Protein: CLPA
ATP-dependent Clp protease ATP-binding subunit ClpA

Gene: CLPA
Organism: Escherichia coli K-12
Interactions: 81
UniProt ID: P0ABH9

Gene Ontology (top 5):
GO:0004176 - ATP-dependent peptidase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

495716

CLPS
ATP-dependent Clp protease adapter protein ClpS

8

3

Small-scale

0.965

High

490253

CLPP
ATP-dependent Clp protease proteolytic subunit

4

4

Small-scale

0.902

High

498372

SSPB
Stringent starvation protein B

2

1

High-throughput

0.759

High

498369

BARA
Signal transduction histidine-protein kinase BarA

3

3

High-throughput

0.663

High

490304

CLPX
ATP-dependent Clp protease ATP-binding subunit ClpX

1

14

High-throughput

0.625

High

496892

LON
Lon protease

1

11

High-throughput

0.618

High

395151

UVRD
DNA helicase II

2

3

High-throughput

0.588

High

473272

DNAJ
Chaperone protein DnaJ

2

9

High-throughput

0.588

High

492230

PYRH
Uridylate kinase

2

1

High-throughput

0.588

High

492483

RL7
Large ribosomal subunit protein bL12

2

1

High-throughput

0.588

High

492866

RL27
Large ribosomal subunit protein bL27

2

3

High-throughput

0.588

High

493228

RS10
Small ribosomal subunit protein uS10

2

5

High-throughput

0.588

High

497478

RL13
Large ribosomal subunit protein uL13

2

5

High-throughput

0.588

High

498370

GYRA
DNA gyrase subunit A

2

2

High-throughput

0.588

High

498376

RL21
Large ribosomal subunit protein bL21

2

1

High-throughput

0.588

High

498377

RS14
Small ribosomal subunit protein uS14

2

1

High-throughput

0.588

High

498378

RS1
Small ribosomal subunit protein bS1

2

3

High-throughput

0.588

High

498379

SRP54
Signal recognition particle protein

2

1

High-throughput

0.588

High

498381

RL18
Large ribosomal subunit protein uL18

2

1

High-throughput

0.588

High

498382

IBPA
Small heat shock protein IbpA

2

1

High-throughput

0.588

High

498383

RLME
Ribosomal RNA large subunit methyltransferase E

2

1

High-throughput

0.588

High

498387

SBCC
Nuclease SbcCD subunit C

2

8

High-throughput

0.588

High

498388

PROV
Glycine betaine/proline betaine transport system ATP-binding protein ProV

2

3

High-throughput

0.588

High

498389

PUR4
Phosphoribosylformylglycinamidine synthase

2

2

High-throughput

0.588

High

498396

RLMN
Dual-specificity RNA methyltransferase RlmN

2

1

High-throughput

0.588

High

498409

DXS
1-deoxy-D-xylulose-5-phosphate synthase

2

5

High-throughput

0.588

High

498384

EFTU1
Elongation factor Tu 1

2

9

High-throughput

0.571

High

382566

RS6
Small ribosomal subunit protein bS6

2

0

High-throughput

0.563

High

493088

RL33
Large ribosomal subunit protein bL33

2

0

High-throughput

0.563

High

493145

RL9
Large ribosomal subunit protein bL9

2

0

High-throughput

0.563

High

494787

SSRP
SsrA-binding protein

2

0

High-throughput

0.563

High

498380

YHBY
RNA-binding protein YhbY

2

0

High-throughput

0.563

High

498402

FLAV
Flavodoxin 1

2

0

High-throughput

0.563

High

498405

RS21
Small ribosomal subunit protein bS21

2

0

High-throughput

0.563

High

489247

UBIB
Probable protein kinase UbiB

1

4

High-throughput

0.536

High

496627

LDCI
Inducible lysine decarboxylase

1

1

High-throughput

0.536

High

498368

CHEY
Chemotaxis protein CheY

1

3

High-throughput

0.536

High

498375

RL17
Large ribosomal subunit protein bL17

1

1

High-throughput

0.536

High

498391

NADE
NH(3)-dependent NAD(+) synthetase

1

1

High-throughput

0.536

High

498398

LDCC
