HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	35063084, 26269332
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0044297 - cell body
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 377
+	Hs
		496683 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ACTB_HUMAN (4-377): 0: 599: 94.12
+	Hs
		496806 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ACTG_HUMAN (4-377): 0: 599: 94.39
+	Hs
		496816 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ACTS_HUMAN (1-377): 0: 599: 98.94
+	Hs
		496759 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ACTA_HUMAN (1-377): 0: 596: 98.41
+	Mm
		498001 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		ACTC_MOUSE (1-377): 0: 599: 100.00
+	Hs
		503276 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		ACTB_HUMAN (4-377): 0: 599: 94.12
+	Hs
		932156 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		ACTC_HUMAN (1-377): 0: 599: 100.00
+	Ce
		501479 Q95QG4_CAEEL (411-693): 9.33e-25: 110: 29.33		ACT4_CAEEL (1-377): 0: 601: 94.43
+	Hs
		554290 MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84		ACTA_HUMAN (1-377): 0: 596: 98.41
+	Ce
		109402 H2KY94_CAEEL (465-688): 3.39e-25: 107: 33.48		ACT4_CAEEL (1-377): 0: 601: 94.43
+	Ce
		137705 O02592_CAEEL (353-709): 5.66e-13: 73.8: 21.29		ACT4_CAEEL (1-377): 0: 601: 94.43
+	Hs
		891853 SRCAP_HUMAN (2-474): 1.09e-12: 74.3: 9.83		ACTB_HUMAN (4-377): 0: 599: 94.12
+	Hs
		929905 SRCAP_HUMAN (2-474): 1.09e-12: 74.3: 9.83		ACTG_HUMAN (4-377): 0: 599: 94.39
+	Hs
		932219 SRCAP_HUMAN (2-474): 1.09e-12: 74.3: 9.83		ACTC_HUMAN (1-377): 0: 599: 100.00
+	Dm
		501445 CPN_DROME (345-756): 7.29e-11: 67.8: 11.17		ACT5_DROME (1-377): 0: 598: 93.10
+	Hs
		203220 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		ACTC_HUMAN (1-377): 0: 599: 100.00