Protein: SLYD
FKBP-type peptidyl-prolyl cis-trans isomerase SlyD (PPIase) (EC 5.2.1.8) (Histidine-rich protein) (Metallochaperone SlyD) (Rotamase) (Sensitivity to lysis protein D) (WHP)

Gene: SLYD
Organism: Escherichia coli K-12
Interactions: 135
UniProt ID: P0A9K9

Gene Ontology (top 5):
GO:0003755 - peptidyl-prolyl cis-trans isomerase activity
GO:0005507 - copper ion binding
GO:0005829 - cytosol
GO:0008270 - zinc ion binding
GO:0009408 - response to heat

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

494915

TIG
Trigger factor

1

0

High-throughput

0.656

High

496777

FKBX
FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.656

High

496752

HYPB
Hydrogenase maturation factor HypB

4

0

Small-scale

0.649

High

496761

DBHB
DNA-binding protein HU-beta

2

2

High-throughput

0.612

High

496798

HYCE
Formate hydrogenlyase subunit 5

2

0

Small-scale

0.592

High

496760

DBHA
DNA-binding protein HU-alpha

2

2

High-throughput

0.588

High

395108

DPO3E
DNA polymerase III subunit epsilon

2

0

High-throughput

0.585

High

496782

SSPB
Stringent starvation protein B

2

0

High-throughput

0.585

High

496820

END8
Endonuclease 8

2

0

High-throughput

0.563

High

496828

GRCA
Autonomous glycyl radical cofactor

2

0

High-throughput

0.563

High

395173

LACI
Lactose operon repressor

1

1

High-throughput

0.536

High

444340

ERA
GTPase Era

1

1

High-throughput

0.536

High

494250

RS5
Small ribosomal subunit protein uS5

1

1

High-throughput

0.536

High

494415

RS9
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

496772

RL14
Large ribosomal subunit protein uL14

1

1

High-throughput

0.536

High

496784

RL17
Large ribosomal subunit protein bL17

1

1

High-throughput

0.536

High

496790

THIO2
Thioredoxin 2

1

1

High-throughput

0.536

High

432121

APAH
Bis(5'-nucleosyl)-tetraphosphatase [symmetrical]

1

0

High-throughput

0.517

High

416315

SYE
Glutamate--tRNA ligase

1

0

High-throughput

0.513

High

490249

CLPP
ATP-dependent Clp protease proteolytic subunit

1

0

High-throughput

0.513

High

491406

HYPA
Hydrogenase maturation factor HypA

1

0

Small-scale

0.513

High

495162

YEBC
Probable transcriptional regulatory protein YebC

1

0

High-throughput

0.513

High

496758

GLRX4
Glutaredoxin 4

1

0

High-throughput

0.513

High

496762

STPA
DNA-binding protein StpA

1

0

High-throughput

0.513

High

496766

YMJA
Uncharacterized protein YmjA

1

0

High-throughput

0.513

High

496769

EDD
Phosphogluconate dehydratase

1

0

High-throughput

0.513

High

496770

ILVN
Acetolactate synthase isozyme 1 small subunit

1

0

High-throughput

0.513

High

496771

SUHB
Nus factor SuhB

1

0

High-throughput

0.513

High

496778

NUSG
Transcription termination/antitermination protein NusG

1

0

High-throughput

0.513

High

496781

RFAH
Transcription antitermination protein RfaH

1

0

High-throughput

0.513

High

496785

RL6
Large ribosomal subunit protein uL6

1

0

High-throughput

0.513

High

496787

SODF
Superoxide dismutase [Fe]

