Protein: ACKR3
Atypical chemokine receptor 3 (C-X-C chemokine receptor type 7) (CXC-R7) (CXCR-7) (Chemokine orphan receptor 1) (G-protein coupled receptor 159) (G-protein coupled receptor RDC1 homolog) (RDC-1)

Gene: ACKR3
Organism: Homo sapiens
Interactions: 117
UniProt ID: P25106

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001570 - vasculogenesis
GO:0005044 - scavenger receptor activity
GO:0005768 - endosome
GO:0005769 - early endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

669312

CXCR4
C-X-C chemokine receptor type 4

2

17

Small-scale

0.776

High

443663

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

4

7

High-throughput

0.699

High

669296

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

4

7

High-throughput

0.699

High

669308

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

4

2

High-throughput

0.699

High

669306

V1AR
Vasopressin V1a receptor

1

16

Small-scale

0.691

High

669309

ARRB1
Beta-arrestin-1

1

13

Small-scale

0.618

High

612345

ADA2B
Alpha-2B adrenergic receptor

1

20

Small-scale

0.575

High

669158

ADA1D
Alpha-1D adrenergic receptor

1

20

Small-scale

0.575

High

669302

ADA1A
Alpha-1A adrenergic receptor

1

19

Small-scale

0.575

High

669303

HRH1
Histamine H1 receptor

1

20

High-throughput

0.575

High

669304

ADA1B
Alpha-1B adrenergic receptor

1

19

Small-scale

0.575

High

669319

BMPR2
Bone morphogenetic protein receptor type-2

1

2

High-throughput

0.575

High

669355

PI3R4
Phosphoinositide 3-kinase regulatory subunit 4

1

3

High-throughput

0.575

High

395514

ESR1
Estrogen receptor

2

9

High-throughput

0.571

High

669298

CXB2
Gap junction beta-2 protein

1

10

High-throughput

0.536

High

413216

P53
Cellular tumor antigen p53

1

0

High-throughput

0.518

High

669367

AT132
Polyamine-transporting ATPase 13A2

1

20

Small-scale

0.494

High

298667

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

1

High-throughput

0.489

High

669333

HECD2
Probable E3 ubiquitin-protein ligase HECTD2

1

8

High-throughput

0.489

High

217847

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

669313

GRB2
Growth factor receptor-bound protein 2

1

10

High-throughput

0.479

High

669349

ESR2
Estrogen receptor beta

1

9

High-throughput

0.479

High

324546

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

133727

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

1

High-throughput

0.445

High

173658

BTAF1
TATA-binding protein-associated factor 172

1

7

High-throughput

0.445

High

184119

RER1
Protein RER1

1

4

High-throughput

0.445

High

214519

RASL2
Ras GTPase-activating protein 4

1

2

High-throughput

0.445

High

229893

ATP9B
Probable phospholipid-transporting ATPase IIB

1

20

High-throughput

0.445

High

230754

EXTL3
Exostosin-like 3

1

3

High-throughput

0.445

High

248561

FADS1
Acyl-CoA

1

10

High-throughput

0.445

High

270622

ATP9A
Probable phospholipid-transporting ATPase IIA

1

11

High-throughput

0.445

High

299067

FLOT1
Flotillin-1

1

5

High-throughput

0.445

High

336259

BRI3
Membrane protein BRI3

1

3

High-throughput

0.445

High

462988

YES
Tyrosine-protein kinase Yes

1

7

High-throughput

0.445

High

522595

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

6

High-throughput

0.445

High

622520

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

2

High-throughput

0.445

High

658632

JAK1
Tyrosine-protein kinase JAK1

1

20

High-throughput

0.445

High

658848

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

6

High-throughput

0.445

High

669297

STOM
Stomatin

1

5

High-throughput

0.445

High

669300

CTR1
High affinity cationic amino acid transporter 1

1

14

High-throughput

0.445

High

669301

MRP1
Multidrug resistance-associated protein 1

1

9

High-throughput

0.445

High

669305

TGFR2
TGF-beta receptor type-2

1

2

High-throughput

0.445

High

669307

HD
Huntingtin

1

4

High-throughput

0.445

High

669311

RAB13
Ras-related protein Rab-13

1

2

High-throughput

0.445

High

669314

AT2C1
Calcium-transporting ATPase type 2C member 1

1

20

High-throughput

0.445

High

669315

MUC24
Sialomucin core protein 24

1

1

Small-scale

0.445

High

669316

ATM
Serine-protein kinase ATM

1

20

High-throughput

0.445

High

669317

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

6

High-throughput

0.445

High

669321

FZD2
Frizzled-2

1

3

High-throughput

0.445

High

669324

ANO6
Anoctamin-6

1

2

High-throughput

0.445

High

669329

AG10B
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

1

8

High-throughput

0.445

High

669334

RIF1
Telomere-associated protein RIF1

1

5

High-throughput

0.445

High

669335

ZFY26
Zinc finger FYVE domain-containing protein 26

1

8

High-throughput

0.445

High

669342

ZDH17
Palmitoyltransferase ZDHHC17

1

12

High-throughput

0.445

High

669343

LRC8A
Volume-regulated anion channel subunit LRRC8A

1

9

High-throughput

0.445

High

669345

AN13A
Ankyrin repeat domain-containing protein 13A

1

4

High-throughput

0.445

High

669347

TM87A
Transmembrane protein 87A

1

10

High-throughput

0.445

High

