Protein: EGLN1
Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20)

Gene: EGLN1
Organism: Homo sapiens
Interactions: 84
UniProt ID: Q9GZT9

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006879 - intracellular iron ion homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1085668

HIF1A
Hypoxia-inducible factor 1-alpha

28

14

Small-scale

0.991

High

1306535

EPAS1
Endothelial PAS domain-containing protein 1

7

14

Small-scale

0.959

High

1053172

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

10

5

Small-scale

0.756

High

1326655

EGLN3
Prolyl hydroxylase EGLN3

2

4

Small-scale

0.754

High

438509

HS90B
Heat shock protein HSP 90-beta

4

1

Small-scale

0.692

High

1069501

TEBP
Prostaglandin E synthase 3

5

0

Small-scale

0.684

High

1310626

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

3

1

High-throughput

0.667

High

432244

HS90A
Heat shock protein HSP 90-alpha

2

1

Small-scale

0.624

High

772153

VHL
von Hippel-Lindau disease tumor suppressor

2

1

Small-scale

0.624

High

254004

MTG16
Protein CBFA2T3

1

1

Small-scale

0.618

High

987468

MTG8
Protein CBFA2T1

1

2

Small-scale

0.618

High

1326653

EGLN1
Egl nine homolog 1

1

4

Small-scale

0.618

High

1034991

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

5

Small-scale

0.611

High

1326663

ING4
Inhibitor of growth protein 4

2

0

Small-scale

0.605

High

1261322

EFMT1
EEF1A lysine methyltransferase 1

2

0

High-throughput

0.602

High

199143

SIAH2
E3 ubiquitin-protein ligase SIAH2

2

3

Small-scale

0.584

High

649156

ARNT
Aryl hydrocarbon receptor nuclear translocator

2

14

Small-scale

0.584

High

1042495

CUL3
Cullin-3

2

1

Small-scale

0.584

High

1251826

OSR1
Protein odd-skipped-related 1

2

1

Small-scale

0.584

High

1326660

LIMD1
LIM domain-containing protein 1

2

11

Small-scale

0.584

High

523141

SRC
Proto-oncogene tyrosine-protein kinase Src

1

1

Small-scale

0.578

High

796346

MAGAB
Melanoma-associated antigen 11

1

6

Small-scale

0.573

High

1285185

SH3K1
SH3 domain-containing kinase-binding protein 1

1

1

Small-scale

0.573

High

1034532

OS9
Protein OS-9

2

1

Small-scale

0.565

High

1033005

PLD1
Phospholipase D1

1

1

Small-scale

0.561

High

1326664

ZN281
Zinc finger protein 281

1

1

High-throughput

0.541

High

1307474

CITE1
Cbp/p300-interacting transactivator 1

1

1

High-throughput

0.536

High

935219

H31
Histone H3.1

1

0

Small-scale

0.527

High

350529

RASK
GTPase KRas

1

0

High-throughput

0.518

High

538025

KPYM
Pyruvate kinase PKM

1

1

Small-scale

0.515

High

591092

BTF3
Transcription factor BTF3

1

0

High-throughput

0.513

High

1326656

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

0

High-throughput

0.513

High

133012

SDCB1
Syntenin-1

1

3

Small-scale

0.501

High

151178

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

4

High-throughput

0.479

High

159401

PLD2
Phospholipase D2

1

1

Small-scale

0.479

High

195841

TET3
Methylcytosine dioxygenase TET3

1

3

Small-scale

0.479

High

208193

SPY2
Protein sprouty homolog 2

1

2

Small-scale

0.479

High

214368

SPOP
Speckle-type POZ protein

1

3

High-throughput

0.479

High

244912

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

301233

RHBT3
Rho-related BTB domain-containing protein 3

1

6

Small-scale

0.479

High

323109

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

338953

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

383967

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

2

High-throughput

0.479

High

411846

LCK
Tyrosine-protein kinase Lck

1

1

High-throughput

0.479

High

435753

IGF1R
Insulin-like growth factor 1 receptor

1

3

High-throughput

0.479

High

547207

EZRI
Ezrin

1

1

High-throughput

0.479

High

583573

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.479

High

625027

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

3

Small-scale

0.479

High

682020

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

Small-scale

0.479

High

682205

AKT2
RAC-beta serine/threonine-protein kinase

1

2

Small-scale

0.479

High

729351

VGFR3
Vascular endothelial growth factor receptor 3

1

2

High-throughput

0.479

High

796174

MAGA9
Melanoma-associated antigen 9

1

6

Small-scale

0.479

High

808904

YAP1
Transcriptional coactivator YAP1

1

1

Small-scale

0.479

High

933600

TBA4A
Tubulin alpha-4A chain

1

4

High-throughput

0.479

High

972583

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

5

Small-scale

0.479

High

1045142

RUNX3
Runt-related transcription factor 3

1

1

Small-scale

0.479

High

1049323

KEAP1
Kelch-like ECH-associated protein 1

1

1

Small-scale

0.479

High

1154486

TET2
Methylcytosine dioxygenase TET2

1

3

Small-scale

0.479

High

1216296

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

1

High-throughput

0.479

High

1260091

IASPP
RelA-associated inhibitor

1

6

Small-scale

0.479

High

1268908

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

1303153

RMD3
Regulator of microtubule dynamics protein 3

1

1

High-throughput

0.479

High

1326654

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

1326657

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

Small-scale

0.479

High

1326659

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1326661

TBK1
Serine/threonine-protein kinase TBK1

1

6

Small-scale

0.479

High

305088

SPN1
Snurportin-1

1

0

High-throughput

0.458

High

777259

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.458

High

913097

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

945636

PHLD
Phosphatidylinositol-glycan-specific phospholipase D

1

0

Small-scale

0.458

High

1045213

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

Small-scale

0.458

High

1173356

RFPLB
Ret finger protein-like 4B

1

0

High-throughput

0.458

High

1200646

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1326658

MKS1
Tectonic-like complex member MKS1

1

0

High-throughput

0.458

High

402454

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

608116

FGFR4
Fibroblast growth factor receptor 4

1

3

High-throughput

0.437

High

609524

FGFR3
Fibroblast growth factor receptor 3

1

3

High-throughput

0.437

High

654751

CALX
Calnexin

1

1

High-throughput

0.437

High

1081596

NTRK3
NT-3 growth factor receptor

1

4

High-throughput

0.437

High

1168413

LMTK1
Serine/threonine-protein kinase LMTK1

1

5

High-throughput

0.437

High

1326662

ALK
ALK tyrosine kinase receptor

1

3

High-throughput

0.437

High

670645

ERP29
Endoplasmic reticulum resident protein 29

1

0

High-throughput

0.269

Low

1084765

TAZ
Tafazzin

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024