Protein: PPB1
Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1)

Gene: PPB1, ALPP
Organism: Homo sapiens
Interactions: 133
UniProt ID: P05187

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004035 - alkaline phosphatase activity
GO:0005886 - plasma membrane
GO:0008270 - zinc ion binding
GO:0009986 - cell surface

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

426042

PPBI
Intestinal-type alkaline phosphatase

2

4

High-throughput

0.811

High

426044

PPBN
Alkaline phosphatase, germ cell type

2

4

High-throughput

0.811

High

426051

KRA59
Keratin-associated protein 5-9

3

9

High-throughput

0.616

High

303099

RGS20
Regulator of G-protein signaling 20

2

1

High-throughput

0.606

High

426062

RGS19
Regulator of G-protein signaling 19

2

1

High-throughput

0.606

High

426074

CREB5
Cyclic AMP-responsive element-binding protein 5

2

1

High-throughput

0.606

High

426048

TGM1
Protein-glutamine gamma-glutamyltransferase K

2

0

High-throughput

0.580

High

426120

NR4A3
Nuclear receptor subfamily 4 group A member 3

2

0

High-throughput

0.580

High

426045

CFTR
Cystic fibrosis transmembrane conductance regulator

2

4

High-throughput

0.571

High

192356

GSC2
Homeobox protein goosecoid-2

2

4

High-throughput

0.553

High

426061

HXA1
Homeobox protein Hox-A1

2

2

High-throughput

0.553

High

426070

KR108
Keratin-associated protein 10-8

2

8

High-throughput

0.553

High

426076

KRA11
Keratin-associated protein 1-1

2

8

High-throughput

0.553

High

426090

LCE3E
Late cornified envelope protein 3E

2

2

High-throughput

0.553

High

426093

LCE1E
Late cornified envelope protein 1E

2

1

High-throughput

0.553

High

426097

LCE3A
Late cornified envelope protein 3A

2

2

High-throughput

0.553

High

426098

LCE3B
Late cornified envelope protein 3B

2

1

High-throughput

0.553

High

426112

KRA13
Keratin-associated protein 1-3

2

8

High-throughput

0.553

High

426132

LCE3D
Late cornified envelope protein 3D

2

2

High-throughput

0.553

High

244434

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

1

High-throughput

0.536

High

426053

PCSK6
Proprotein convertase subtilisin/kexin type 6

1

5

High-throughput

0.536

High

426079

HYAL2
Hyaluronidase-2

1

1

High-throughput

0.536

High

426080

SEM3B
Semaphorin-3B

1

1

High-throughput

0.536

High

426105

CSPG4
Chondroitin sulfate proteoglycan 4

1

2

High-throughput

0.536

High

426117

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

1

High-throughput

0.536

High

426119

KREM2
Kremen protein 2

1

1

High-throughput

0.536

High

426126

VMP1
Vacuole membrane protein 1

1

2

High-throughput

0.536

High

426139

ANLN
Anillin

2

1

High-throughput

0.533

High

426128

KR412
Keratin-associated protein 4-12

1

8

High-throughput

0.523

High

426046

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.513

High

426125

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.513

High

426153

JAG2
Protein jagged-2

1

0

High-throughput

0.513

High

426157

AGRG1
Adhesion G-protein coupled receptor G1

1

0

High-throughput

0.513

High

426143

NLGN3
Neuroligin-3

1

1

Small-scale

0.508

High

144035

MA2B1
Lysosomal alpha-mannosidase

1

1

High-throughput

0.489

High

160794

TOR1B
Torsin-1B

1

3

High-throughput

0.489

High

426041

BGLR
Beta-glucuronidase

1

1

High-throughput

0.489

High

426055

GALNS
N-acetylgalactosamine-6-sulfatase

1

2

High-throughput

0.489

High

426065

ANAG
Alpha-N-acetylglucosaminidase

1

1

High-throughput

0.489

High

426066

LAMB2
Laminin subunit beta-2

1

1

High-throughput

0.489

High

426106

ARSK
Arylsulfatase K

1

2

High-throughput

0.489

High

426110

MEGF8
Multiple epidermal growth factor-like domains protein 8

1

2

High-throughput

0.489

High

426111

ANR46
Ankyrin repeat domain-containing protein 46

1

1

High-throughput

0.489

High

426113

P3H3
Prolyl 3-hydroxylase 3

1

1

High-throughput

0.489

High

426114

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

1

High-throughput

0.489

High

426122

SC65
Endoplasmic reticulum protein SC65

1

1

High-throughput

0.489

High

426144

CHPF2
Chondroitin sulfate glucuronyltransferase

1

1

High-throughput

0.489

High

426155

MA2B2
Epididymis-specific alpha-mannosidase

1

1

High-throughput

0.489

High

348934

LATS1
Serine/threonine-protein kinase LATS1

1

0

Small-scale

0.480

High

178145

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.479

High

362582

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

410514

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

3

High-throughput

0.479

High

426058

BASI
Basigin

1

2

High-throughput

0.479

High

426083

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.479

High

426123

TF3B
Transcription factor IIIB 90 kDa subunit

1

2

Small-scale

0.479

High

426131

TX101
Testis-expressed protein 101

1

2

High-throughput

0.479

High

426134

ASPC1
Tether containing UBX domain for GLUT4

1

1

High-throughput

0.479

High

426145

HDAC6
Protein deacetylase HDAC6

1

3

High-throughput

0.479

High

426043

NT2NC
Notch homolog 2 N-terminal-like protein C

1

4

High-throughput

0.470

High

426103

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

220464

RNF13
E3 ubiquitin-protein ligase RNF13

1

0

Small-scale

0.458

High

426052

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

426082

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

0

High-throughput

0.458

High

426115

