HitPredict

Interactor 1: RARA (P10276)
Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1)
Gene: RARA

Interactor 2: SP130 (Q9H0E3)
Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130)
Gene: SAP130

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	18212063
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 462 Hs			1 1048
+	Hs
		782650 HNF4A_HUMAN (61-462): 6.66e-120: 360: 24.52		SP130_HUMAN (1-1048): 2.19e-131: 426: 100.00
+	Hs
		368927 ESR1_HUMAN (5-460): 2.32e-119: 362: 21.81		MUC1_HUMAN (32-955): 1.16e-49: 194: 13.25
+	Hs
		554279 PPARG_HUMAN (66-416): 9.52e-115: 348: 30.26		MUC1_HUMAN (32-955): 1.16e-49: 194: 13.25
+	Hs
		369851 ESR1_HUMAN (5-460): 2.32e-119: 362: 21.81		ANR11_HUMAN (121-1011): 3.96e-42: 171: 12.56
+	Hs
		992427 PPARA_HUMAN (54-417): 8.72e-117: 352: 28.93		ANR11_HUMAN (121-1011): 3.96e-42: 171: 12.56
+	Hs
		554348 ESR2_HUMAN (3-447): 3.53e-106: 327: 24.89		MUC1_HUMAN (32-955): 1.16e-49: 194: 13.25
+	Hs
		369607 ESR1_HUMAN (5-460): 2.32e-119: 362: 21.81		MDC1_HUMAN (11-926): 1.17e-29: 130: 9.43
+	Hs
		782578 HNF4A_HUMAN (61-462): 6.66e-120: 360: 24.52		SRCAP_HUMAN (17-830): 2.84e-24: 112: 10.93
+	Hs
		1056909 ESR2_HUMAN (3-447): 3.53e-106: 327: 24.89		MDC1_HUMAN (11-926): 1.17e-29: 130: 9.43
+	Hs
		490111 COT1_HUMAN (1-430): 5.36e-122: 364: 25.69		CIC_HUMAN (284-939): 3.09e-10: 67: 10.76
+	Hs
		370251 ESR1_HUMAN (5-460): 2.32e-119: 362: 21.81		CIC_HUMAN (284-939): 3.09e-10: 67: 10.76
+	Hs
		370105 ESR1_HUMAN (5-460): 2.32e-119: 362: 21.81		TITIN_HUMAN (59-898): 8.03e-10: 65.5: 9.13
+	Hs
		782638 HNF4A_HUMAN (61-462): 6.66e-120: 360: 24.52		CIC_HUMAN (284-939): 3.09e-10: 67: 10.76
+	Hs
		370040 ESR1_HUMAN (5-460): 2.32e-119: 362: 21.81		KMT2C_HUMAN (364-832): 7.84e-09: 62.5: 15.83
+	Mm
		101828 ERR2_MOUSE (5-417): 5.86e-110: 333: 27.05		F8WI37_MOUSE (62-876): 4.57e-17: 89.5: 14.16
+	Mm
		1142676 ERR2_MOUSE (5-417): 5.86e-110: 333: 27.05		KMT2C_MOUSE (62-876): 4.49e-17: 89.5: 14.16
+	Hs
		782595 HNF4A_HUMAN (61-462): 6.66e-120: 360: 24.52		KMT2C_HUMAN (364-832): 7.84e-09: 62.5: 15.83
+	Hs
		622826 COT2_HUMAN (1-423): 5.64e-117: 351: 24.94		CIC_HUMAN (284-939): 3.09e-10: 67: 10.76
+	Hs
		740556 PPARG_HUMAN (66-416): 9.52e-115: 348: 30.26		KMT2C_HUMAN (364-832): 7.84e-09: 62.5: 15.83
+	Hs
		65044 ESR2_HUMAN (3-447): 3.53e-106: 327: 24.89		P121C_HUMAN (117-861): 1.12e-12: 74.7: 9.36