HitPredict

Interactor 1: RHG10 (A1A4S6)
Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (GRAF2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10)
Gene: ARHGAP10

Interactor 2: RHG26 (Q9UNA1)
Rho GTPase-activating protein 26 (GTPase regulator associated with focal adhesion kinase) (GRAF1) (Oligophrenin-1-like protein) (Rho-type GTPase-activating protein 26)
Gene: ARHGAP26

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	28514442, 27173435, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BAR_3~BAR_3, BAR_3~PH, PH~PH, PH~SH3_9, RhoGAP~RhoGAP, SH3_9~SH3_9
Common GO terms	GO:0005096 - GTPase activator activity GO:0005829 - cytosol GO:0007165 - signal transduction GO:0010008 - endosome membrane GO:0051056 - regulation of small GTPase mediated signal transduction
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 786 Hs			1 814
+	Hs
		63085 RHG26_HUMAN (1-786): 6.21e-178: 532: 53.17		RHG42_HUMAN (1-814): 1.3e-177: 535: 48.91
+	Hs
		245186 RHG26_HUMAN (1-786): 6.21e-178: 532: 53.17		OPHN1_HUMAN (1-790): 1.86e-159: 485: 42.79
+	Hs
		49621 RHG10_HUMAN (1-786): 0: 602: 100.00		C9J6V4_HUMAN (300-390): 1.75e-56: 189: 100.00
+	Hs
		63062 RHG42_HUMAN (1-746): 5.36e-154: 473: 50.13		C9J6V4_HUMAN (300-390): 1.75e-56: 189: 100.00
+	Hs
		87296 OPHN1_HUMAN (1-758): 1.77e-153: 469: 42.90		C9J6V4_HUMAN (300-390): 1.75e-56: 189: 100.00
+	Hs
		1066128 ACAP3_HUMAN (5-453): 3.64e-81: 279: 22.29		ACAP2_HUMAN (5-434): 6.2e-87: 294: 21.41
+	Hs
		200194 SRGP3_HUMAN (21-732): 7.37e-71: 254: 14.46		SRGP3_HUMAN (21-782): 7.54e-91: 311: 13.90
+	Hs
		253374 SRGP1_HUMAN (21-733): 8.39e-74: 262: 15.23		SRGP2_HUMAN (16-774): 5.65e-84: 291: 12.63
+	Hs
		1089302 RHG17_HUMAN (130-748): 6.51e-85: 290: 15.74		RHG44_HUMAN (343-739): 7.55e-75: 262: 20.05
+	Hs
		200200 SRGP3_HUMAN (21-732): 7.37e-71: 254: 14.46		SRGP2_HUMAN (16-774): 5.65e-84: 291: 12.63
+	Hs
		1243506 DP13B_HUMAN (3-375): 2.48e-70: 245: 18.91		DP13B_HUMAN (2-521): 4.73e-76: 262: 14.93
+	Hs
		64650 CHIN_HUMAN (396-574): 1.59e-71: 243: 38.89		RHG32_HUMAN (338-740): 1.15e-71: 259: 21.41
+	Hs
		957808 RHG04_HUMAN (20-785): 9.05e-69: 246: 14.09		RHG04_HUMAN (17-732): 6.21e-70: 250: 13.52
+	Hs
		551042 CHIN_HUMAN (396-574): 1.59e-71: 243: 38.89		CHIO_HUMAN (389-568): 3.97e-71: 243: 34.81
+	Hs
		1243523 DP13B_HUMAN (3-375): 2.48e-70: 245: 18.91		DP13A_HUMAN (2-370): 4.64e-67: 238: 18.02
+	Hs
		200223 SRGP3_HUMAN (21-732): 7.37e-71: 254: 14.46		RHG24_HUMAN (248-724): 1.23e-63: 229: 17.65