Protein: DPOE1
DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A)

Gene: DPOE1, POLE
Organism: Homo sapiens
Interactions: 119
UniProt ID: Q07864

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000166 - nucleotide binding
GO:0000278 - mitotic cell cycle
GO:0000731 - DNA synthesis involved in DNA repair
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

940484

DPOE2
DNA polymerase epsilon subunit 2

9

4

Small-scale

0.969

High

1060496

DPOE3
DNA polymerase epsilon subunit 3

4

2

Small-scale

0.691

High

551004

PCNA
Proliferating cell nuclear antigen

4

9

Small-scale

0.680

High

1060478

DNJC7
DnaJ homolog subfamily C member 7

3

4

High-throughput

0.667

High

371856

MYC
Myc proto-oncogene protein

3

3

High-throughput

0.662

High

1060477

MMS19
MMS19 nucleotide excision repair protein homolog

3

3

Small-scale

0.656

High

1060494

DPOE4
DNA polymerase epsilon subunit 4

3

2

Small-scale

0.650

High

1060471

LRC46
Leucine-rich repeat-containing protein 46

4

1

High-throughput

0.630

High

1060490

CIA2A
Cytosolic iron-sulfur assembly component 2A

2

3

High-throughput

0.611

High

1060442

TEBP
Prostaglandin E synthase 3

2

0

High-throughput

0.602

High

302817

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

3

5

Small-scale

0.585

High

1060448

SNPC4
snRNA-activating protein complex subunit 4

2

0

High-throughput

0.576

High

1060435

LG3BP
Galectin-3-binding protein

2

2

High-throughput

0.574

High

298595

RAD17
Cell cycle checkpoint protein RAD17

1

2

Small-scale

0.561

High

295574

CIB2
Calcium and integrin-binding family member 2

2

1

High-throughput

0.549

High

578465

BRAF
Serine/threonine-protein kinase B-raf

1

2

High-throughput

0.549

High

1060492

CLSPN
Claspin

1

0

Small-scale

0.537

High

133109

FOXE1
Forkhead box protein E1

1

5

High-throughput

0.536

High

158432

RFXK
DNA-binding protein RFXANK

1

3

High-throughput

0.536

High

537035

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.536

High

937621

FOXG1
Forkhead box protein G1

1

5

High-throughput

0.536

High

1041742

PPARD
Peroxisome proliferator-activated receptor delta

1

2

High-throughput

0.536

High

1060436

SSRP1
FACT complex subunit SSRP1

1

6

High-throughput

0.536

High

1060437

FOXL1
Forkhead box protein L1

1

5

High-throughput

0.536

High

1060470

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

1060479

NPAS1
Neuronal PAS domain-containing protein 1

1

1

High-throughput

0.536

High

1060480

FOXB1
Forkhead box protein B1

1

6

High-throughput

0.536

High

1060484

DUS16
Dual specificity protein phosphatase 16

1

3

High-throughput

0.536

High

1060485

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

1060486

FOXQ1
Forkhead box protein Q1

1

5

High-throughput

0.536

High

1060500

HSPB8
Heat shock protein beta-8

1

2

High-throughput

0.536

High

1060460

SH2D3
SH2 domain-containing protein 3C

2

4

High-throughput

0.521

High

563676

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

1060467

TOPB1
DNA topoisomerase 2-binding protein 1

1

5

Small-scale

0.515

High

70891

ZBBX
Zinc finger B-box domain-containing protein 1

1

0

High-throughput

0.513

High

261488

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

774762

TIMP3
Metalloproteinase inhibitor 3

1

0

High-throughput

0.513

High

1060453

LYPD4
Ly6/PLAUR domain-containing protein 4

1

0

High-throughput

0.513

High

1060447

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.501

High

1060481

SLD5
DNA replication complex GINS protein SLD5

1

7

Small-scale

0.501

High

1060493

DPOD4
DNA polymerase delta subunit 4

1

1

Small-scale

0.501

High

346977

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.489

High

859800

RL28
Large ribosomal subunit protein eL28

1

1

High-throughput

0.489

High

1060461

TTC9C
Tetratricopeptide repeat protein 9C

1

3

High-throughput

0.489

High

1060504

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

1

High-throughput

0.489

High

891936

WHR1
Winged helix repair factor 1

1

0

Small-scale

0.486

High

259849

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.479

High

345709

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

404003

GCR
Glucocorticoid receptor

1

4

High-throughput

0.479

High

411799

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

487230

PARP1
Poly [ADP-ribose] polymerase 1

1

4

High-throughput

0.479

High

766484

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

768031

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

799030

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.479

High

830617

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

883518

CENPA
Histone H3-like centromeric protein A

1

7

High-throughput

0.479

High

1052823

DUSP2
Dual specificity protein phosphatase 2

1

3