Constitutive lysine decarboxylase

1

1

High-throughput

0.536

High

498399

RL2
Large ribosomal subunit protein uL2

1

4

High-throughput

0.536

High

492095

PPK1
Polyphosphate kinase

1

0

High-throughput

0.513

High

498397

MSCM
Miniconductance mechanosensitive channel MscM

1

6

High-throughput

0.489

High

382675

RS7
Small ribosomal subunit protein uS7

1

6

High-throughput

0.484

High

491053

DNAK
Chaperone protein DnaK

1

14

High-throughput

0.484

High

493033

RL29
Large ribosomal subunit protein uL29

1

1

High-throughput

0.484

High

493722

RS2
Small ribosomal subunit protein uS2

1

9

High-throughput

0.484

High

494063

RS4
Small ribosomal subunit protein uS4

1

1

High-throughput

0.484

High

495806

RPOC
DNA-directed RNA polymerase subunit beta'

1

10

High-throughput

0.484

High

495893

RPOB
DNA-directed RNA polymerase subunit beta

1

9

High-throughput

0.484

High

498373

SPOT
Bifunctional

1

1

High-throughput

0.484

High

498374

RHO
Transcription termination factor Rho

1

8

High-throughput

0.484

High

498392

MUKB
Chromosome partition protein MukB

1

9

High-throughput

0.484

High

498395

CBPA
Curved DNA-binding protein

1

7

High-throughput

0.484

High

498400

RL3
Large ribosomal subunit protein uL3

1

5

High-throughput

0.484

High

498403

RL5
Large ribosomal subunit protein uL5

1

2

High-throughput

0.484

High

498408

HSCC
Chaperone protein HscC

1

20

High-throughput

0.484

High

490142

CH10
Co-chaperonin GroES

1

5

High-throughput

0.479

High

491612

KPRS
Ribose-phosphate pyrophosphokinase

1

6

High-throughput

0.479

High

496279

CSPE
Cold shock-like protein CspE

1

3

High-throughput

0.479

High

497400

CSPC
Cold shock-like protein CspC

1

3

High-throughput

0.479

High

490671

FABZ
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

1

0

High-throughput

0.464

High

492375

RL10
Large ribosomal subunit protein uL10

1

0

High-throughput

0.464

High

493475

RS16
Small ribosomal subunit protein bS16

1

0

High-throughput

0.464

High

498386

SECA
Protein translocase subunit SecA

1

0

High-throughput

0.464

High

498401

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.464

High

491488

IF3
Translation initiation factor IF-3 [Cleaved into: Translation initiation factor IF-3, N-terminally processed; Translation initiation factor IF-3S]

1

0

High-throughput

0.458

High

498385

EFTU2
Elongation factor Tu 2

1

9

High-throughput

0.445

High

494560

RNPA
Ribonuclease P protein component

2

0

High-throughput

0.307

High

498390

RHSC
Protein RhsC

2

0

High-throughput

0.307

High

498394

3PASE
Inorganic triphosphatase

2

0

High-throughput

0.307

High

498407

LYSO
Lysine exporter LysO

2

0

High-throughput

0.307

High

498404

FIXX
Ferredoxin-like protein FixX

1

0

High-throughput

0.304

High

498371

YEIW
UPF0153 protein YeiW

1

0

High-throughput

0.282

High

498410

MQSA
Antitoxin MqsA

1

0

High-throughput

0.282

High

449943

FHUA
Ferrichrome outer membrane transporter/phage receptor

1

0

High-throughput

0.279

Low

469364

YCIH
Uncharacterized protein YciH

1

0

High-throughput

0.279

Low

497855

FDNH
Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit

1

0

High-throughput

0.279

Low

497954

YBAA
Uncharacterized protein YbaA

1

0

High-throughput

0.279

Low

498393

HOLC
DNA polymerase III subunit chi

1

0

High-throughput

0.253

Low

498406

INSN1
Putative transposase InsN for insertion sequence element IS911A

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025