Protein: RB3GP
Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP)

Gene: RB3GP, RAB3GAP1
Organism: Homo sapiens
Interactions: 229
UniProt ID: Q15042

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005789 - endoplasmic reticulum membrane
GO:0005794 - Golgi apparatus
GO:0005801 - cis-Golgi network

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

333009

VAPB
Vesicle-associated membrane protein-associated protein B/C

6

3

Small-scale

0.732

High

1139408

VAPA
Vesicle-associated membrane protein-associated protein A

5

3

Small-scale

0.716

High

931190

BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

3

0

High-throughput

0.638

High

1139338

SIR2
NAD-dependent protein deacetylase sirtuin-2

3

0

High-throughput

0.638

High

488223

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

1

High-throughput

0.628

High

1139332

BT2A1
Butyrophilin subfamily 2 member A1

3

1

High-throughput

0.609

High

64868

RCCD1
RCC1 domain-containing protein 1

2

0

High-throughput

0.602

High

578483

BRAF
Serine/threonine-protein kinase B-raf

2

0

High-throughput

0.602

High

851325

PRS6B
26S proteasome regulatory subunit 6B

2

0

High-throughput

0.602

High

1139388

DOCK5
Dedicator of cytokinesis protein 5

2

0

High-throughput

0.602

High

1139383

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

2

0

Small-scale

0.585

High

1139418

ALK
ALK tyrosine kinase receptor

2

6

High-throughput

0.584

High

48628

ESYT2
Extended synaptotagmin-2

2

2

High-throughput

0.571

High

698675

CALX
Calnexin

2

1

High-throughput

0.571

High

1027007

REEP5
Receptor expression-enhancing protein 5

2

1

High-throughput

0.571

High

1139345

DHB11
Estradiol 17-beta-dehydrogenase 11

2

2

High-throughput

0.571

High

1139373

ESYT1
Extended synaptotagmin-1

2

1

High-throughput

0.571

High

1139378

LNP
Endoplasmic reticulum junction formation protein lunapark

2

1

High-throughput

0.571

High

1139381

DJC25
DnaJ homolog subfamily C member 25

2

1

High-throughput

0.571

High

903916

BAP31
B-cell receptor-associated protein 31

2

0

High-throughput

0.547

High

1139346

PDZD8
PDZ domain-containing protein 8

2

0

High-throughput

0.547

High

664046

PRTN3
Myeloblastin

1

3

High-throughput

0.536

High

773509

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.536

High

921901

COPA
Coatomer subunit alpha

1

1

High-throughput

0.536

High

1139324

REEP3
Receptor expression-enhancing protein 3

1

1

High-throughput

0.536

High

1139386

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

1

High-throughput

0.536

High

463967

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

2

3

High-throughput

0.533

High

988967

AP2B1
AP-2 complex subunit beta

1

1

High-throughput

0.515

High

158209

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.513

High

193776

PER1
Period circadian protein homolog 1

1

0

High-throughput

0.513

High

642552

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.513

High

788662

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

884450

PCY1A
Choline-phosphate cytidylyltransferase A

1

0

High-throughput

0.513

High

1013510

COG7
Conserved oligomeric Golgi complex subunit 7

1

0

High-throughput

0.513

High

1139358

YIPF5
Protein YIPF5

1

0

High-throughput

0.513

High

1139376

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

1139391

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

0

High-throughput

0.513

High

1139339

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

0

High-throughput

0.493

High

1139334

PK1L2
Polycystin-1-like protein 2

1

1

High-throughput

0.489

High

1133936

RB39A
Ras-related protein Rab-39A

1

1

Small-scale

0.481

High

1139363

RB39B
Ras-related protein Rab-39B

1

1

Small-scale

0.481

High

1139370

FEZ1
Fasciculation and elongation protein zeta-1

1

1

Small-scale

0.481

High

1139416

RB22A
Ras-related protein Rab-22A

1

3

Small-scale

0.481

High

1139419

RPH3L
Rab effector Noc2

1

0

Small-scale

0.480

High

126604

RHOD
Rho-related GTP-binding protein RhoD

1

1

High-throughput

0.479

High

188888

TMPS2
Transmembrane protease serine 2

1

3

High-throughput

0.479

High

404061

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

411959

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

439737

INSR
Insulin receptor

1

4

High-throughput

0.479

High

541493

FGFR1
Fibroblast growth factor receptor 1

1

3

High-throughput

0.479

High

631227

RAB5A
Ras-related protein Rab-5A

1

3

High-throughput

0.479

High

900824

RAB5C
Ras-related protein Rab-5C

1

3

High-throughput

0.479

High

910058

RND2
Rho-related GTP-binding protein RhoN

1

2

High-throughput

0.479

High

962063

RHOA
Transforming protein RhoA

1

1

High-throughput

0.479

High

1099913

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

1139320

IF44L
Interferon-induced protein 44-like

1

1

High-throughput

0.479

High

1139335

TM11B
Transmembrane protease serine 11B

1

3

High-throughput

0.479

High

1139365

DNJC1
DnaJ homolog subfamily C member 1

1

1

High-throughput

0.479

High

1139367

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

1

High-throughput

0.479

High

1139379

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

High-throughput

0.479

High

1139382

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

1

High-throughput

0.479

High

135219

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

0

High-throughput

0.458

High

173922

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

184294

NPHP1
Nephrocystin-1

1

0

High-throughput

0.458

High

241720

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

279167

ULK1
Serine/threonine-protein kinase ULK1

1

0

Small-scale

0.458

High

279369

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

372070

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

417448

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

418140

