Protein: RIR4
Ribonucleoside-diphosphate reductase small chain 2 (EC 1.17.4.1) (Ribonucleotide reductase R2 subunit 2) (Ribonucleotide reductase small subunit 2)

Gene: RIR4, RNR4
Organism: Saccharomyces cerevisiae S288C
Interactions: 101
UniProt ID: P49723

Gene Ontology (top 5):
GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005971 - ribonucleoside-diphosphate reductase complex
GO:0009263 - deoxyribonucleotide biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

488625

RIR2
Ribonucleoside-diphosphate reductase small chain 1

13

15

Small-scale

0.984

High

887754

RIR4
Ribonucleoside-diphosphate reductase small chain 2

3

15

Small-scale

0.834

High

638731

RIR1
Ribonucleoside-diphosphate reductase large chain 1

2

14

Small-scale

0.777

High

887777

WTM1
Transcriptional modulator WTM1

5

3

Small-scale

0.721

High

887775

WTM2
Transcriptional modulator WTM2

5

3

Small-scale

0.707

High

524511

HSP71
Heat shock protein SSA1

5

6

Small-scale

0.697

High

393015

HSP82
ATP-dependent molecular chaperone HSP82

4

6

High-throughput

0.676

High

527133

HSP72
Heat shock protein SSA2

3

6

Small-scale

0.629

High

639563

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

14

High-throughput

0.618

High

736678

ASF1
Histone chaperone ASF1

2

1

High-throughput

0.601

High

887780

HUG1
MEC1-mediated checkpoint protein HUG1

2

1

Small-scale

0.595

High

670911

SIS1
Protein SIS1

2

3

High-throughput

0.588

High

727173

HS104
Heat shock protein 104

2

3

High-throughput

0.584

High

850096

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

676155

MAS5
Mitochondrial protein import protein MAS5

2

2

Small-scale

0.571

High

721385

MCM4
DNA replication licensing factor MCM4

1

2

Small-scale

0.552

High

545507

SSB1
Ribosome-associated molecular chaperone SSB1

2

6

High-throughput

0.552

High

150338

DIF1
Damage-regulated import facilitator 1

1

1

Small-scale

0.501

High

602555

PHO85
Cyclin-dependent protein kinase PHO85

1

1

High-throughput

0.501

High

651961

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

1

High-throughput

0.501

High

692399

KCC1
Calcium/calmodulin-dependent protein kinase I

1

1

High-throughput

0.501

High

750274

PRP40
Pre-mRNA-processing protein PRP40

1

1

High-throughput

0.501

High

801871

KSP1
Serine/threonine-protein kinase KSP1

1

1

High-throughput

0.501

High

887768

ESA1
Histone acetyltransferase ESA1

1

1

Small-scale

0.501

High

637243

PWP1
Periodic tryptophan protein 1

1

4

High-throughput

0.500

High

737640

HIR1
Protein HIR1

1

2

High-throughput

0.500

High

887761

CAF1B
Chromatin assembly factor 1 subunit B

1

2

High-throughput

0.500

High

438540

UBC2
Ubiquitin-conjugating enzyme E2 2

1

0

High-throughput

0.493

High

887759

IMA1
Importin subunit alpha

1

0

High-throughput

0.493

High

887763

IMB1
Importin subunit beta-1

1

0

High-throughput

0.493

High

887769

YP191
Ubiquitin carboxyl-terminal hydrolase MIY1

1

0

High-throughput

0.493

High

869108

CTH1
mRNA decay factor CTH1

1

3

Small-scale

0.481

High

869115

CTH2
mRNA decay factor CTH2

1

3

Small-scale

0.481

High

887779

CMR1
DNA damage-binding protein CMR1

1

1

High-throughput

0.481

High

518076

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.480

High

574716

KSS1
Mitogen-activated protein kinase KSS1

1

0

High-throughput

0.480

High

778948

KKQ8
Probable serine/threonine-protein kinase KKQ8

1

0

High-throughput

0.480

High

849913

WWM1
WW domain-containing protein WWM1

1

0

High-throughput

0.480

High

863292

CTK2
CTD kinase subunit beta

1

0

High-throughput

0.480

High

863927

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

0

High-throughput

0.480

High

864415

IKS1
Probable serine/threonine-protein kinase IKS1

1

0

High-throughput

0.480

High

887766

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.480

High

887767

PSK2
Serine/threonine-protein kinase PSK2

1

0

High-throughput

0.480

High

829826

PAC11
WD repeat-containing protein PAC11

1

0

High-throughput

0.479

High

579719

HSC82
ATP-dependent molecular chaperone HSC82

1

6

High-throughput

0.479

High

594458

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

649644

KCC2
Calcium/calmodulin-dependent protein kinase II

1

1

High-throughput

0.479

High

679857

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

707605

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

780663

SRX1
Sulfiredoxin

1

1

High-throughput

0.479

High

803614

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

806770

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

808858

UME6
Transcriptional regulatory protein UME6

1

1

High-throughput

0.479

High

815173

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

887756

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

887757

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

2

High-throughput

0.479

High

887764

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

887765

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.479

High

887771

YO283
Broad-specificity phosphatase YOR283W

1

2

High-throughput

0.479

High

887772

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

368463

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

416456

HXKA
Hexokinase-1

1

0

High-throughput

0.458

High

439381

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.458

High

450735

KAD2
Adenylate kinase

1

0

High-throughput

0.458

High

647165

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

763936

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

764115

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

818546

YEY6
MYG1 protein YER156C

1

0

Small-scale

0.458

High

824839

PANC
Pantoate--beta-alanine ligase

1

0

High-throughput

0.458

High

865669

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

887773

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

887774

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

836298

BNI1
Protein BNI1

1

1

High-throughput

0.457

High

887755

FMP48
Probable serine/threonine-protein kinase FMP48

1

1

High-throughput

0.457

High

481683

HSP73
Heat shock protein SSA3

1

6

High-throughput

0.445

High

741945

HSP7F
Heat shock protein homolog SSE1

1

10

High-throughput

0.445

High

752489

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.445

High

811474

XDJ1
DnaJ protein homolog XDJ1

1

2

High-throughput

0.445

High

812247

YM11
Uncharacterized protein YMR124W

1

1

High-throughput

0.445

High

819224

SSB2
Ribosome-associated molecular chaperone SSB2

1

6

High-throughput

0.445

High

782382

RPF2
Ribosome biogenesis protein RPF2

1

1

High-throughput

0.437

High

887758

MLP1
Protein MLP1

1

2

High-throughput

0.437

High

887770

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

887778

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

721640

RENT1
ATP-dependent helicase NAM7

1

0

High-throughput

0.426

High

782656

PXL1
Paxillin-like protein 1

1

0

High-throughput

0.426

High

844413

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.426

High

887776

HSP42
Heat shock protein 42

1

0

High-throughput

0.426

High

871433

HLJ1
Protein HLJ1

1

2

High-throughput

0.407

High

506375

NFT1
ABC transporter NFT1

1

0

High-throughput

0.282

High

887760

PKH3
Serine/threonine-protein kinase PKH3

1

0

High-throughput

0.261

Low

887762

ISR1
Serine/threonine-protein kinase ISR1

1

0

High-throughput

0.261

Low

748186

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

High-throughput

0.261

Low

823358

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.261

Low

506397

YK104
Putative uncharacterized protein YKR104W

1

0

High-throughput

0.251

Low

555107

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.249

Low

795092

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

796994

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.249

Low

800641

YGP1
Protein YGP1

1

0

High-throughput

0.249

Low

887781

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025