Protein: VAV
Proto-oncogene vav

Gene: VAV, VAV1
Organism: Homo sapiens
Interactions: 196
UniProt ID: P15498

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

548677

GRB2
Growth factor receptor-bound protein 2

9

20

Small-scale

0.972

High

548696

LCP2
Lymphocyte cytosolic protein 2

6

16

Small-scale

0.936

High

337872

EGFR
Epidermal growth factor receptor

6

20

Small-scale

0.934

High

548656

KSYK
Tyrosine-protein kinase SYK

4

20

Small-scale

0.921

High

548682

3BP2
SH3 domain-binding protein 2

4

10

Small-scale

0.918

High

548645

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

4

20

Small-scale

0.904

High

548678

RAC1
Ras-related C3 botulinum toxin substrate 1

3

20

Small-scale

0.853

High

337333

ABL1
Tyrosine-protein kinase ABL1

2

20

Small-scale

0.847

High

548671

CDC42
Cell division control protein 42 homolog

3

20

Small-scale

0.840

High

548655

ZAP70
Tyrosine-protein kinase ZAP-70

3

20

Small-scale

0.827

High

181787

SOCS1
Suppressor of cytokine signaling 1

3

20

Small-scale

0.827

High

548632

ARF4
ADP-ribosylation factor 4

3

3

High-throughput

0.817

High

238345

JAK2
Tyrosine-protein kinase JAK2

2

20

Small-scale

0.806

High

548634

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

8

Small-scale

0.806

High

548672

RHOA
Transforming protein RhoA

2

20

Small-scale

0.778

High

548648

MK01
Mitogen-activated protein kinase 1

2

3

Small-scale

0.776

High

411981

FYN
Tyrosine-protein kinase Fyn

2

20

Small-scale

0.757

High

548650

TYK2
Non-receptor tyrosine-protein kinase TYK2

2

20

Small-scale

0.754

High

548639

CBL
E3 ubiquitin-protein ligase CBL

7

20

Small-scale

0.747

High

383580

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.738

High

548637

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

20

High-throughput

0.738

High

299235

FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2

2

10

High-throughput

0.737

High

452342

PGFRB
Platelet-derived growth factor receptor beta

2

20

Small-scale

0.727

High

548662

KLK7
Kallikrein-7

2

1

High-throughput

0.726

High

548701

SLAP1
Src-like-adapter

1

20

Small-scale

0.724

High

548712

SHB
SH2 domain-containing adapter protein B

1

20

Small-scale

0.724

High

548703

GAB1
GRB2-associated-binding protein 1

1

19

High-throughput

0.692

High

548658

NOTC1
Neurogenic locus notch homolog protein 1

1

2

High-throughput

0.691

High

548767

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

19

Small-scale

0.691

High

548653

IL6RB
Interleukin-6 receptor subunit beta

1

11

Small-scale

0.681

High

428001

TBB5
Tubulin beta chain

4

10

Small-scale

0.672

High

548187

CD19
B-lymphocyte antigen CD19

3

3

Small-scale

0.664

High

548729

TBA1A
Tubulin alpha-1A chain

3

10

Small-scale

0.660

High

154130

CHK1
Serine/threonine-protein kinase Chk1

1

0

High-throughput

0.656

High

548695

MERTK
Tyrosine-protein kinase Mer

1

20

Small-scale

0.653

High

349105

RASH
GTPase HRas

1

18

Small-scale

0.647

High

411288

INSR
Insulin receptor

1

20

Small-scale

0.647

High

548643

IKBA
NF-kappa-B inhibitor alpha

1

5

Small-scale

0.647

High

548649

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

20

Small-scale

0.647

High

548706

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.647

High

548711

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

548732

ABI1
Abl interactor 1

1

20

Small-scale

0.647

High

548749

RGAP1
Rac GTPase-activating protein 1

1

14

Small-scale

0.647

High

548756

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

4

Small-scale

0.647

High

548699

CBLB
E3 ubiquitin-protein ligase CBL-B

2

20

Small-scale

0.639

High

207420

LAT
Linker for activation of T-cells family member 1

2

6

Small-scale

0.629

High

548675

ACTA
Actin, aortic smooth muscle

2

10

High-throughput

0.628

High

548685

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

1

High-throughput

0.628

High

