HitPredict

Interactor 1: ARAF (P10398)
Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks)
Gene: ARAF

Interactor 2: GRP75 (P38646)
Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74)
Gene: HSPA9

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29777862
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005739 - mitochondrion GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 606 Hs			1 679
+	Hs
		488545 ARAF_HUMAN (1-606): 0: 579: 100.00		HSP7C_HUMAN (51-653): 0: 883: 50.16
+	Hs
		488563 ARAF_HUMAN (1-606): 0: 579: 100.00		HSP76_HUMAN (49-673): 0: 875: 48.68
+	Hs
		503368 BRAF_HUMAN (3-604): 0: 546: 56.68		HSP7C_HUMAN (51-653): 0: 883: 50.16
+	Mm
		655941 BRAF_MOUSE (3-604): 0: 542: 55.81		HSP7C_MOUSE (51-653): 0: 883: 50.16
+	Hs
		542812 BRAF_HUMAN (3-604): 0: 546: 56.68		HSP76_HUMAN (49-673): 0: 875: 48.68
+	Gg
		251126 BRAF_CHICK (3-604): 0: 542: 56.20		HSP7C_CHICK (51-653): 0: 877: 50.00
+	Hs
		542834 BRAF_HUMAN (3-604): 0: 546: 56.68		GRP75_HUMAN (1-679): 0: 873: 100.00
+	Hs
		373593 RAF1_HUMAN (13-606): 0: 534: 60.53		HSP7C_HUMAN (51-653): 0: 883: 50.16
+	Hs
		373642 RAF1_HUMAN (13-606): 0: 534: 60.53		HSP76_HUMAN (49-673): 0: 875: 48.68
+	Hs
		373811 RAF1_HUMAN (13-606): 0: 534: 60.53		GRP75_HUMAN (1-679): 0: 873: 100.00
+	Gg
		982839 BRAF_CHICK (3-604): 0: 542: 56.20		GRP75_CHICK (1-679): 0: 863: 90.62
+	Hs
		374331 RAF1_HUMAN (13-606): 0: 534: 60.53		Q53FC7_HUMAN (49-673): 0: 870: 48.37
+	Mm
		655932 BRAF_MOUSE (3-604): 0: 542: 55.81		GRP75_MOUSE (1-679): 0: 861: 98.38
+	Hs
		433227 YES_HUMAN (289-568): 3.31e-104: 327: 31.34		HSP7C_HUMAN (51-653): 0: 883: 50.16
+	Hs
		433277 YES_HUMAN (289-568): 3.31e-104: 327: 31.34		GRP75_HUMAN (1-679): 0: 873: 100.00
+	Hs
		488544 ARAF_HUMAN (1-606): 0: 579: 100.00		BIP_HUMAN (53-677): 0: 566: 50.55
+	Hs
		501634 BRAF_HUMAN (3-604): 0: 546: 56.68		BIP_HUMAN (53-677): 0: 566: 50.55
+	Gg
		982845 BRAF_CHICK (3-604): 0: 542: 56.20		BIP_CHICK (53-677): 0: 570: 52.13
+	Mm
		588704 BRAF_MOUSE (3-604): 0: 542: 55.81		BIP_MOUSE (53-677): 0: 567: 51.97
+	Hs
		373591 RAF1_HUMAN (13-606): 0: 534: 60.53		BIP_HUMAN (53-677): 0: 566: 50.55