HitPredict

Interactor 1: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Interactor 2: HSH2D (Q96JZ2)
Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X)
Gene: HSH2D

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 920 Hs			1 352
+	Hs
		454790 ANDR_HUMAN (1-920): 0: 966: 100.00		FGR_HUMAN (2-207): 1.19e-39: 148: 18.64
+	Hs
		433225 ANDR_HUMAN (1-920): 0: 966: 100.00		YES_HUMAN (2-181): 3.84e-38: 144: 17.07
+	Hs
		487778 ANDR_HUMAN (1-920): 0: 966: 100.00		SH22A_HUMAN (17-212): 4.9e-39: 144: 29.35
+	Hs
		487088 ANDR_HUMAN (1-920): 0: 966: 100.00		SRC_HUMAN (2-207): 1.8e-36: 139: 17.37
+	Hs
		411564 ANDR_HUMAN (1-920): 0: 966: 100.00		LCK_HUMAN (2-207): 1.04e-35: 137: 19.57
+	Hs
		442764 ANDR_HUMAN (1-920): 0: 966: 100.00		HCK_HUMAN (15-207): 1.82e-35: 137: 17.97
+	Hs
		275164 ANDR_HUMAN (1-920): 0: 966: 100.00		GRAP2_HUMAN (3-162): 2.51e-36: 135: 23.21
+	Hs
		487310 ANDR_HUMAN (1-920): 0: 966: 100.00		GRB2_HUMAN (14-150): 1.34e-34: 127: 24.66
+	Hs
		487415 ANDR_HUMAN (1-920): 0: 966: 100.00		PTK6_HUMAN (30-149): 1.47e-32: 127: 28.46
+	Hs
		487623 ANDR_HUMAN (1-920): 0: 966: 100.00		P55G_HUMAN (13-130): 1.15e-30: 122: 25.41
+	Hs
		487512 ANDR_HUMAN (1-920): 0: 966: 100.00		SHE_HUMAN (33-128): 1.67e-25: 108: 25.00
+	Hs
		487107 ANDR_HUMAN (1-920): 0: 966: 100.00		PLCG2_HUMAN (6-159): 1.15e-24: 107: 17.65
+	Hs
		487118 ANDR_HUMAN (1-920): 0: 966: 100.00		PLCG1_HUMAN (4-147): 2.82e-24: 106: 21.25
+	Hs
		487209 ANDR_HUMAN (1-920): 0: 966: 100.00		KSYK_HUMAN (33-142): 8.99e-18: 86.4: 27.59
+	Hs
		368834 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		YES_HUMAN (2-181): 3.84e-38: 144: 17.07
+	Hs
		368894 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		SRC_HUMAN (2-207): 1.8e-36: 139: 17.37
+	Rn
		411266 ESR1_RAT (378-904): 2.19e-130: 406: 20.94		SRC_RAT (2-207): 1.99e-36: 139: 17.37
+	Mm
		403414 ESR1_MOUSE (378-904): 2.5e-129: 403: 21.30		SRC_MOUSE (2-207): 3.48e-36: 139: 17.37
+	Hs
		377007 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		FYN_HUMAN (3-207): 5.32e-40: 149: 16.81
+	Hs
		377006 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		LCK_HUMAN (2-207): 1.04e-35: 137: 19.57