HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: GPM6A (P51674)
Neuronal membrane glycoprotein M6-a (M6a)
Gene: GPM6A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.643

Property	Details
Experiments	33961781, 26402096, 35063084
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007416 - synapse assembly GO:0031175 - neuron projection development GO:0043005 - neuron projection GO:0043025 - neuronal cell body and 1 others more... GO:0043197 - dendritic spine
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 278
+	Mm
		497937 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		GPM6A_MOUSE (1-278): 2.96e-149: 420: 98.92
+	Hs
		496971 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GPM6B_HUMAN (2-247): 8.74e-112: 325: 50.98
+	Hs
		496678 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MYPR_HUMAN (13-251): 9.93e-101: 297: 37.86
+	Rn
		581960 TAU_RAT (1-758): 4.86e-75: 260: 71.47		MYPR_RAT (13-251): 9.93e-101: 297: 37.86
+	Rn
		94183 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		MYPR_RAT (13-251): 9.93e-101: 297: 37.86
+	Hs
		503275 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		GPM6A_HUMAN (1-278): 1.69e-149: 420: 100.00
+	Hs
		203215 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		GPM6A_HUMAN (1-278): 1.69e-149: 420: 100.00
+	Hs
		554289 MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84		MYPR_HUMAN (13-251): 9.93e-101: 297: 37.86