548691

APLP2
Amyloid beta precursor like protein 2

2

5

High-throughput

0.628

High

548718

ACTBL
Beta-actin-like protein 2

2

16

High-throughput

0.628

High

548722

CYTSA
Cytospin-A

2

20

High-throughput

0.628

High

548731

SPA12
Serpin A12

2

1

High-throughput

0.628

High

548768

NUB1
NEDD8 ultimate buster 1

2

1

High-throughput

0.628

High

161301

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

7

High-throughput

0.618

High

167461

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

5

Small-scale

0.618

High

254039

WDR1
WD repeat-containing protein 1

1

7

High-throughput

0.618

High

267875

EED
Polycomb protein EED

1

6

Small-scale

0.618

High

373633

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

8

Small-scale

0.618

High

548628

VAV
Proto-oncogene vav

1

17

High-throughput

0.618

High

548630

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

6

Small-scale

0.618

High

548635

EPOR
Erythropoietin receptor

1

18

Small-scale

0.618

High

548654

TEC
Tyrosine-protein kinase Tec

1

20

Small-scale

0.618

High

548657

CRK
Adapter molecule crk

1

20

Small-scale

0.618

High

548687

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

10

Small-scale

0.618

High

548689

KPCT
Protein kinase C theta type

1

11

Small-scale

0.618

High

548690

BTK
Tyrosine-protein kinase BTK

1

20

Small-scale

0.618

High

548721

A16L1
Autophagy-related protein 16-1

1

17

High-throughput

0.618

High

548727

POTEE
POTE ankyrin domain family member E

1

17

High-throughput

0.618

High

548737

BLNK
B-cell linker protein

1

20

Small-scale

0.618

High

548738

DOCK2
Dedicator of cytokinesis protein 2

1

6

Small-scale

0.618

High

548761

ANFY1
Rabankyrin-5

1

5

High-throughput

0.618

High

548713

CDSN
Corneodesmosin

2

0

High-throughput

0.602

High

548723

PLBL1
Phospholipase B-like 1

2

0

High-throughput

0.602

High

548735

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

2

0

High-throughput

0.602

High

548629

PRLR
Prolactin receptor

2

20

Small-scale

0.595

High

548692

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

2

8

Small-scale

0.595

High

548673

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

3

1

High-throughput

0.578

High

548751

GHC1
Mitochondrial glutamate carrier 1

3

8

High-throughput

0.578

High

548715

EZH2
Histone-lysine N-methyltransferase EZH2

2

2

Small-scale

0.576

High

411580

LCK
Tyrosine-protein kinase Lck

1

20

Small-scale

0.575

High

548766

PLAK2
PALM2-AKAP2 fusion protein

2

2

High-throughput

0.574

High

199084

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

4

Small-scale

0.573

High

523495

XRCC6
X-ray repair cross-complementing protein 6

1

4

Small-scale

0.573

High

548665

GDIR2
Rho GDP-dissociation inhibitor 2

1

1

Small-scale

0.573

High

225837

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

3

High-throughput

0.571

High

243282

DNJA2
DnaJ homolog subfamily A member 2

2

6

High-throughput

0.571

High

382291

HLAA
HLA class I histocompatibility antigen, A alpha chain

2

2

High-throughput

0.571

High

388203

HSPB1
Heat shock protein beta-1

2

5

High-throughput

0.571

High

393017

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

2

2

High-throughput

0.571

High

397256

ADT2
ADP/ATP translocase 2

2

5

High-throughput

0.571

High

515796

PRPS2
Ribose-phosphate pyrophosphokinase 2

2

3

High-throughput

0.571

High

548642

ATPA
ATP synthase subunit alpha, mitochondrial

2

4

High-throughput

0.571

High

548644

PYR1
Multifunctional protein CAD

2

8

High-throughput

0.571

High

548651

DNJA1
DnaJ homolog subfamily A member 1

2

6

High-throughput

0.571

High

548659

AL1A3
Retinaldehyde dehydrogenase 3

2

1

High-throughput

0.571

High

548661

EFTU
Elongation factor Tu, mitochondrial

2

6

High-throughput

0.571

High

548670

PRPS1
Ribose-phosphate pyrophosphokinase 1

2

3

High-throughput

0.571

High

548676

RL23