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

529821

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.458

High

611126

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

623350

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.458

High

704532

RXRB
Retinoic acid receptor RXR-beta

1

0

High-throughput

0.458

High

715591

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

830764

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

847539

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

880553

LMAN1
Protein ERGIC-53

1

0

Small-scale

0.458

High

894762

EMD
Emerin

1

0

High-throughput

0.458

High

901821

RAB9A
Ras-related protein Rab-9A

1

0

High-throughput

0.458

High

934631

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

942621

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

951159

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

1058424

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.458

High

1087116

STX4
Syntaxin-4

1

0

High-throughput

0.458

High

1111540

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

1125440

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

1139326

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1139328

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1139333

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1139337

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.458

High

1139348

FLCN
Folliculin

1

0

Small-scale

0.458

High

1139351

COP1
E3 ubiquitin-protein ligase COP1

1

0

High-throughput

0.458

High

1139353

DMXL2
DmX-like protein 2

1

0

Small-scale

0.458

High

1139357

GOGA1
Golgin subfamily A member 1

1

0

High-throughput

0.458

High

1139361

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1139369

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1139375

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1139387

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1139389

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1139394

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1139403

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

1139405

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

1139407

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1139409

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

1139412

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1139413

TES
Testin

1

0

High-throughput

0.458

High

1139421

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.458

High

1139424

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.458

High

275516

RTN2
Reticulon-2

1

2

High-throughput

0.445

High

328918

RTN3
Reticulon-3

1

2

High-throughput

0.445

High

437679

HEPS
Serine protease hepsin

1

3

High-throughput

0.445

High

628409

KLK2
Kallikrein-2

1

2

High-throughput

0.445

High

697884

CALR
Calreticulin

1

1

High-throughput

0.445

High

888871

TMEDA
Transmembrane emp24 domain-containing protein 10

1

2

High-throughput

0.445

High

921671

COPB
Coatomer subunit beta

1

1

High-throughput

0.445

High

1139315

TMED2
Transmembrane emp24 domain-containing protein 2

1

2

High-throughput

0.445

High

1139317

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

1

High-throughput

0.445

High

1139321

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

2

High-throughput

0.445

High

1139340

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

1

High-throughput

0.445

High

1139349

ATLA2
Atlastin-2

1

2

High-throughput

0.445

High

1139350

MSPD2
Motile sperm domain-containing protein 2

1

2

High-throughput

0.445

High

1139355

ATLA1
Atlastin-1

1

2

High-throughput

0.445

High

1139359

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.445

High

1139366

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.445

High

1139385

TMX1
Thioredoxin-related transmembrane protein 1

1

1

High-throughput

0.445

High

1139393

RTN4
Reticulon-4

1

2

High-throughput

0.445

High

1139410

COPG2
Coatomer subunit gamma-2

1

2

High-throughput

0.445

High

1139422

DHRS7
Dehydrogenase/reductase SDR family member 7

1

1

High-throughput

0.445

High

1139423

TMED5
Transmembrane emp24 domain-containing protein 5

1

2

High-throughput

0.445

High

1139427

COPG1
Coatomer subunit gamma-1

1

2

High-throughput

0.445

High

1139415

FEZ2
Fasciculation and elongation protein zeta-2

1

1

Small-scale

0.439

High

1139396

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

277359

TP4A3
Protein tyrosine phosphatase type IVA 3

1

1

High-throughput

0.437

High

465524

IGF1R
Insulin-like growth factor 1 receptor

1

5

High-throughput

0.437

High

777689

VGFR3
Vascular endothelial growth factor receptor 3

1

2

High-throughput

0.437

High

1139329

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1139397

TMPS4
Transmembrane protease serine 4

1

3

High-throughput

0.437

High

50558

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.426

High

60343

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.426

High

211790

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.426

High

213603

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.426

High

215565

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.426

High

248874

GSDME
Gasdermin-E

1

0

High-throughput

0.426

High

283253

ERLN1
Erlin-1

1

0

High-throughput

0.426

High

296500

STAM2
Signal transducing adapter molecule 2

1

0

High-throughput

0.426

High

320449

TM63A
Mechanosensitive cation channel TMEM63A

1

0

High-throughput

0.426

High

327265

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.426

High

359990

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.426

High

462424

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

0

High-throughput

0.426

High

535080

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

873227

COPD
Coatomer subunit delta

1

0

High-throughput

0.426

High

876862

