HitPredict

Interactor 1: HLAC (P10321)
HLA class I histocompatibility antigen, C alpha chain (HLA-C) (HLA-Cw) (Human leukocyte antigen C)
Gene: HLA-C

Interactor 2: LIRB1 (Q8NHL6)
Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j)
Gene: LILRB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	12853576, 24018270
Identification Methods	pull down, surface plasmon resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C1-set~ig, C1-set~Ig_2, MHC_I~ig
Common GO terms	GO:0002250 - adaptive immune response GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 366 Hs			1 650
+	Hs
		1245576 Q95J06_HUMAN (1-365): 0: 509: 79.73		LIRB1_HUMAN (1-650): 2.42e-147: 443: 100.00
+	Hs
		1130838 Q5S3G3_HUMAN (1-365): 2.13e-176: 496: 81.92		LIRB1_HUMAN (1-650): 2.42e-147: 443: 100.00
+	Hs
		382485 HLAA_HUMAN (1-365): 1.85e-176: 496: 81.37		LIRB1_HUMAN (1-650): 2.42e-147: 443: 100.00
+	Hs
		1232786 Q95J06_HUMAN (1-365): 0: 509: 79.73		LIRB2_HUMAN (1-650): 2.34e-117: 364: 76.31
+	Hs
		1130837 Q5S3G3_HUMAN (1-365): 2.13e-176: 496: 81.92		LIRB2_HUMAN (1-650): 2.34e-117: 364: 76.31
+	Hs
		382478 HLAA_HUMAN (1-365): 1.85e-176: 496: 81.37		LIRB2_HUMAN (1-650): 2.34e-117: 364: 76.31
+	Hs
		1060406 Q95J06_HUMAN (1-365): 0: 509: 79.73		KI3S1_HUMAN (1-334): 4.36e-69: 231: 35.91
+	Hs
		382420 HLAA_HUMAN (1-365): 1.85e-176: 496: 81.37		KI3S1_HUMAN (1-334): 4.36e-69: 231: 35.91
+	Hs
		1060403 Q5SUL5_HUMAN (1-365): 1.81e-174: 491: 80.00		KI3S1_HUMAN (1-334): 4.36e-69: 231: 35.91
+	Hs
		382341 HLAA_HUMAN (1-365): 1.85e-176: 496: 81.37		KI3L2_HUMAN (1-334): 1.36e-63: 219: 35.91
+	Hs
		798244 Q5S3G3_HUMAN (1-365): 2.13e-176: 496: 81.92		KI3L2_HUMAN (1-334): 1.36e-63: 219: 35.91
+	Hs
		798280 Q5S3G3_HUMAN (1-365): 2.13e-176: 496: 81.92		KI2S4_HUMAN (120-337): 1.27e-52: 185: 38.36
+	Hs
		798195 Q5S3G3_HUMAN (1-365): 2.13e-176: 496: 81.92		KI2L3_HUMAN (319-581): 5.31e-33: 131: 22.92
+	Hs
		382484 HLAA_HUMAN (1-365): 1.85e-176: 496: 81.37		LIRB4_HUMAN (119-586): 1.76e-29: 124: 19.83
+	Hs
		798194 Q5RIP0_HUMAN (1-366): 3.87e-168: 475: 90.98		KI2L3_HUMAN (319-581): 5.31e-33: 131: 22.92
+	Hs
		798173 Q5RIP0_HUMAN (1-366): 3.87e-168: 475: 90.98		KI2L2_HUMAN (319-581): 4.84e-31: 126: 22.33
+	Hs
		798171 Q5D1W8_HUMAN (1-366): 2.02e-167: 473: 90.98		KI2L2_HUMAN (319-581): 4.84e-31: 126: 22.33
+	Hs
		798148 Q5RIP0_HUMAN (1-366): 3.87e-168: 475: 90.98		KI2L1_HUMAN (319-581): 8.17e-30: 122: 20.33
+	Hs
		798146 Q5D1W8_HUMAN (1-366): 2.02e-167: 473: 90.98		KI2L1_HUMAN (319-581): 8.17e-30: 122: 20.33
+	Hs
		47499 HLAA_HUMAN (1-365): 1.85e-176: 496: 81.37		A0A8I5QEB2_HUMAN (319-536): 2.04e-18: 90.1: 21.88