HitPredict

Interactor 1: THIO (P10599)
Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) (allergen Hom s Trx)
Gene: TXN

Interactor 2: PRDX2 (P32119)
Peroxiredoxin-2 (EC 1.11.1.24) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2)
Gene: PRDX2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	25402766, 17557078
Identification Methods	pull down, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	1-cysPrx_C~Thioredoxin, AhpC-TSA~Thioredoxin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045454 - cell redox homeostasis GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 105 Hs			1 198
+	Hs
		495510 THIO_HUMAN (1-105): 6.33e-41: 132: 100.00		PRDX1_HUMAN (1-197): 7.49e-100: 288: 77.78
+	Mm
		956730 THIOM_MOUSE (5-105): 1.25e-33: 115: 34.95		PRDX2_MOUSE (1-198): 2.97e-104: 299: 93.43
+	Hs
		685729 TXND5_HUMAN (12-105): 2.13e-27: 105: 27.00		PRDX2_HUMAN (1-198): 3.46e-104: 299: 100.00
+	Mm
		589514 THIOM_MOUSE (5-105): 1.25e-33: 115: 34.95		PRDX3_MOUSE (2-198): 1.77e-98: 287: 63.45
+	Mm
		727682 THIOM_MOUSE (5-105): 1.25e-33: 115: 34.95		PRDX1_MOUSE (1-197): 2.61e-99: 287: 76.26
+	Mm
		139927 THIOM_MOUSE (5-105): 1.25e-33: 115: 34.95		PRDX4_MOUSE (5-198): 3.83e-97: 284: 69.07
+	Hs
		531737 PDIA4_HUMAN (3-104): 4.21e-25: 99.4: 23.85		PRDX3_HUMAN (2-198): 8.33e-101: 293: 63.45
+	Sc
		606199 TRX1_YEAST (1-102): 8.34e-39: 126: 47.06		TSA1_YEAST (6-198): 1.78e-89: 262: 66.84
+	Sc
		611720 TRX2_YEAST (1-105): 1.08e-38: 126: 47.62		TSA1_YEAST (6-198): 1.78e-89: 262: 66.84
+	Hs
		1026726 TXND5_HUMAN (12-105): 2.13e-27: 105: 27.00		PRDX4_HUMAN (5-198): 2.62e-96: 282: 70.10
+	Hs
		531815 PDIA4_HUMAN (3-104): 4.21e-25: 99.4: 23.85		PRDX4_HUMAN (5-198): 2.62e-96: 282: 70.10
+	So
		188731 TRXM_SPIOL (2-105): 1.38e-35: 120: 28.70		BAS1_SPIOL (6-195): 7.22e-87: 258: 63.35
+	Sc
		606220 TRX1_YEAST (1-102): 8.34e-39: 126: 47.06		TSA2_YEAST (6-198): 2.52e-85: 251: 62.18
+	Sc
		611752 TRX2_YEAST (1-105): 1.08e-38: 126: 47.62		TSA2_YEAST (6-198): 2.52e-85: 251: 62.18
+	Ss
		852832 THIO_SYNY3 (6-105): 1.71e-34: 115: 31.37		Y755_SYNY3 (6-195): 1.26e-89: 262: 57.59
+	At
		1280846 TRXF1_ARATH (2-102): 4.37e-33: 114: 41.18		BAS1A_ARATH (6-195): 7.14e-87: 258: 63.02
+	Mm
		139705 THIOM_MOUSE (5-105): 1.25e-33: 115: 34.95		PRDX6_MOUSE (4-196): 5.15e-72: 219: 29.13
+	Sc
		630634 TRX3_YEAST (2-104): 2.44e-35: 118: 41.75		PRX1_YEAST (6-198): 7.37e-68: 209: 31.22
+	Ss
		852787 THIO_SYNY3 (6-105): 1.71e-34: 115: 31.37		P73348_SYNY3 (5-196): 5.31e-69: 210: 30.30
+	Dm
		1177773 THIO2_DROME (1-105): 5.65e-36: 119: 49.06		Q7JX87_DROME (7-193): 6.19e-22: 90.5: 32.83