1

0

High-throughput

0.513

High

496791

ISCR
HTH-type transcriptional regulator IscR

1

0

High-throughput

0.513

High

496794

FDHE
Protein FdhE

1

0

High-throughput

0.513

High

496801

MINC
Septum site-determining protein MinC

1

0

High-throughput

0.513

High

496803

SYD
Aspartate--tRNA ligase

1

0

High-throughput

0.513

High

496806

PANB
3-methyl-2-oxobutanoate hydroxymethyltransferase

1

0

High-throughput

0.513

High

496807

FLIH
Flagellar assembly protein FliH

1

0

High-throughput

0.513

High

496809

PANC
Pantothenate synthetase

1

0

High-throughput

0.513

High

496816

OBG
GTPase ObgE/CgtA

1

0

High-throughput

0.513

High

496823

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

496825

RL5
Large ribosomal subunit protein uL5

1

0

High-throughput

0.513

High

496844

NEMA
N-ethylmaleimide reductase

1

0

High-throughput

0.513

High

496846

YAJO
1-deoxyxylulose-5-phosphate synthase YajO

1

0

High-throughput

0.513

High

496849

YQHD
NADPH-dependent aldehyde reductase YqhD

1

0

High-throughput

0.513

High

384011

RL15
Large ribosomal subunit protein uL15

1

1

High-throughput

0.489

High

420125

FLIC
Flagellin

1

1

High-throughput

0.489

High

496747

FTSE
Cell division ATP-binding protein FtsE

1

2

High-throughput

0.489

High

496786

RS1
Small ribosomal subunit protein bS1

1

1

High-throughput

0.489

High

496792

RSME
Ribosomal RNA small subunit methyltransferase E

1

1

High-throughput

0.489

High

496795

GLPD
Aerobic glycerol-3-phosphate dehydrogenase

1

1

High-throughput

0.489

High

496813

ALSB
D-allose-binding periplasmic protein

1

1

High-throughput

0.489

High

496819

YHDZ
Uncharacterized amino-acid ABC transporter ATP-binding protein YhdZ

1

1

High-throughput

0.489

High

496833

YCGX
Uncharacterized protein YcgX

1

1

High-throughput

0.489

High

496755

FTSA
Cell division protein FtsA

1

3

High-throughput

0.484

High

496804

MAK
Fructokinase

1

0

High-throughput

0.479

High

496826

YQJI
Transcriptional regulator YqjI

1

0

High-throughput

0.479

High

496776

RIMO
Ribosomal protein uS12 methylthiotransferase RimO

1

1

High-throughput

0.479

High

365868

DPO1
DNA polymerase I

1

0

High-throughput

0.464

High

490133

CH10
Co-chaperonin GroES

1

0

High-throughput

0.464

High

492065

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.464

High

492226

PYRH
Uridylate kinase

1

0

High-throughput

0.464

High

495497

SYS
Serine--tRNA ligase

1

0

High-throughput

0.464

High

496779

PARC
DNA topoisomerase 4 subunit A

1

0

High-throughput

0.464

High

496812

BCSQP
Putative cellulose biosynthesis protein BcsQ

1

0

High-throughput

0.464

High

496814

ULAF
L-ribulose-5-phosphate 4-epimerase UlaF

1

0

High-throughput

0.464

High

496748

YRDA
Protein YrdA

1

0

High-throughput

0.458

High

496757

KDSC
3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC

1

0

High-throughput

0.458

High

496759

LGUL
Lactoylglutathione lyase

1

0

High-throughput

0.458

High

496767

LETA
Lipophilic envelope-spanning tunnel protein A

1

0

High-throughput

0.458

High

496780

GCH1L
GTP cyclohydrolase 1 type 2 homolog

1

0

High-throughput

0.458

High

496837

KDGR
HTH-type transcriptional regulator KdgR

1

0

High-throughput

0.458

High

496841

5DNU
5'-deoxynucleotidase YfbR

1

0

High-throughput

0.458

High

496847

MENI
1,4-dihydroxy-2-naphthoyl-CoA hydrolase

1

0

High-throughput

0.458

High

496749

THIO
Thioredoxin 1

1

1

Small-scale

0.445

High

496750

GLTL
Glutamate/aspartate import ATP-binding protein GltL

1

2

High-throughput

0.442

High

496751

SAPD
Putrescine export system ATP-binding protein SapD

1

3

High-throughput

0.442

High

496387

GLPC
Anaerobic glycerol-3-phosphate dehydrogenase subunit C

1

1

High-throughput

0.437

High

496840

PRET
NAD-dependent dihydropyrimidine dehydrogenase subunit PreT

1

1

High-throughput

0.437

High

494052

RS4
Small ribosomal subunit protein uS4

1

0

High-throughput

0.426

High

496788

SSB
Single-stranded DNA-binding protein

1

0

High-throughput

0.426

High

496775

DSBC
Thiol:disulfide interchange protein DsbC

2

0

High-throughput

0.318

High

495264

YACL
UPF0231 protein YacL

2

0

High-throughput

0.307

High

496756

DPS
