HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: CASPE (P31944)
Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]
Gene: CASP14

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	26402096
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 242
+	Hs
		496654 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP7_HUMAN (7-241): 1.72e-89: 268: 26.91
+	Hs
		496377 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP1_HUMAN (6-241): 3.79e-86: 262: 24.71
+	Hs
		496496 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP3_HUMAN (11-241): 2.94e-87: 261: 29.80
+	Hs
		497029 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP8_HUMAN (12-241): 7.41e-80: 249: 29.58
+	Hs
		496655 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP6_HUMAN (8-241): 7.15e-80: 243: 28.46
+	Hs
		496497 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP2_HUMAN (16-241): 5.86e-77: 241: 29.20
+	Hs
		788201 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		CASP3_HUMAN (11-241): 2.94e-87: 261: 29.80