HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: AP2S1 (P53680)
AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)
Gene: AP2S1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 142
+	Hs
		497365 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AP3S1_HUMAN (1-142): 5.3e-51: 162: 40.54
+	Hs
		496667 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AP1S2_HUMAN (2-142): 5.11e-51: 161: 46.10
+	Hs
		497548 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AP1M1_HUMAN (2-137): 4.68e-44: 150: 14.71
+	Hs
		496722 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		COPZ1_HUMAN (2-138): 3.65e-44: 144: 22.30
+	Hs
		497422 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22
+	Mm
		498140 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		AP3S1_MOUSE (1-142): 5.3e-51: 162: 40.54
+	Rn
		581982 TAU_RAT (1-758): 4.86e-75: 260: 71.47		AP2M1_RAT (1-138): 1.82e-41: 144: 15.22
+	Rn
		94205 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		AP2M1_RAT (1-138): 1.82e-41: 144: 15.22
+	Mm
		498008 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		AP2M1_MOUSE (1-138): 1.82e-41: 144: 15.22
+	Hs
		654028 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22
+	Mm
		592762 MTAP2_MOUSE (26-758): 1.71e-30: 131: 23.89		AP2S1_MOUSE (1-142): 6.18e-46: 147: 100.00
+	Mm
		649203 MAP4_MOUSE (10-742): 3.04e-29: 127: 18.63		AP2S1_MOUSE (1-142): 6.18e-46: 147: 100.00
+	Dm
		248311 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		O62530_DROME (1-138): 2.63e-42: 146: 16.67
+	Hs
		203244 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22