HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: STIP1 (P31948)
Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)
Gene: STIP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	26269332, 35063084
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0051879 - Hsp90 protein binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 543
+	Rn
		193483 TAU_RAT (1-758): 4.86e-75: 260: 71.47		STIP1_RAT (1-543): 1.66e-96: 305: 97.61
+	Rn
		94104 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		STIP1_RAT (1-543): 1.66e-96: 305: 97.61
+	Hs
		174574 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		OGT1_HUMAN (5-261): 5.16e-18: 90: 13.57
+	Hs
		297026 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TOM70_HUMAN (207-543): 4.08e-13: 73.8: 11.00
+	Hs
		213466 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SGTA_HUMAN (202-327): 3.98e-09: 60.1: 32.54
+	Rn
		582023 TAU_RAT (1-758): 4.86e-75: 260: 71.47		TOM70_RAT (207-543): 2.04e-11: 68.4: 10.23
+	Rn
		94249 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		TOM70_RAT (207-543): 2.04e-11: 68.4: 10.23
+	Hs
		174891 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		OGT1_HUMAN (5-261): 5.16e-18: 90: 13.57
+	Hs
		175053 KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91		OGT1_HUMAN (5-261): 5.16e-18: 90: 13.57
+	Dm
		1370278 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q9VSK6_DROME (2-254): 4.58e-11: 68: 13.28