HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: RAB3A (P20336)
Ras-related protein Rab-3A
Gene: RAB3A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	36634849, 35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030424 - axon GO:0030674 - protein-macromolecule adaptor activity
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 220
+	Hs
		496280 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RAB3B_HUMAN (1-220): 2.99e-92: 271: 77.73
+	Hs
		496764 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RAB1A_HUMAN (12-220): 2.68e-90: 265: 44.02
+	Hs
		497425 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RAB3C_HUMAN (1-220): 9.59e-89: 262: 84.09
+	Hs
		497392 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RAB8B_HUMAN (15-219): 1.11e-87: 259: 46.34
+	Hs
		497581 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RAB1B_HUMAN (15-220): 4.83e-88: 259: 43.20
+	Hs
		320118 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RAB3D_HUMAN (1-220): 1.18e-85: 254: 76.82
+	Hs
		496701 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RAB14_HUMAN (12-220): 9.33e-85: 252: 34.42
+	Hs
		496754 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RB11A_HUMAN (12-219): 8.65e-85: 252: 34.27
+	Mm
		497980 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		RAB3C_MOUSE (1-220): 1.29e-95: 280: 83.18
+	Mm
		497979 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		RAB1A_MOUSE (12-220): 2.68e-90: 265: 44.02
+	Mm
		497935 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		RAB3D_MOUSE (1-220): 4.07e-88: 260: 75.46
+	Mm
		498132 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		RAB1B_MOUSE (15-220): 5.57e-88: 259: 43.20
+	Hs
		108975 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		H0YNE9_HUMAN (17-191): 1.39e-64: 199: 52.57
+	Hs
		496696 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RAB10_HUMAN (15-202): 7.98e-64: 198: 49.74
+	Mm
		497961 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		RAB10_MOUSE (15-202): 7.98e-64: 198: 49.74
+	Dm
		627443 CPN_DROME (345-756): 7.29e-11: 67.8: 11.17		RAB3_DROME (1-220): 9.14e-94: 275: 76.47