HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: HNRPD (Q14103)
Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1)
Gene: HNRNPD

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.657

Property	Details
Experiments	26269332, 30021884, 35063084
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003680 - minor groove of adenine-thymine-rich DNA binding GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0010629 - negative regulation of gene expression
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 355
+	Hs
		161944 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HNRDL_HUMAN (89-355): 3.71e-56: 190: 62.63
+	Hs
		497496 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ROAA_HUMAN (30-355): 3.41e-55: 185: 53.89
+	Hs
		496607 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ROA3_HUMAN (64-265): 2.66e-50: 174: 37.02
+	Hs
		496957 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PABP4_HUMAN (88-272): 4.65e-43: 159: 18.52
+	Hs
		496179 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PABP1_HUMAN (88-272): 2.1e-42: 157: 16.93
+	Hs
		496306 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ROA2_HUMAN (98-277): 8.38e-39: 142: 41.40
+	Rn
		582022 TAU_RAT (1-758): 4.86e-75: 260: 71.47		ROA3_RAT (64-265): 2.72e-50: 174: 37.02
+	Rn
		94248 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		ROA3_RAT (64-265): 2.72e-50: 174: 37.02
+	Rn
		582032 TAU_RAT (1-758): 4.86e-75: 260: 71.47		PABP1_RAT (88-272): 2.23e-42: 157: 16.93
+	Rn
		94258 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		PABP1_RAT (88-272): 2.23e-42: 157: 16.93
+	Rn
		64991 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		ROA2_RAT (98-277): 1.05e-38: 142: 41.40
+	Rn
		64993 TAU_RAT (1-758): 4.86e-75: 260: 71.47		ROA2_RAT (98-277): 1.05e-38: 142: 41.40
+	Mm
		498054 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		Q62029_MOUSE (88-270): 7.05e-40: 150: 17.65
+	Hs
		453100 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ROA1_HUMAN (63-177): 4.79e-20: 92: 26.83
+	Hs
		201653 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MSI1H_HUMAN (21-180): 2.38e-16: 81: 28.13
+	Hs
		497424 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MSI2H_HUMAN (21-198): 1.49e-15: 78.3: 26.82
+	Hs
		496405 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TIA1_HUMAN (176-270): 9.56e-14: 73.6: 18.75
+	Hs
		654044 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		ROAA_HUMAN (30-355): 3.41e-55: 185: 53.89
+	Mm
		497953 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		TIA1_MOUSE (176-270): 8.88e-14: 73.6: 18.75
+	Hs
		1056955 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		ROAA_HUMAN (30-355): 3.41e-55: 185: 53.89