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.458

High

426137

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

426152

RIMS2
Regulating synaptic membrane exocytosis protein 2

1

0

High-throughput

0.458

High

426071

SUMO1
Small ubiquitin-related modifier 1

1

1

Small-scale

0.445

High

426136

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

426064

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.439

High

426069

KR103
Keratin-associated protein 10-3

1

8

High-throughput

0.439

High

426091

LCE1C
Late cornified envelope protein 1C

1

2

High-throughput

0.439

High

426095

LCE1B
Late cornified envelope protein 1B

1

1

High-throughput

0.439

High

426108

NT2NA
Notch homolog 2 N-terminal-like protein A

1

4

High-throughput

0.439

High

426133

KRA93
Keratin-associated protein 9-3

1

8

High-throughput

0.439

High

320609

UBXN7
UBX domain-containing protein 7

1

3

High-throughput

0.437

High

330565

KI20A
Kinesin-like protein KIF20A

1

7

High-throughput

0.437

High

426073

KIF23
Kinesin-like protein KIF23

1

4

High-throughput

0.437

High

426075

UBXN1
UBX domain-containing protein 1

1

2

High-throughput

0.437

High

426085

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.437

High

426124

FAF2
FAS-associated factor 2

1

3

High-throughput

0.437

High

426127

AURKB
Aurora kinase B

1

2

High-throughput

0.437

High

426135

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.437

High

426138

ECT2
Protein ECT2

1

1

High-throughput

0.437

High

426140

FBX6
F-box only protein 6

1

1

High-throughput

0.437

High

426150

FAF1
FAS-associated factor 1

1

4

High-throughput

0.437

High

426067

SUMO3
Small ubiquitin-related modifier 3

1

1

Small-scale

0.407

High

70081

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

426050

IBP6
Insulin-like growth factor-binding protein 6

2

0

High-throughput

0.316

High

426054

OTX1
Homeobox protein OTX1

2

0

High-throughput

0.316

High

426060

CXCL5
C-X-C motif chemokine 5

2

0

High-throughput

0.316

High

426063

MCSP
Sperm mitochondrial-associated cysteine-rich protein

2

0

High-throughput

0.316

High

426068

GEMI4
Gem-associated protein 4

2

0

High-throughput

0.316

High

426078

PO4F2
POU domain, class 4, transcription factor 2

2

0

High-throughput

0.316

High

426089

LCE3C
Late cornified envelope protein 3C

2

0

High-throughput

0.316

High

426092

LCE1D
Late cornified envelope protein 1D

2

0

High-throughput

0.316

High

426094

LCE1F
Late cornified envelope protein 1F

2

0

High-throughput

0.316

High

426096

LELP1
Late cornified envelope-like proline-rich protein 1

2

0

High-throughput

0.316

High

426100

LCE2C
Late cornified envelope protein 2C

2

0

High-throughput

0.316

High

426101

LCE5A
Late cornified envelope protein 5A

2

0

High-throughput

0.316

High

426107

ATL4
ADAMTS-like protein 4

2

0

High-throughput

0.316

High

426141

FBX34
F-box only protein 34

2

0

High-throughput

0.316

High

426146

CRCT1
Cysteine-rich C-terminal protein 1

2

0

High-throughput

0.316

High

426121

GPI8
GPI-anchor transamidase

2

0

Small-scale

0.310

High

426049

BDNF
Neurotrophic factor BDNF precursor form

1

0

High-throughput

0.279

Low

426057

IDUA
Alpha-L-iduronidase

1

0

High-throughput

0.279

Low

426059

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

0

High-throughput

0.279

Low

426072

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.279

Low

426077

MGT5A
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

1

0

High-throughput

0.279

Low

426086

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.279

Low

426087

GXLT1
Glucoside xylosyltransferase 1

1

0

High-throughput

0.279

Low

426102

METRL
Meteorin-like protein

1

0

High-throughput

0.279

Low

426104

GLT18
Polypeptide N-acetylgalactosaminyltransferase 18

1

0

High-throughput

0.279

Low

426116

PGLT1
Protein O-glucosyltransferase 1

1

0

High-throughput

0.279

Low

426118

UXS1
UDP-glucuronic acid decarboxylase 1

1

0

High-throughput

0.279

Low

426129

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

0

High-throughput

0.279

Low

426130

CHID1
Chitinase domain-containing protein 1

1

0

High-throughput

0.279

Low

426142

P4HTM
Transmembrane prolyl 4-hydroxylase

1

0

High-throughput

0.279

Low

426147

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.279

Low

426148

PCYOX
Prenylcysteine oxidase 1

1

0

High-throughput

0.279

Low

426149

PALD
Paladin

1

0

High-throughput

0.279

Low

426156

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.279

Low

461

NBPFJ
NBPF family member NBPF19

1

0

High-throughput

0.251

Low

426099

LCE4A
Late cornified envelope protein 4A

1

0

High-throughput

0.251

Low

426109

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.251

Low

212533

GPAA1
GPI-anchor transamidase component GPAA1

1

0

Small-scale

0.249

Low

378532

IL1B
Interleukin-1 beta

1

0

Small-scale

0.249

Low

426047

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

426056

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

426081

DX39B
Spliceosome RNA helicase DDX39B

1

0

Small-scale

0.249

Low

426084

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.249

Low

426088

UBX11
UBX domain-containing protein 11

1

0

High-throughput

0.249

Low

426151

NSF1C
NSFL1 cofactor p47

1

0

High-throughput

0.249

Low

426154

FBW1A
F-box/WD repeat-containing protein 1A

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025