HitPredict

Interactor 1: HLAC (P10321)
HLA class I histocompatibility antigen, C alpha chain (HLA-C) (HLA-Cw) (Human leukocyte antigen C)
Gene: HLA-C

Interactor 2: KI2S1 (Q14954)
Killer cell immunoglobulin-like receptor 2DS1 (CD158 antigen-like family member H) (MHC class I NK cell receptor Eb6 ActI) (CD antigen CD158h)
Gene: KIR2DS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	28546555, 18624290
Identification Methods	affinity chromatography technology, fluorescence-activated cell sorting
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C1-set~ig, MHC_I~ig
Common GO terms	GO:0005886 - plasma membrane GO:0006955 - immune response GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 366 Hs			1 304
+	Hs
		798280 Q5S3G3_HUMAN (1-365): 2.13e-176: 496: 81.92		KI2S4_HUMAN (1-304): 3.59e-110: 323: 91.45
+	Hs
		798195 Q5S3G3_HUMAN (1-365): 2.13e-176: 496: 81.92		KI2L3_HUMAN (1-304): 5.29e-102: 304: 90.79
+	Hs
		798194 Q5RIP0_HUMAN (1-366): 3.87e-168: 475: 90.98		KI2L3_HUMAN (1-304): 5.29e-102: 304: 90.79
+	Hs
		798173 Q5RIP0_HUMAN (1-366): 3.87e-168: 475: 90.98		KI2L2_HUMAN (1-303): 9.5e-100: 298: 90.43
+	Hs
		798171 Q5D1W8_HUMAN (1-366): 2.02e-167: 473: 90.98		KI2L2_HUMAN (1-303): 9.5e-100: 298: 90.43
+	Hs
		798148 Q5RIP0_HUMAN (1-366): 3.87e-168: 475: 90.98		KI2L1_HUMAN (1-303): 8.01e-99: 295: 93.73
+	Hs
		798146 Q5D1W8_HUMAN (1-366): 2.02e-167: 473: 90.98		KI2L1_HUMAN (1-303): 8.01e-99: 295: 93.73
+	Hs
		382484 HLAA_HUMAN (1-365): 1.85e-176: 496: 81.37		LIRB4_HUMAN (1-298): 3.63e-66: 215: 34.07
+	Hs
		1060406 Q95J06_HUMAN (1-365): 0: 509: 79.73		KI3S1_HUMAN (1-246): 5.13e-53: 179: 37.75
+	Hs
		47499 HLAA_HUMAN (1-365): 1.85e-176: 496: 81.37		A0A8I5QEB2_HUMAN (1-246): 9.17e-56: 187: 40.96
+	Hs
		382420 HLAA_HUMAN (1-365): 1.85e-176: 496: 81.37		KI3S1_HUMAN (1-246): 5.13e-53: 179: 37.75
+	Hs
		382341 HLAA_HUMAN (1-365): 1.85e-176: 496: 81.37		KI3L2_HUMAN (1-246): 5.51e-52: 178: 40.56
+	Hs
		798244 Q5S3G3_HUMAN (1-365): 2.13e-176: 496: 81.92		KI3L2_HUMAN (1-246): 5.51e-52: 178: 40.56
+	Hs
		1060403 Q5SUL5_HUMAN (1-365): 1.81e-174: 491: 80.00		KI3S1_HUMAN (1-246): 5.13e-53: 179: 37.75
+	Hs
		1245576 Q95J06_HUMAN (1-365): 0: 509: 79.73		LIRB1_HUMAN (21-258): 6.9e-37: 141: 35.80
+	Hs
		1232786 Q95J06_HUMAN (1-365): 0: 509: 79.73		LIRB2_HUMAN (21-246): 4.75e-36: 137: 38.10
+	Hs
		1130838 Q5S3G3_HUMAN (1-365): 2.13e-176: 496: 81.92		LIRB1_HUMAN (21-258): 6.9e-37: 141: 35.80
+	Hs
		382485 HLAA_HUMAN (1-365): 1.85e-176: 496: 81.37		LIRB1_HUMAN (21-258): 6.9e-37: 141: 35.80
+	Hs
		1130837 Q5S3G3_HUMAN (1-365): 2.13e-176: 496: 81.92		LIRB2_HUMAN (21-246): 4.75e-36: 137: 38.10
+	Hs
		382478 HLAA_HUMAN (1-365): 1.85e-176: 496: 81.37		LIRB2_HUMAN (21-246): 4.75e-36: 137: 38.10