAN (47-165): 1.85e-17: 86.8: 31.06
+	Hs
		487829 ANDR_HUMAN (1-920): 0: 966: 100.00		VAV3_HUMAN (44-159): 6.81e-16: 82.5: 30.17
+	Hs
		487256 ANDR_HUMAN (1-920): 0: 966: 100.00		VAV2_HUMAN (38-159): 4.46e-13: 73.7: 22.95
+	Hs
		487202 ANDR_HUMAN (1-920): 0: 966: 100.00		MATK_HUMAN (341-456): 1.11e-12: 71.8: 22.22
+	Hs
		487102 ANDR_HUMAN (1-920): 0: 966: 100.00		VAV_HUMAN (65-170): 4e-12: 70.6: 27.36
+	Hs
		487621 ANDR_HUMAN (1-920): 0: 966: 100.00		SHC3_HUMAN (43-164): 3.62e-12: 70.2: 31.15
+	Hs
		487107 ANDR_HUMAN (1-920): 0: 966: 100.00		PLCG2_HUMAN (337-452): 6.98e-12: 69.8: 33.33
+	Hs
		129156 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		P85B_HUMAN (56-453): 2.19e-87: 283: 74.12
+	Hs
		368834 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		YES_HUMAN (317-459): 6.84e-19: 91.2: 23.72