669353

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

6

High-throughput

0.445

High

669354

SPTCS
Spatacsin

1

3

High-throughput

0.445

High

669356

OSMR
Oncostatin-M-specific receptor subunit beta

1

8

High-throughput

0.445

High

669358

NDC1
Nucleoporin NDC1

1

3

High-throughput

0.445

High

669360

STRA6
Receptor for retinol uptake STRA6

1

3

High-throughput

0.445

High

669361

TACAN
Transmembrane protein 120A

1

5

High-throughput

0.445

High

669366

IL1AP
Interleukin-1 receptor accessory protein

1

2

High-throughput

0.445

High

669371

AASS
Alpha-aminoadipic semialdehyde synthase, mitochondrial

1

1

High-throughput

0.445

High

669372

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

15

High-throughput

0.445

High

669375

AGRG1
Adhesion G-protein coupled receptor G1

1

12

High-throughput

0.445

High

626074

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

9

Small-scale

0.437

High

669295

TYY1
Transcriptional repressor protein YY1

1

2

Small-scale

0.437

High

669362

RM04
Large ribosomal subunit protein uL4m

1

1

High-throughput

0.437

High

669310

S26A2
Sulfate transporter

1

0

High-throughput

0.426

High

669357

SYT11
Synaptotagmin-11

1

0

High-throughput

0.426

High

117326

K7ES61
Large ribosomal subunit protein uL4m

1

1

High-throughput

0.407

High

161284

ENC1
Ectoderm-neural cortex protein 1

1

2

High-throughput

0.407

High

187463

FANCA
Fanconi anemia group A protein

1

6

High-throughput

0.407

High

211730

ZW10
Centromere/kinetochore protein zw10 homolog

1

4

High-throughput

0.407

High

243892

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

3

High-throughput

0.407

High

273162

CAND2
Cullin-associated NEDD8-dissociated protein 2

1

17

High-throughput

0.407

High

317441

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

1

1

High-throughput

0.407

High

326923

UBE4B
Ubiquitin conjugation factor E4 B

1

3

High-throughput

0.407

High

341237

ASML
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase

1

1

High-throughput

0.407

High

593572

GDC
Solute carrier family 25 member 16

1

16

High-throughput

0.407

High

665517

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

4

High-throughput

0.407

High

669318

MTX1
Metaxin-1

1

7

High-throughput

0.407

High

669320

URB2
Unhealthy ribosome biogenesis protein 2 homolog

1

3

High-throughput

0.407

High

669325

GPAT3
Glycerol-3-phosphate acyltransferase 3

1

17

High-throughput

0.407

High

669326

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

1

14

High-throughput

0.407

High

669327

TM177
Transmembrane protein 177

1

1

High-throughput

0.407

High

669328

TM41B
Transmembrane protein 41B

1

2

High-throughput

0.407

High

669330

SYEM
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial

1

3

High-throughput

0.407

High

669331

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.407

High

669332

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

4

High-throughput

0.407

High

669336

D19L2
Probable C-mannosyltransferase DPY19L2

1

3

High-throughput

0.407

High

669337

ZNT6
Zinc transporter 6

1

14

High-throughput

0.407

High

669339

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

4

High-throughput

0.407

High

669341

ZDH13
Palmitoyltransferase ZDHHC13

1

11

High-throughput

0.407

High

669344

K2013
Uncharacterized protein KIAA2013

1

4

High-throughput

0.407

High

669348

SFXN5
Sideroflexin-5

1

12

High-throughput

0.407

High

669350

INT12
Integrator complex subunit 12

1

5

High-throughput

0.407

High

669351

RN185
E3 ubiquitin-protein ligase RNF185

1

8

High-throughput

0.407

High

669359

PTSS2
Phosphatidylserine synthase 2

1

9

High-throughput

0.407

High

669363

INT2
Integrator complex subunit 2

1

3

High-throughput

0.407

High

669365

PCX3
Pecanex-like protein 3

1

1

High-throughput

0.407

High

669368

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

1

5

High-throughput

0.407

High

669369

OTULL
Inactive ubiquitin thioesterase OTULINL

1

2

High-throughput

0.407

High

669374

FADS3
Fatty acid desaturase 3

1

10

High-throughput

0.407

High

669299

ATPD
ATP synthase F(1) complex subunit delta, mitochondrial

2

0

High-throughput

0.318

High

669322

ESPL1
Separin

1

0

High-throughput

0.279

Low

669346

UBR7
Putative E3 ubiquitin-protein ligase UBR7

1

0

High-throughput

0.279

Low

669338

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

298143

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.232

Low

669323

HMGN3
High mobility group nucleosome-binding domain-containing protein 3

1

0

High-throughput

0.232

Low

669340

PIGW
Glucosaminyl-phosphatidylinositol-acyltransferase PIGW

1

0

High-throughput

0.232

Low

669352

INT4
Integrator complex subunit 4

1

0

High-throughput

0.232

Low

669364

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

0

High-throughput

0.232

Low

669370

B4GT7
Beta-1,4-galactosyltransferase 7

1

0

High-throughput

0.232

Low

669373

MYRF
Myelin regulatory factor

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025