HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: NUCL (P19338)
Nucleolin (Protein C23)
Gene: NCL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.678

Property	Details
Experiments	36634849, 32812023, 26269332, 35063084
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0036464 - cytoplasmic ribonucleoprotein granule
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 710
+	Mm
		449409 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		NUCL_MOUSE (1-650): 6.1e-99: 321: 76.07
+	Hs
		496179 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55
+	Hs
		496957 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PABP4_HUMAN (222-488): 1.86e-42: 165: 14.88
+	Hs
		496346 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ELAV4_HUMAN (464-709): 5.73e-44: 164: 18.82
+	Hs
		582292 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		NUCL_HUMAN (1-650): 8.84e-98: 318: 100.00
+	Rn
		582032 TAU_RAT (1-758): 4.86e-75: 260: 71.47		PABP1_RAT (222-482): 5.13e-43: 167: 15.55
+	Rn
		94258 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		PABP1_RAT (222-482): 5.13e-43: 167: 15.55
+	Hs
		582417 PRG4_HUMAN (4-604): 5.21e-20: 97.8: 8.93		NUCL_HUMAN (1-650): 8.84e-98: 318: 100.00
+	Mm
		498050 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		ELAV4_MOUSE (464-709): 6.98e-44: 164: 18.43
+	Mm
		498054 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		Q62029_MOUSE (222-482): 6.17e-42: 163: 16.25
+	Hs
		516595 KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91		PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55