Large ribosomal subunit protein uL14

2

2

High-throughput

0.571

High

548679

RL38
Large ribosomal subunit protein eL38

2

1

High-throughput

0.571

High

548680

TBA1B
Tubulin alpha-1B chain

2

10

High-throughput

0.571

High

548681

TBB4B
Tubulin beta-4B chain

2

10

High-throughput

0.571

High

548683

S25A3
Solute carrier family 25 member 3

2

7

High-throughput

0.571

High

548688

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

2

10

High-throughput

0.571

High

548693

SRSF4
Serine/arginine-rich splicing factor 4

2

14

High-throughput

0.571

High

548700

PSMD2
26S proteasome non-ATPase regulatory subunit 2

2

1

High-throughput

0.571

High

548704

TBB3
Tubulin beta-3 chain

2

10

High-throughput

0.571

High

548707

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

2

3

High-throughput

0.571

High

548725

TBA3E
Tubulin alpha-3E chain

2

8

High-throughput

0.571

High

548770

NS1BP
Influenza virus NS1A-binding protein

2

4

High-throughput

0.571

High

548734

ZN655
Zinc finger protein 655

1

0

Small-scale

0.561

High

380729

S100B
Protein S100-B

1

8

Small-scale

0.561

High

548694

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.547

High

548760

VAPA
Vesicle-associated membrane protein-associated protein A

2

0

High-throughput

0.547

High

528480

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.541

High

487102

ANDR
Androgen receptor

1

15

High-throughput

0.536

High

259825

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

1

High-throughput

0.536

High

397006

PAI2
Plasminogen activator inhibitor 2

1

1

High-throughput

0.536

High

548686

DSG1
Desmoglein-1

1

5

High-throughput

0.536

High

548739

APBB2
Amyloid beta precursor protein binding family B member 2

1

1

High-throughput

0.536

High

548742

DNJC1
DnaJ homolog subfamily C member 1

1

6

High-throughput

0.536

High

507829

FGFR1
Fibroblast growth factor receptor 1

1

20

Small-scale

0.527

High

548746

DOK1
Docking protein 1

1

15

Small-scale

0.527

High

518236

ADT3
ADP/ATP translocase 3

2

5

High-throughput

0.521

High

548667

TXTP
Tricarboxylate transport protein, mitochondrial

2

8

High-throughput

0.521

High

548702

SRSF6
Serine/arginine-rich splicing factor 6

2

15

High-throughput

0.521

High

548716

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

2

2

High-throughput

0.521

High

548740

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

2

1

High-throughput

0.521

High

548762

DIC
Mitochondrial dicarboxylate carrier

2

9

High-throughput

0.521

High

506095

ITAM
Integrin alpha-M

1

2

Small-scale

0.515

High

548754

SMC4
Structural maintenance of chromosomes protein 4

1

7

High-throughput

0.515

High

548750

PHAX
Phosphorylated adapter RNA export protein

1

0

High-throughput

0.486

High

548730

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

2

Small-scale

0.481

High

117090

DX39A
ATP-dependent RNA helicase DDX39A

1

10

High-throughput

0.479

High

149541

COPE
Coatomer subunit epsilon

1

3

High-throughput

0.479

High

150515

ABLM1
Actin-binding LIM protein 1

1

16

High-throughput

0.479

High

162384

XPO1
Exportin-1

1

8

High-throughput

0.479

High

165808

KDM6B
Lysine-specific demethylase 6B

1

7

Small-scale

0.479

High

201654

MSI1H
RNA-binding protein Musashi homolog 1

1

16

High-throughput

0.479

High

231374

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

1

2

High-throughput

0.479

High

279427

FLOT1
Flotillin-1

1

11

High-throughput

0.479

High

381112

TBB4A
Tubulin beta-4A chain

1

10

High-throughput

0.479

High

396609

ITB2
Integrin beta-2

1

2

Small-scale

0.479

High

421961

LDHB
L-lactate dehydrogenase B chain

1

2

High-throughput

0.479

High

499342

CD28
T-cell-specific surface glycoprotein CD28

1

1

Small-scale

0.479

High

524780

XRCC5
X-ray repair cross-complementing protein 5

1

4

Small-scale

0.479

High

548633

EGR1
Early growth response protein 1

1

3