High-throughput

0.479

High

1060438

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

1060439

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

5

High-throughput

0.479

High

1060440

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.479

High

1060441

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1060444

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

1060445

DDB1
DNA damage-binding protein 1

1

3

Small-scale

0.479

High

1060457

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

1060459

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1060466

CTF18
Chromosome transmission fidelity protein 18 homolog

1

3

Small-scale

0.479

High

1060473

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1060476

CIC
Protein capicua homolog

1

3

High-throughput

0.479

High

1060482

DUS26
Dual specificity protein phosphatase 26

1

3

High-throughput

0.479

High

1060483

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

1

Small-scale

0.479

High

1060487

DUS15
Dual specificity protein phosphatase 15

1

3

High-throughput

0.479

High

1060489

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

1060491

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1060495

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

1060498

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

1

High-throughput

0.479

High

1060499

RTEL1
Regulator of telomere elongation helicase 1

1

1

Small-scale

0.479

High

1060502

FBW1B
F-box/WD repeat-containing protein 11

1

2

High-throughput

0.479

High

1060505

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

3

High-throughput

0.479

High

1060507

ARI1
E3 ubiquitin-protein ligase ARIH1

1

3

High-throughput

0.479

High

218096

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

722943

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

Small-scale

0.458

High

861582

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

0

Small-scale

0.458

High

1060443

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

0

High-throughput

0.458

High

1060452

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1060454

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1060463

DTWD2
tRNA-uridine aminocarboxypropyltransferase 2

1

0

High-throughput

0.458

High

1060468

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.458

High

1060506

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

238774

SSX4
Protein SSX4

1

1

High-throughput

0.445

High

273424

KDM4A
Lysine-specific demethylase 4A

1

3

Small-scale

0.445

High

911221

IMA5
Importin subunit alpha-5

1

2

High-throughput

0.445

High

941776

ARL4C
ADP-ribosylation factor-like protein 4C

1

2

High-throughput

0.445

High

943922

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

1060458

DDX46
Probable ATP-dependent RNA helicase DDX46

1

1

High-throughput

0.445

High

1060472

AURKB
Aurora kinase B

1

1

High-throughput

0.445

High

293609

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

1060446

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

1060455

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

1

High-throughput

0.437

High

1060488

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

1060503

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

226938

LIAS
Lipoyl synthase, mitochondrial

1

0

High-throughput

0.426

High

591284

CD44
CD44 antigen

1

0

High-throughput

0.426

High

616744

SDC1
Syndecan-1

1

0

High-throughput

0.426

High

896370

ERF
ETS domain-containing transcription factor ERF

1

0

High-throughput

0.426

High

1060464

RCBT1
RCC1 and BTB domain-containing protein 1

1

0

High-throughput

0.426

High

1060465

HAVR2
Hepatitis A virus cellular receptor 2

1

0

High-throughput

0.426

High

1060456

PKHG7
Pleckstrin homology domain-containing family G member 7

1

1

High-throughput

0.407

High

1060474

MERB1
bMERB domain-containing protein 1

2

0

High-throughput

0.328

High

1060501

DKKL1
Dickkopf-like protein 1

2

0

High-throughput

0.328

High

350363

ABHGA
Phosphatidylserine lipase ABHD16A

2

0

High-throughput

0.316

High

1060451

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.279

Low

1060450

BLT3A
Bridge-like lipid transfer protein family member 3A

1

0

High-throughput

0.269

Low

124318

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.249

Low

635127

ICAL
Calpastatin

1

0

High-throughput

0.249

Low

1060469

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.249

Low

1060475

YI001
Uncharacterized protein FLJ30774

1

0

High-throughput

0.249

Low

1060497

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low

1060449

ANR22
Ankyrin repeat domain-containing protein 22

1

0

High-throughput

0.232

Low

1060462

CI163
Uncharacterized protein C9orf163

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025