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.426

High

883097

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

0

High-throughput

0.426

High

896381

ERF
ETS domain-containing transcription factor ERF

1

0

High-throughput

0.426

High

903699

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.426

High

964005

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.426

High

987036

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

High-throughput

0.426

High

1009835

NUCB2
Nucleobindin-2

1

0

High-throughput

0.426

High

1015024

ARF5
ADP-ribosylation factor 5

1

0

High-throughput

0.426

High

1096963

PRDX4
Peroxiredoxin-4

1

0

High-throughput

0.426

High

1131262

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.426

High

1136203

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.426

High

1139194

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.426

High

1139314

RCN1
Reticulocalbin-1

1

0

High-throughput

0.426

High

1139316

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.426

High

1139318

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.426

High

1139325

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.426

High

1139327

LCLT1
Lysocardiolipin acyltransferase 1

1

0

High-throughput

0.426

High

1139331

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

0

High-throughput

0.426

High

1139336

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

0

High-throughput

0.426

High

1139342

FXL16
F-box/LRR-repeat protein 16

1

0

High-throughput

0.426

High

1139343

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.426

High

1139344

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.426

High

1139347

VP37A
Vacuolar protein sorting-associated protein 37A

1

0

High-throughput

0.426

High

1139352

MCFD2
Multiple coagulation factor deficiency protein 2

1

0

High-throughput

0.426

High

1139354

SCFD1
Sec1 family domain-containing protein 1

1

0

High-throughput

0.426

High

1139362

ASTRA
Protein Aster-A

1

0

High-throughput

0.426

High

1139368

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

1139372

ERP44
Endoplasmic reticulum resident protein 44

1

0

High-throughput

0.426

High

1139377

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.426

High

1139380

RGAP1
Rac GTPase-activating protein 1

1

0

High-throughput

0.426

High

1139390

ZDH11
Palmitoyltransferase ZDHHC11

1

0

High-throughput

0.426

High

1139398

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.426

High

1139400

EXOC1
Exocyst complex component 1

1

0

High-throughput

0.426

High

1139404

PSD3
PH and SEC7 domain-containing protein 3

1

0

High-throughput

0.426

High

1139406

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.426

High

1139420

S27A6
Long-chain fatty acid transport protein 6

1

0

High-throughput

0.426

High

1139426

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.426

High

104339

F5H6I7
Atlastin GTPase 3

1

2

High-throughput

0.407

High

116514

H7C1K6
Interferon induced protein 44 like

1

1

High-throughput

0.407

High

1139356

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.407

High

1139322

CF141
Uncharacterized protein C6orf141

2

0

High-throughput

0.328

High

955879

GMFB
Glia maturation factor beta

2

0

High-throughput

0.313

High

711554

NK3R
Neuromedin-K receptor

1

0

High-throughput

0.279

Low

1037064

OC90
Otoconin-90

1

0

High-throughput

0.279

Low

1139384

ADNP
Activity-dependent neuroprotector homeobox protein

1

0

High-throughput

0.279

Low

105959

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

139874

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

588736

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

695500

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

768234

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

820644

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.249

Low

837624

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.249

Low

848385

MAGA6
Melanoma-associated antigen 6

1

0

High-throughput

0.249

Low

1137034

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

0

High-throughput

0.249

Low

1139323

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

1139330

PAXI1
PAX-interacting protein 1

1

0

High-throughput

0.249

Low

1139341

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.249

Low

1139360

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1139364

KTI12
Protein KTI12 homolog

1

0

Small-scale

0.249

Low

1139395

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1139399

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1139411

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

0

Small-scale

0.249

Low

1139414

SEC63
Translocation protein SEC63 homolog

1

0

High-throughput

0.249

Low

1139417

CLC4E
C-type lectin domain family 4 member E

1

0

High-throughput

0.249

Low

1139425

WDR7
WD repeat-containing protein 7

1

0

Small-scale

0.249

Low

295583

CIB2
Calcium and integrin-binding family member 2

1

0

High-throughput

0.232

Low

318982

MICA2
[F-actin]-monooxygenase MICAL2

1

0

High-throughput

0.232

Low

330157

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

466897

ACM4
Muscarinic acetylcholine receptor M4

1

0

High-throughput

0.232

Low

566983

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.232

Low

607926

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

0

High-throughput

0.232

Low

1139319

TMM95
Sperm-egg fusion protein TMEM95

1

0

High-throughput

0.232

Low

1139371

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.232

Low

1139374

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.232

Low

1139392

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.232

Low

1139401

TM38B
Trimeric intracellular cation channel type B

1

0

High-throughput

0.232

Low

1139402

GPTC2
G patch domain-containing protein 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025