High-throughput

0.479

High

548636

VDAC1
Voltage-dependent anion-selective channel protein 1

1

5

High-throughput

0.479

High

548638

NDKB
Nucleoside diphosphate kinase B

1

3

High-throughput

0.479

High

548640

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

5

High-throughput

0.479

High

548641

COF1
Cofilin-1

1

6

High-throughput

0.479

High

548646

ABCD3
ATP-binding cassette sub-family D member 3

1

4

High-throughput

0.479

High

548647

TMOD1
Tropomodulin-1

1

11

High-throughput

0.479

High

548660

ATPO
ATP synthase subunit O, mitochondrial

1

2

High-throughput

0.479

High

548674

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

16

Small-scale

0.479

High

548698

PRDX4
Peroxiredoxin-4

1

4

High-throughput

0.479

High

548705

FLOT2
Flotillin-2

1

11

High-throughput

0.479

High

548710

PLEC
Plectin

1

20

High-throughput

0.479

High

548719

RIF1
Telomere-associated protein RIF1

1

16

High-throughput

0.479

High

548720

ECM29
Proteasome adapter and scaffold protein ECM29

1

9

High-throughput

0.479

High

548726

BL1S2
Biogenesis of lysosome-related organelles complex 1 subunit 2

1

2

High-throughput

0.479

High

548733

NUP93
Nuclear pore complex protein Nup93

1

2

High-throughput

0.479

High

548744

NEB2
Neurabin-2

1

20

High-throughput

0.479

High

548745

CHP1
Calcineurin B homologous protein 1

1

2

High-throughput

0.479

High

548752

SP110
Sp110 nuclear body protein

1

4

High-throughput

0.479

High

548755

LIN7C
Protein lin-7 homolog C

1

12

High-throughput

0.479

High

548764

RUVB1
RuvB-like 1

1

4

High-throughput

0.479

High

548765

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

2

High-throughput

0.479

High

548769

SRPRB
Signal recognition particle receptor subunit beta

1

5

High-throughput

0.479

High

548631

SPI1
Transcription factor PU.1

1

2

Small-scale

0.470

High

548663

EMD
Emerin

1

0

Small-scale

0.460

High

548684

FCERB
High affinity immunoglobulin epsilon receptor subunit beta

1

0

Small-scale

0.458

High

548708

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

Small-scale

0.458

High

548709

SUZ12
Polycomb protein SUZ12

1

0

Small-scale

0.458

High

548763

RTRAF
RNA transcription, translation and transport factor protein

1

0

High-throughput

0.458

High

401359

JUN
Transcription factor Jun

1

1

Small-scale

0.457

High

531706

PDIA4
Protein disulfide-isomerase A4

1

7

High-throughput

0.437

High

548652

ATPG
ATP synthase subunit gamma, mitochondrial

1

3

High-throughput

0.437

High

548664

SERPH
Serpin H1

1

7

High-throughput

0.437

High

548697

TADBP
TAR DNA-binding protein 43

1

14

High-throughput

0.437

High

548724

RL22L
Ribosomal protein eL22-like

1

4

High-throughput

0.437

High

548748

SF3B5
Splicing factor 3B subunit 5

1

2

High-throughput

0.437

High

548753

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.437

High

548757

TECR
Very-long-chain enoyl-CoA reductase

1

1

High-throughput

0.437

High

548758

TMOD2
Tropomodulin-2

1

12

High-throughput

0.437

High

548759

HACD3
Very-long-chain

1

1

High-throughput

0.437

High

548736

HAVR2
Hepatitis A virus cellular receptor 2

1

0

Small-scale

0.426

High

548728

SBSN
Suprabasin

2

0

High-throughput

0.328

High

548666

RM12
Large ribosomal subunit protein bL12m

2

0

High-throughput

0.298

High

548668

ATPK
ATP synthase subunit f, mitochondrial

2

0

High-throughput

0.298

High

548669

TMM33
Transmembrane protein 33

2

0

High-throughput

0.298

High

548717

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

2

0

High-throughput

0.298

High

548741

ATPMK
ATP synthase membrane subunit K, mitochondrial

2

0

High-throughput

0.298

High

548747

RT63
Large ribosomal subunit protein mL63

2

0

High-throughput

0.298

High

548714

CYTM
Cystatin-M

1

0

High-throughput

0.279

Low

548743

CC115
Coiled-coil domain-containing protein 115

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024