HitPredict

Interactor 1: CP51 (P10614)
Lanosterol 14-alpha demethylase CYP51 (EC 1.14.14.154) (Cytochrome P450 51) (Cytochrome P450-14DM) (Cytochrome P450-LIA1) (CYPLI) (Ergosterol biosynthetic protein 11) (Lanosterol C14-C32 lyase) (Sterol 14-alpha demethylase)
Gene: ERG11

Interactor 2: ERG25 (P53045)
C-4 methylsterol oxidase ERG25 (EC 1.14.18.-) (Ergosterol biosynthetic protein 25) (Sterol-C4-methyl oxidase ERG25) (SMO)
Gene: ERG25

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.632

Property	Details
Experiments	16300994, 18467557
Identification Methods	protein complementation assay, ubiquitin reconstruction, dihydrofolate reductase reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005506 - iron ion binding GO:0005789 - endoplasmic reticulum membrane GO:0006696 - ergosterol biosynthetic process
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 530 Sc			1 309
+	Sc
		495828 CP51_YEAST (1-530): 5e-143: 424: 100.00		SUR2_YEAST (51-303): 1.01e-54: 183: 20.36
+	Sc
		495806 CP51_YEAST (1-530): 5e-143: 424: 100.00		ERG3_YEAST (52-307): 6.45e-44: 155: 17.90
+	Hs
		1078794 CP4FN_HUMAN (282-486): 1.1e-18: 90.9: 28.16		MSMO1_HUMAN (17-301): 9.21e-87: 263: 37.24