DNA protection during starvation protein

2

0

High-throughput

0.307

High

496829

MBHS
Hydrogenase-1 small chain

2

0

High-throughput

0.305

High

408524

3MG2
DNA-3-methyladenine glycosylase 2

1

0

High-throughput

0.279

Low

445441

MUTH
DNA mismatch repair protein MutH

1

0

High-throughput

0.279

Low

469363

YCIH
Uncharacterized protein YciH

1

0

High-throughput

0.279

Low

490382

CYSC
Adenylyl-sulfate kinase

1

0

High-throughput

0.279

Low

491927

RPPH
RNA pyrophosphohydrolase

1

0

High-throughput

0.279

Low

492863

RL27
Large ribosomal subunit protein bL27

1

0

High-throughput

0.279

Low

494758

SFSA
Sugar fermentation stimulation protein A

1

0

High-throughput

0.279

Low

496003

YCEI
Protein YceI

1

0

High-throughput

0.279

Low

496084

MIPA
MltA-interacting protein

1

0

High-throughput

0.279

Low

496610

MUG
G/U mismatch-specific DNA glycosylase

1

0

High-throughput

0.279

Low

496753

YCGL
Protein YcgL

1

0

High-throughput

0.279

Low

496754

END3
Endonuclease III

1

0

High-throughput

0.279

Low

496763

FUCR
L-fucose operon activator

1

0

High-throughput

0.279

Low

496764

RPIR
HTH-type transcriptional regulator RpiR

1

0

High-throughput

0.279

Low

496765

RUTR
HTH-type transcriptional regulator RutR

1

0

High-throughput

0.279

Low

496773

RL23
Large ribosomal subunit protein uL23

1

0

High-throughput

0.279

Low

496774

CORC
Magnesium and cobalt efflux protein CorC

1

0

High-throughput

0.279

Low

496783

RELA
GTP pyrophosphokinase

1

0

High-throughput

0.279

Low

496789

THIL
Thiamine-monophosphate kinase

1

0

High-throughput

0.279

Low

496793

HCAB
3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase

1

0

High-throughput

0.279

Low

496797

RACC
Protein RacC

1

0

High-throughput

0.279

Low

496800

BETA
Oxygen-dependent choline dehydrogenase

1

0

High-throughput

0.279

Low

496802

INSA7
Insertion element IS1 7 protein InsA

1

0

High-throughput

0.279

Low

496810

NRFG
Formate-dependent nitrite reductase complex subunit NrfG

1

0

High-throughput

0.279

Low

496811

YCHJ
UPF0225 protein YchJ

1

0

High-throughput

0.279

Low

496815

YHAK
Pirin-like protein YhaK

1

0

High-throughput

0.279

Low

496818

YHBQ
UPF0213 protein YhbQ

1

0

High-throughput

0.279

Low

496821

RATB
UPF0125 protein RatB

1

0

High-throughput

0.279

Low

496822

CAIA
Crotonobetainyl-CoA reductase

1

0

High-throughput

0.279

Low

496827

YHAJ
Probable HTH-type transcriptional regulator YhaJ

1

0

High-throughput

0.279

Low

496830

WCAK
Colanic acid biosynthesis protein WcaK

1

0

High-throughput

0.279

Low

496831

YAGP
Putative LysR family substrate binding domain-containing protein YagP

1

0

High-throughput

0.279

Low

496832

THIK
Thiamine kinase

1

0

High-throughput

0.279

Low

496834

BLUR
HTH-type transcriptional repressor BluR

1

0

High-throughput

0.279

Low

496835

YCGM
Oxaloacetate tautomerase YcgM

1

0

High-throughput

0.279

Low

496836

YNCG
Uncharacterized GST-like protein YncG

1

0

High-throughput

0.279

Low

496838

YEDK
Abasic site processing protein YedK

1

0

High-throughput

0.279

Low

496839

YEGV
Uncharacterized sugar kinase YegV

1

0

High-throughput

0.279

Low

496842

MURQ
N-acetylmuramic acid 6-phosphate etherase

1

0

High-throughput

0.279

Low

496843

EUTQ
Acetate kinase EutQ

1

0

High-throughput

0.279

Low

496845

YAGL
Uncharacterized protein YagL

1

0

High-throughput

0.279

Low

496848

XDHB
Putative xanthine dehydrogenase FAD-binding subunit XdhB

1

0

High-throughput

0.279

Low

496850

LTND
L-threonate dehydrogenase

1

0

High-throughput

0.279

Low

496796

MURD
UDP-N-acetylmuramoylalanine--D-glutamate ligase

1

0

High-throughput

0.269

Low

496799

PHNP
Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase

1

0

High-throughput

0.269

Low

496808

YDEI
Uncharacterized protein YdeI

1

0

High-throughput

0.253

Low

496817

NUDL
Uncharacterized Nudix hydrolase NudL

1

0

High-throughput

0.253

Low

496768

AMPH
D-alanyl-D-alanine-carboxypeptidase/endopeptidase AmpH

1

0

High-throughput

0.249

Low

496824

LOLB
Outer-membrane lipoprotein LolB

1

0

High-throughput

0.249

Low

496805

INSZ
Putative transposase InsZ

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025